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HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases.

Kung PH, Hsieh PW, Lin YT, Lee JH, Chen IH, Wu CC.

Redox Biol. 2017 Oct;13:266-277. doi: 10.1016/j.redox.2017.05.019. Epub 2017 May 29.


The disulfide isomerase ERp72 supports arterial thrombosis in mice.

Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J, Essex DW.

Blood. 2017 Aug 10;130(6):817-828. doi: 10.1182/blood-2016-12-755587. Epub 2017 Jun 2.


Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells.

Araujo TLS, Fernandes CG, Laurindo FRM.

Redox Biol. 2017 Aug;12:1004-1010. doi: 10.1016/j.redox.2017.04.034. Epub 2017 May 3.


Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W.

Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1323-1331. doi: 10.1161/ATVBAHA.117.309315. Epub 2017 May 11.


Challenges in the evaluation of thiol-reactive inhibitors of human protein disulfide Isomerase.

Foster CK, Thorpe C.

Free Radic Biol Med. 2017 Jul;108:741-749. doi: 10.1016/j.freeradbiomed.2017.04.367. Epub 2017 Apr 30.


Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates.

Stopa JD, Baker KM, Grover SP, Flaumenhaft R, Furie B.

J Biol Chem. 2017 Jun 2;292(22):9063-9074. doi: 10.1074/jbc.M116.771832. Epub 2017 Mar 31.


Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development.

Subramaniam S, Jurk K, Hobohm L, J├Ąckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W.

Blood. 2017 Apr 20;129(16):2291-2302. doi: 10.1182/blood-2016-11-749879. Epub 2017 Feb 21.


Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation.

Bowley SR, Fang C, Merrill-Skoloff G, Furie BC, Furie B.

Nat Commun. 2017 Feb 20;8:14151. doi: 10.1038/ncomms14151.


A new antithrombotic strategy: inhibition of the C-terminal active site of protein disulfide isomerase.

Wang L, Essex DW.

J Thromb Haemost. 2017 Apr;15(4):770-773. doi: 10.1111/jth.13634. Epub 2017 Feb 28. No abstract available.


Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation.

Stopa JD, Neuberg D, Puligandla M, Furie B, Flaumenhaft R, Zwicker JI.

JCI Insight. 2017 Jan 12;2(1):e89373. doi: 10.1172/jci.insight.89373.


Endothelial cells microparticle-associated protein disulfide isomerase promotes platelet activation in metabolic syndrome.

Fan GQ, Qin RR, Li YH, Song DJ, Chen TS, Zhang W, Zhong M, Zhang Y, Xing YQ, Wang ZH.

Oncotarget. 2016 Dec 13;7(50):83231-83240. doi: 10.18632/oncotarget.13081.


Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.

Metcalfe C, Ramasubramoni A, Pula G, Harper MT, Mundell SJ, Coxon CH.

PLoS One. 2016 Oct 7;11(10):e0163006. doi: 10.1371/journal.pone.0163006. eCollection 2016.


A substrate-driven allosteric switch that enhances PDI catalytic activity.

Bekendam RH, Bendapudi PK, Lin L, Nag PP, Pu J, Kennedy DR, Feldenzer A, Chiu J, Cook KM, Furie B, Huang M, Hogg PJ, Flaumenhaft R.

Nat Commun. 2016 Aug 30;7:12579. doi: 10.1038/ncomms12579.


Vascular thiol isomerases.

Flaumenhaft R, Furie B.

Blood. 2016 Aug 18;128(7):893-901. doi: 10.1182/blood-2016-04-636456. Epub 2016 Jun 29. Review.


Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation.

Kim JE, Yoo HJ, Gu JY, Kim HK.

PLoS One. 2016 Jun 3;11(6):e0156763. doi: 10.1371/journal.pone.0156763. eCollection 2016.


Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1164-73. doi: 10.1161/ATVBAHA.116.307461. Epub 2016 Apr 14.


Targeting clotting proteins in cancer therapy - progress and challenges.

Ruf W, Rothmeier AS, Graf C.

Thromb Res. 2016 Apr;140 Suppl 1:S1-7. doi: 10.1016/S0049-3848(16)30090-1. Review.


Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment.

Yi MC, Khosla C.

Annu Rev Chem Biomol Eng. 2016 Jun 7;7:197-222. doi: 10.1146/annurev-chembioeng-080615-033553. Epub 2016 Mar 17. Review.


OX133, a monoclonal antibody recognizing protein-bound N-ethylmaleimide for the identification of reduced disulfide bonds in proteins.

Holbrook LM, Kwong LS, Metcalfe CL, Fenouillet E, Jones IM, Barclay AN.

MAbs. 2016 May-Jun;8(4):672-7. doi: 10.1080/19420862.2016.1152443. Epub 2016 Mar 17.

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