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Items: 17


ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels.

Ioannou MS, Fahnestock M.

Int J Mol Sci. 2017 Mar 9;18(3). pii: E599. doi: 10.3390/ijms18030599.


The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.

Bucci C, Alifano P, Cogli L.

Membranes (Basel). 2014 Oct 6;4(4):642-77. doi: 10.3390/membranes4040642. Review.


The neuroprotective roles of BDNF in hypoxic ischemic brain injury.

Chen A, Xiong LJ, Tong Y, Mao M.

Biomed Rep. 2013 Mar;1(2):167-176. Epub 2012 Dec 14. Review.


Pro-neurotrophins, sortilin, and nociception.

Lewin GR, Nykjaer A.

Eur J Neurosci. 2014 Feb;39(3):363-74. doi: 10.1111/ejn.12466. Review.


ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism.

Howard L, Wyatt S, Nagappan G, Davies AM.

Development. 2013 May;140(10):2108-17. doi: 10.1242/dev.085266.


A single Aplysia neurotrophin mediates synaptic facilitation via differentially processed isoforms.

Kassabov SR, Choi YB, Karl KA, Vishwasrao HD, Bailey CH, Kandel ER.

Cell Rep. 2013 Apr 25;3(4):1213-27. doi: 10.1016/j.celrep.2013.03.008. Epub 2013 Apr 4.


Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration.

Matragoon S, Al-Gayyar MM, Mysona BA, Abdelsaid MA, Pillai BA, Neet KE, Fagan SC, El-Remessy AB.

Mol Vis. 2012;18:2993-3003. Epub 2012 Dec 14.


Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.

Kalous A, Nangle MR, Anastasia A, Hempstead BL, Keast JR.

J Neurochem. 2012 Aug;122(3):523-36. doi: 10.1111/j.1471-4159.2012.07799.x. Epub 2012 Jun 12.


Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein.

Demont Y, Corbet C, Page A, Ataman-├ľnal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H.

J Biol Chem. 2012 Jan 13;287(3):1923-31. doi: 10.1074/jbc.M110.211714. Epub 2011 Nov 29.


Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

Evans SF, Irmady K, Ostrow K, Kim T, Nykjaer A, Saftig P, Blobel C, Hempstead BL.

J Biol Chem. 2011 Aug 26;286(34):29556-67. doi: 10.1074/jbc.M111.219675. Epub 2011 Jul 5.


Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.

Kwon S, Christian JL.

J Biol Chem. 2011 Jun 17;286(24):21876-85. doi: 10.1074/jbc.M111.228262. Epub 2011 Apr 26.


Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis.

Li Y, Zhang SF, Zou SE, Xia X, Bao L.

Reprod Biol Endocrinol. 2011 Mar 8;9:30. doi: 10.1186/1477-7827-9-30.


Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling.

Wang T, Liu YY, Wang X, Yang N, Zhu HB, Zuo PP.

Acta Pharmacol Sin. 2010 Jul;31(7):765-74. doi: 10.1038/aps.2010.69. Epub 2010 Jun 28.


Understanding proneurotrophin actions: Recent advances and challenges.

Teng KK, Felice S, Kim T, Hempstead BL.

Dev Neurobiol. 2010 Apr;70(5):350-9. doi: 10.1002/dneu.20768. Review.


Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing.

Yano H, Torkin R, Martin LA, Chao MV, Teng KK.

J Neurosci. 2009 Nov 25;29(47):14790-802. doi: 10.1523/JNEUROSCI.2059-09.2009.


Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors.

Masoudi R, Ioannou MS, Coughlin MD, Pagadala P, Neet KE, Clewes O, Allen SJ, Dawbarn D, Fahnestock M.

J Biol Chem. 2009 Jul 3;284(27):18424-33. doi: 10.1074/jbc.M109.007104. Epub 2009 Apr 23.

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