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Items: 19


Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

Vong K, Auclair K.

Medchemcomm. 2012 Apr 1;3(4):397-407. doi: 10.1039/C2MD00253A.


Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT).

Salah Ud-Din AI, Tikhomirova A, Roujeinikova A.

Int J Mol Sci. 2016 Jun 28;17(7). pii: E1018. doi: 10.3390/ijms17071018. Review.


Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking.

Chiem K, Jani S, Fuentes B, Lin DL, Rasche ME, Tolmasky ME.

Medchemcomm. 2016 Jan 1;7(1):184-189.


Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.

Favrot L, Blanchard JS, Vergnolle O.

Biochemistry. 2016 Feb 23;55(7):989-1002. doi: 10.1021/acs.biochem.5b01269. Review.


Mechanisms of drug resistance: quinolone resistance.

Hooper DC, Jacoby GA.

Ann N Y Acad Sci. 2015 Sep;1354:12-31. doi: 10.1111/nyas.12830. Review.


Plasmid-mediated quinolone resistance.

Jacoby GA, Strahilevitz J, Hooper DC.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.PLAS-0006-2013. Review.


Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.

Smith CA, Toth M, Weiss TM, Frase H, Vakulenko SB.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2754-64. doi: 10.1107/S1399004714017635.


Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments.

Majorek KA, Kuhn ML, Chruszcz M, Anderson WF, Minor W.

Protein Sci. 2014 Oct;23(10):1359-68. doi: 10.1002/pro.2520.


Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.

Ramirez MS, Nikolaidis N, Tolmasky ME.

Front Microbiol. 2013 May 17;4:121. doi: 10.3389/fmicb.2013.00121.


Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens.

Green KD, Garneau-Tsodikova S.

Biochimie. 2013 Jun;95(6):1319-25. doi: 10.1016/j.biochi.2013.02.011.


Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.

Chen W, Biswas T, Porter VR, Tsodikov OV, Garneau-Tsodikova S.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9804-8. doi: 10.1073/pnas.1105379108.


Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.

Green KD, Chen W, Garneau-Tsodikova S.

Antimicrob Agents Chemother. 2011 Jul;55(7):3207-13. doi: 10.1128/AAC.00312-11.


Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor.

Hegde SS, Vetting MW, Mitchenall LA, Maxwell A, Blanchard JS.

Antimicrob Agents Chemother. 2011 Jan;55(1):110-7. doi: 10.1128/AAC.01158-10.


Aminoglycoside modifying enzymes.

Ramirez MS, Tolmasky ME.

Drug Resist Updat. 2010 Dec;13(6):151-71. doi: 10.1016/j.drup.2010.08.003. Review.


Plasmid-mediated quinolone resistance: a multifaceted threat.

Strahilevitz J, Jacoby GA, Hooper DC, Robicsek A.

Clin Microbiol Rev. 2009 Oct;22(4):664-89. doi: 10.1128/CMR.00016-09. Review.


Temporal appearance of plasmid-mediated quinolone resistance genes.

Jacoby GA, Gacharna N, Black TA, Miller GH, Hooper DC.

Antimicrob Agents Chemother. 2009 Apr;53(4):1665-6. doi: 10.1128/AAC.01447-08.


Synonymous genes explore different evolutionary landscapes.

Cambray G, Mazel D.

PLoS Genet. 2008 Nov;4(11):e1000256. doi: 10.1371/journal.pgen.1000256.


Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant.

Vetting MW, Park CH, Hegde SS, Jacoby GA, Hooper DC, Blanchard JS.

Biochemistry. 2008 Sep 16;47(37):9825-35. doi: 10.1021/bi800664x.

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