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Items: 18


Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress.

Jing FC, Zhang J, Feng C, Nian YY, Wang JH, Hu H, Yang BD, Sun XM, Zheng JY, Yin XR.

World J Gastroenterol. 2017 Nov 14;23(42):7594-7608. doi: 10.3748/wjg.v23.i42.7594.


The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats.

Li X, Kaczanowska K, Finn MG, Markou A, Risbrough VB.

Neuropharmacology. 2015 Oct;97:357-64. doi: 10.1016/j.neuropharm.2015.05.001. Epub 2015 May 19.


Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile.

Kalinichev M, Donovan-Rodriguez T, Girard F, Riguet E, Rouillier M, Bournique B, Haddouk H, Mutel V, Poli S.

Br J Pharmacol. 2014 Nov;171(21):4941-54. doi: 10.1111/bph.12812. Epub 2014 Sep 5.


Positive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models.

Frau R, Bini V, Pillolla G, Malherbe P, Pardu A, Thomas AW, Devoto P, Bortolato M.

CNS Neurosci Ther. 2014 Jul;20(7):679-84. doi: 10.1111/cns.12261. Epub 2014 Apr 7.


ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.

Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M, Poli S.

Br J Pharmacol. 2014 Feb;171(4):995-1006. doi: 10.1111/bph.12517.


Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice.

Hwa LS, Kalinichev M, Haddouk H, Poli S, Miczek KA.

Psychopharmacology (Berl). 2014 Jan;231(2):333-43. doi: 10.1007/s00213-013-3245-z. Epub 2013 Aug 22.


The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.

Hoestgaard-Jensen K, O'Connor RM, Dalby NO, Simonsen C, Finger BC, Golubeva A, Hammer H, Bergmann ML, Kristiansen U, Krogsgaard-Larsen P, Bräuner-Osborne H, Ebert B, Frølund B, Cryan JF, Jensen AA.

Br J Pharmacol. 2013 Oct;170(4):919-32. doi: 10.1111/bph.12340.


Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation.

Li X, Semenova S, D'Souza MS, Stoker AK, Markou A.

Neuropharmacology. 2014 Jan;76 Pt B:554-65. doi: 10.1016/j.neuropharm.2013.05.042. Epub 2013 Jun 7. Review.


Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice.

Li X, Risbrough VB, Cates-Gatto C, Kaczanowska K, Finn MG, Roberts AJ, Markou A.

Neuropharmacology. 2013 Jul;70:156-67. doi: 10.1016/j.neuropharm.2013.01.018. Epub 2013 Jan 29.


Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.

Koek W, Cheng K, Rice KC.

J Pharmacol Exp Ther. 2013 Mar;344(3):553-60. doi: 10.1124/jpet.112.202226. Epub 2012 Dec 28.


Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission.

Rey AA, Purrio M, Viveros MP, Lutz B.

Neuropsychopharmacology. 2012 Nov;37(12):2624-34. doi: 10.1038/npp.2012.123. Epub 2012 Aug 1.


Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons.

Koek W, France CP, Cheng K, Rice KC.

J Pharmacol Exp Ther. 2012 May;341(2):369-76. doi: 10.1124/jpet.111.190975. Epub 2012 Feb 7.


Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.

Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, Conn PJ, Lindsley CW.

J Med Chem. 2012 Feb 23;55(4):1445-64. doi: 10.1021/jm201139r. Epub 2012 Jan 6. No abstract available.


The GABA B receptor agonist CGP44532 and the positive modulator GS39783 reverse some behavioural changes related to positive syndromes of psychosis in mice.

Wierońska JM, Kusek M, Tokarski K, Wabno J, Froestl W, Pilc A.

Br J Pharmacol. 2011 Jul;163(5):1034-47. doi: 10.1111/j.1476-5381.2011.01301.x.


Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents.

Braun AA, Skelton MR, Vorhees CV, Williams MT.

Pharmacol Biochem Behav. 2011 Jan;97(3):406-15. doi: 10.1016/j.pbb.2010.09.013. Epub 2010 Sep 24.


The GABAβ receptor as a target for antidepressant drug action.

Ghose S, Winter MK, McCarson KE, Tamminga CA, Enna SJ.

Br J Pharmacol. 2011 Jan;162(1):1-17. doi: 10.1111/j.1476-5381.2010.01004.x. Review.


GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.

Koek W, France CP, Cheng K, Rice KC.

J Pharmacol Exp Ther. 2010 Oct;335(1):163-71. doi: 10.1124/jpet.110.171116. Epub 2010 Jul 13.


Type B GABA receptors contribute to the restoration of balance during vestibular compensation in mice.

Heskin-Sweezie R, Titley HK, Baizer JS, Broussard DM.

Neuroscience. 2010 Aug 11;169(1):302-14. doi: 10.1016/j.neuroscience.2010.04.008. Epub 2010 Apr 13.

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