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Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus.

Gao P, Davies J, Kao RYT.

MBio. 2017 Sep 5;8(5). pii: e01224-17. doi: 10.1128/mBio.01224-17.


Structural and Chemical Biology of Terpenoid Cyclases.

Christianson DW.

Chem Rev. 2017 Sep 13;117(17):11570-11648. doi: 10.1021/acs.chemrev.7b00287. Epub 2017 Aug 25. Review.


Myricetin protects Galleria mellonella against Staphylococcus aureus infection and inhibits multiple virulence factors.

Silva LN, Da Hora GCA, Soares TA, Bojer MS, Ingmer H, Macedo AJ, Trentin DS.

Sci Rep. 2017 Jun 6;7(1):2823. doi: 10.1038/s41598-017-02712-1.


Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis.

Rashid R, Cazenave-Gassiot A, Gao IH, Nair ZJ, Kumar JK, Gao L, Kline KA, Wenk MR.

PLoS One. 2017 Apr 19;12(4):e0175886. doi: 10.1371/journal.pone.0175886. eCollection 2017.


Head-to-Head Prenyl Synthases in Pathogenic Bacteria.

Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E.

Chembiochem. 2017 Jun 1;18(11):985-991. doi: 10.1002/cbic.201700099. Epub 2017 Apr 25.


How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient.

Hansen E, Woods RJ, Read AF.

PLoS Biol. 2017 Feb 9;15(2):e2001110. doi: 10.1371/journal.pbio.2001110. eCollection 2017 Feb.


Manipulating virulence factor availability can have complex consequences for infections.

Weigert M, Ross-Gillespie A, Leinweber A, Pessi G, Brown SP, Kümmerli R.

Evol Appl. 2016 Oct 24;10(1):91-101. doi: 10.1111/eva.12431. eCollection 2017 Jan.


Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies.

Birt MC, Anderson DW, Bruce Toby E, Wang J.

J Orthop. 2016 Oct 26;14(1):45-52. eCollection 2017 Mar. Review.


Growth-Environment Dependent Modulation of Staphylococcus aureus Branched-Chain to Straight-Chain Fatty Acid Ratio and Incorporation of Unsaturated Fatty Acids.

Sen S, Sirobhushanam S, Johnson SR, Song Y, Tefft R, Gatto C, Wilkinson BJ.

PLoS One. 2016 Oct 27;11(10):e0165300. doi: 10.1371/journal.pone.0165300. eCollection 2016.


Considerations and caveats in anti-virulence drug development.

Maura D, Ballok AE, Rahme LG.

Curr Opin Microbiol. 2016 Oct;33:41-46. doi: 10.1016/j.mib.2016.06.001. Epub 2016 Jun 16. Review.


The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation.

Langdon A, Crook N, Dantas G.

Genome Med. 2016 Apr 13;8(1):39. doi: 10.1186/s13073-016-0294-z. Review.


Beyond killing: Can we find new ways to manage infection?

Vale PF, McNally L, Doeschl-Wilson A, King KC, Popat R, Domingo-Sananes MR, Allen JE, Soares MP, Kümmerli R.

Evol Med Public Health. 2016 Apr 18;2016(1):148-57. doi: 10.1093/emph/eow012. Print 2016. Review.


Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase.

Liu M, Chen CC, Chen L, Xiao X, Zheng Y, Huang JW, Liu W, Ko TP, Cheng YS, Feng X, Oldfield E, Guo RT, Ma Y.

Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4721-4. doi: 10.1002/anie.201600656. Epub 2016 Feb 29.


Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.

York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ.

Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.


Mechanisms of drug resistance: daptomycin resistance.

Tran TT, Munita JM, Arias CA.

Ann N Y Acad Sci. 2015 Sep;1354:32-53. doi: 10.1111/nyas.12948. Epub 2015 Oct 23. Review.


Raft-like membrane domains in pathogenic microorganisms.

Farnoud AM, Toledo AM, Konopka JB, Del Poeta M, London E.

Curr Top Membr. 2015;75:233-68. doi: 10.1016/bs.ctm.2015.03.005. Epub 2015 Apr 11. Review.


Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.

Liu YL, Cao R, Wang Y, Oldfield E.

ACS Med Chem Lett. 2015 Jan 29;6(3):349-54. doi: 10.1021/ml500528x. eCollection 2015 Mar 12.


Bacterial fitness shapes the population dynamics of antibiotic-resistant and -susceptible bacteria in a model of combined antibiotic and anti-virulence treatment.

Ternent L, Dyson RJ, Krachler AM, Jabbari S.

J Theor Biol. 2015 May 7;372:1-11. doi: 10.1016/j.jtbi.2015.02.011. Epub 2015 Feb 18.


Staphylococcus aureus adapts to oxidative stress by producing H2O2-resistant small-colony variants via the SOS response.

Painter KL, Strange E, Parkhill J, Bamford KB, Armstrong-James D, Edwards AM.

Infect Immun. 2015 May;83(5):1830-44. doi: 10.1128/IAI.03016-14. Epub 2015 Feb 17.

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