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Items: 1 to 20 of 116


Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.

He LF, Xu HW, Chen M, Xian ZR, Wen XF, Chen MN, Du CW, Huang WH, Wu JD, Zhang GJ.

Oncotarget. 2017 Mar 14;8(11):17573-17585. doi: 10.18632/oncotarget.7466.


Structure, biochemistry, and biology of PAK kinases.

Kumar R, Sanawar R, Li X, Li F.

Gene. 2017 Mar 20;605:20-31. doi: 10.1016/j.gene.2016.12.014. Epub 2016 Dec 19. Review.


Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.

Joseph GA, Lu M, Radu M, Lee JK, Burden SJ, Chernoff J, Krauss RS.

Mol Cell Biol. 2017 Feb 1;37(4). pii: e00222-16. doi: 10.1128/MCB.00222-16. Print 2017 Feb 15.


Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway.

Sun Z, Zhang B, Wang C, Fu T, Li L, Wu Q, Cai Y, Wang J.

Cancer Sci. 2017 Jan;108(1):61-72. doi: 10.1111/cas.13118. Epub 2017 Jan 23.


Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?

Thillai K, Lam H, Sarker D, Wells CM.

Oncotarget. 2017 Feb 21;8(8):14173-14191. doi: 10.18632/oncotarget.13309. Review.


PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.

Nicholas NS, Pipili A, Lesjak MS, Ameer-Beg SM, Geh JL, Healy C, MacKenzie Ross AD, Parsons M, Nestle FO, Lacy KE, Wells CM.

Oncotarget. 2016 Oct 25;7(43):70881-70897. doi: 10.18632/oncotarget.12282.


Inhibiting p21-Activated Kinase Induces Cell Death in Vestibular Schwannoma and Meningioma via Mitotic Catastrophe.

Mercado-Pimentel ME, Miller C, Rolph DN, Villalobos EF, Dunn AM, Mohan PM, Igarashi S, Liu X, Yrun-Duffy M, Patel NK, Read CM, Francis RH, Lane AI, Murugesh S, Jacob A.

Otol Neurotol. 2017 Jan;38(1):139-146.


Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.

Villamar Cruz O, Prudnikova TY, Araiza-Olivera D, Perez-Plasencia C, Johnson N, Bernhardy AJ, Slifker M, Renner C, Chernoff J, Arias-Romero LE.

Oncotarget. 2016 Nov 22;7(47):76590-76603. doi: 10.18632/oncotarget.12576.


PAK2 promotes migration and proliferation of salivary gland adenoid cystic carcinoma.

Deng WW, Wu L, Bu LL, Liu JF, Li YC, Ma SR, Yu GT, Mao L, Zhang WF, Sun ZJ.

Am J Transl Res. 2016 Aug 15;8(8):3387-97. eCollection 2016.


High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma.

Li C, Chen J, Wang Y, Song G, Xiao C, Yan D, Zhong L, Sun X, Wang X, Yu F, Yu Y, Tang H, Peng Z.

Oncotarget. 2016 Jul 19;7(29):46042-46055. doi: 10.18632/oncotarget.10017.


Altered function of monocytes/macrophages in patients with autoimmune hepatitis.

Lin R, Zhang J, Zhou L, Wang B.

Mol Med Rep. 2016 May;13(5):3874-80. doi: 10.3892/mmr.2016.4998. Epub 2016 Mar 17.


Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma.

Al-Maghrabi J, Emam E, Gomaa W, Al-Qaydy D, Al-Maghrabi B, Buhmeida A, Abuzenadah A, Al-Qahtani M, Al-Ahwal M.

Int J Clin Exp Pathol. 2015 Dec 1;8(12):15895-902. eCollection 2015.


A new role for cofilin in retinal neovascularization.

Kumar R, Janjanam J, Singh NK, Rao GN.

J Cell Sci. 2016 Mar 15;129(6):1234-49. doi: 10.1242/jcs.179382. Epub 2016 Feb 8.


Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma.

Liu W, Liu Y, Liu H, Zhang W, Fu Q, Xu J, Gu J.

J Biol Chem. 2015 Nov 20;290(47):28489-501. doi: 10.1074/jbc.M115.658237. Epub 2015 Oct 6.


PAK1 and CtBP1 Regulate the Coupling of Neuronal Activity to Muscle Chromatin and Gene Expression.

Thomas JL, Moncollin V, Ravel-Chapuis A, Valente C, Corda D, Méjat A, Schaeffer L.

Mol Cell Biol. 2015 Dec;35(24):4110-20. doi: 10.1128/MCB.00354-15. Epub 2015 Sep 28.


p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.

Radu M, Lyle K, Hoeflich KP, Villamar-Cruz O, Koeppen H, Chernoff J.

Mol Cell Biol. 2015 Dec;35(23):3990-4005. doi: 10.1128/MCB.00630-15. Epub 2015 Sep 21.


Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy.

Cabet E, Batonnet-Pichon S, Delort F, Gausserès B, Vicart P, Lilienbaum A.

PLoS One. 2015 Sep 2;10(9):e0137009. doi: 10.1371/journal.pone.0137009. eCollection 2015.


Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells.

Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J.

Oncogene. 2016 Apr 28;35(17):2178-85. doi: 10.1038/onc.2015.278. Epub 2015 Aug 10.


p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.

Siu MK, Kong DS, Ngai SY, Chan HY, Jiang L, Wong ES, Liu SS, Chan KK, Ngan HY, Cheung AN.

PLoS One. 2015 Jul 28;10(7):e0133467. doi: 10.1371/journal.pone.0133467. eCollection 2015.


The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.

Selamat W, Tay PL, Baskaran Y, Manser E.

PLoS One. 2015 Jun 11;10(6):e0129634. doi: 10.1371/journal.pone.0129634. eCollection 2015.

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