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Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.

Ramesh N, Pandey UB.

Front Mol Neurosci. 2017 Aug 22;10:263. doi: 10.3389/fnmol.2017.00263. eCollection 2017. Review.


Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.

Dai S, Dulcey AE, Hu X, Wassif CA, Porter FD, Austin CP, Ory DS, Marugan J, Zheng W.

Autophagy. 2017 Aug 3;13(8):1435-1451. doi: 10.1080/15548627.2017.1329081. Epub 2017 Jun 14.


Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.

Zhang Y, Cross SD, Stanton JB, Marmorstein AD, Le YZ, Marmorstein LY.

Mol Vis. 2017 Apr 14;23:228-241. eCollection 2017.


PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.

Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P.

Am J Hum Genet. 2017 May 4;100(5):706-724. doi: 10.1016/j.ajhg.2017.03.008. Epub 2017 Apr 13.


ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

Petrov D, Mansfield C, Moussy A, Hermine O.

Front Aging Neurosci. 2017 Mar 22;9:68. doi: 10.3389/fnagi.2017.00068. eCollection 2017. Review.


Outcome measures in amyotrophic lateral sclerosis clinical trials.

Paganoni S, Cudkowicz M, Berry JD.

Clin Investig (Lond). 2014;4(7):605-618.


IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.

Sade Y, Toker L, Kara NZ, Einat H, Rapoport S, Moechars D, Berry GT, Bersudsky Y, Agam G.

Transl Psychiatry. 2016 Dec 6;6(12):e968. doi: 10.1038/tp.2016.217.


Motor neuron mitochondrial dysfunction in spinal muscular atrophy.

Miller N, Shi H, Zelikovich AS, Ma YC.

Hum Mol Genet. 2016 Aug 15;25(16):3395-3406. doi: 10.1093/hmg/ddw262. Epub 2016 Aug 3.


A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts.

Dell'Osso L, Del Grande C, Gesi C, Carmassi C, Musetti L.

Neuropsychiatr Dis Treat. 2016 Jul 11;12:1687-703. doi: 10.2147/NDT.S106479. eCollection 2016. Review.


Opposite Interplay between PPAR Gamma and Canonical Wnt/Beta-Catenin Pathway in Amyotrophic Lateral Sclerosis.

Lecarpentier Y, Vallée A.

Front Neurol. 2016 Jun 28;7:100. doi: 10.3389/fneur.2016.00100. eCollection 2016. Review.


DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.

Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA.

EMBO J. 2016 Jul 15;35(14):1537-49. doi: 10.15252/embj.201593489. Epub 2016 Jun 3.


Stress granules at the intersection of autophagy and ALS.

Monahan Z, Shewmaker F, Pandey UB.

Brain Res. 2016 Oct 15;1649(Pt B):189-200. doi: 10.1016/j.brainres.2016.05.022. Epub 2016 May 13. Review.


Current Therapy of Drugs in Amyotrophic Lateral Sclerosis.

Lu H, Le WD, Xie YY, Wang XP.

Curr Neuropharmacol. 2016;14(4):314-21. Review.


Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis.

Natale G, Lenzi P, Lazzeri G, Falleni A, Biagioni F, Ryskalin L, Fornai F.

Front Cell Neurosci. 2015 Nov 6;9:434. doi: 10.3389/fncel.2015.00434. eCollection 2015.


Potential application of lithium in Parkinson's and other neurodegenerative diseases.

Lazzara CA, Kim YH.

Front Neurosci. 2015 Oct 27;9:403. doi: 10.3389/fnins.2015.00403. eCollection 2015. Review.


The altered autophagy mediated by TFEB in animal and cell models of amyotrophic lateral sclerosis.

Chen Y, Liu H, Guan Y, Wang Q, Zhou F, Jie L, Ju J, Pu L, Du H, Wang X.

Am J Transl Res. 2015 Sep 15;7(9):1574-87. eCollection 2015.


Regulation of autophagy by Beclin 1 in the heart.

Maejima Y, Isobe M, Sadoshima J.

J Mol Cell Cardiol. 2016 Jun;95:19-25. doi: 10.1016/j.yjmcc.2015.10.032. Epub 2015 Nov 9. Review.


Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats.

Boyko M, Nassar A, Kaplanski J, Zlotnik A, Sharon-Granit Y, Azab AN.

Biomed Res Int. 2015;2015:916234. doi: 10.1155/2015/916234. Epub 2015 Sep 27.


Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis.

Ruffoli R, Bartalucci A, Frati A, Fornai F.

Front Cell Neurosci. 2015 Sep 1;9:341. doi: 10.3389/fncel.2015.00341. eCollection 2015. Review.


Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.

LaPash Daniels CM, Paffenroth E, Austin EV, Glebov K, Lewis D, Walter J, Messing A.

PLoS One. 2015 Sep 17;10(9):e0138132. doi: 10.1371/journal.pone.0138132. eCollection 2015.

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