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Items: 1 to 20 of 134

1.

Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target.

Molinos-Albert LM, Clotet B, Blanco J, Carrillo J.

Front Immunol. 2017 Sep 19;8:1154. doi: 10.3389/fimmu.2017.01154. eCollection 2017. Review.

2.

Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1.

Mühle M, Lehmann M, Hoffmann K, Stern D, Kroniger T, Luttmann W, Denner J.

PLoS One. 2017 Mar 10;12(3):e0173454. doi: 10.1371/journal.pone.0173454. eCollection 2017.

3.

Vaccine nanoparticles for protection against HIV infection.

Aikins ME, Bazzill J, Moon JJ.

Nanomedicine (Lond). 2017 Mar;12(6):673-682. doi: 10.2217/nnm-2016-0381. Epub 2017 Feb 21. Review.

PMID:
28244816
4.

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.

Irimia A, Serra AM, Sarkar A, Jacak R, Kalyuzhniy O, Sok D, Saye-Francisco KL, Schiffner T, Tingle R, Kubitz M, Adachi Y, Stanfield RL, Deller MC, Burton DR, Schief WR, Wilson IA.

PLoS Pathog. 2017 Feb 22;13(2):e1006212. doi: 10.1371/journal.ppat.1006212. eCollection 2017 Feb.

5.

Peripheral Membrane Interactions Boost the Engagement by an Anti-HIV-1 Broadly Neutralizing Antibody.

Rujas E, Caaveiro JM, Insausti S, García-Porras M, Tsumoto K, Nieva JL.

J Biol Chem. 2017 Mar 31;292(13):5571-5583. doi: 10.1074/jbc.M117.775429. Epub 2017 Feb 17.

PMID:
28213514
6.

Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif.

Molinos-Albert LM, Bilbao E, Agulló L, Marfil S, García E, Rodríguez de la Concepción ML, Izquierdo-Useros N, Vilaplana C, Nieto-Garai JA, Contreras FX, Floor M, Cardona PJ, Martinez-Picado J, Clotet B, Villà-Freixa J, Lorizate M, Carrillo J, Blanco J.

Sci Rep. 2017 Jan 13;7:40800. doi: 10.1038/srep40800.

7.

Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface.

Rujas E, Caaveiro JM, Partida-Hanon A, Gulzar N, Morante K, Apellániz B, García-Porras M, Bruix M, Tsumoto K, Scott JK, Jiménez MÁ, Nieva JL.

Sci Rep. 2016 Dec 1;6:38177. doi: 10.1038/srep38177.

8.

Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer.

Parajuli B, Acharya K, Yu R, Ngo B, Rashad AA, Abrams CF, Chaiken IM.

Biochemistry. 2016 Nov 8;55(44):6100-6114. Epub 2016 Oct 27.

9.

Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.

Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB 3rd, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF.

EBioMedicine. 2016 Oct;12:196-207. doi: 10.1016/j.ebiom.2016.08.045. Epub 2016 Aug 31.

10.

Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles.

Louis JM, Baber JL, Ghirlando R, Aniana A, Bax A, Roche J.

PLoS One. 2016 Aug 11;11(8):e0160597. doi: 10.1371/journal.pone.0160597. eCollection 2016.

11.

Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity.

Donius LR, Cheng Y, Choi J, Sun ZY, Hanson M, Zhang M, Gierahn TM, Marquez S, Uduman M, Kleinstein SH, Irvine D, Love JC, Reinherz EL, Kim M.

J Virol. 2016 Sep 12;90(19):8875-90. doi: 10.1128/JVI.01089-16. Print 2016 Oct 1.

12.

An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene.

Sun Z, Zhu Y, Wang Q, Ye L, Dai Y, Su S, Yu F, Ying T, Yang C, Jiang S, Lu L.

Emerg Microbes Infect. 2016 Jun 22;5:e65. doi: 10.1038/emi.2016.86.

13.

Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.

Zhang R, Verkoczy L, Wiehe K, Munir Alam S, Nicely NI, Santra S, Bradley T, Pemble CW 4th, Zhang J, Gao F, Montefiori DC, Bouton-Verville H, Kelsoe G, Larimore K, Greenberg PD, Parks R, Foulger A, Peel JN, Luo K, Lu X, Trama AM, Vandergrift N, Tomaras GD, Kepler TB, Moody MA, Liao HX, Haynes BF.

Sci Transl Med. 2016 Apr 27;8(336):336ra62. doi: 10.1126/scitranslmed.aaf0618.

14.

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.

Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, Pegu A, Rudicell RS, Shi W, Wang K, Yang Y, Alger M, Bender MF, Carlton K, Cooper JW, Blinn J, Eudailey J, Lloyd K, Parks R, Alam SM, Haynes BF, Padte NN, Yu J, Ho DD, Huang J, Connors M, Schwartz RM, Mascola JR, Kwong PD.

J Virol. 2016 Jun 10;90(13):5899-914. doi: 10.1128/JVI.03246-15. Print 2016 Jul 1.

15.

Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41.

Yi HA, Fochtman BC, Rizzo RC, Jacobs A.

Curr HIV Res. 2016;14(3):283-94. Review.

16.

Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.

Irimia A, Sarkar A, Stanfield RL, Wilson IA.

Immunity. 2016 Jan 19;44(1):21-31. doi: 10.1016/j.immuni.2015.12.001. Epub 2016 Jan 5.

17.

Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10.

Rujas E, Gulzar N, Morante K, Tsumoto K, Scott JK, Nieva JL, Caaveiro JM.

J Virol. 2015 Dec;89(23):11975-89. doi: 10.1128/JVI.01793-15. Epub 2015 Sep 16.

18.
19.

A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS.

AlSalmi W, Mahalingam M, Ananthaswamy N, Hamlin C, Flores D, Gao G, Rao VB.

J Biol Chem. 2015 Aug 7;290(32):19780-95. doi: 10.1074/jbc.M115.656611. Epub 2015 Jun 18.

20.

Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.

Vassell R, He Y, Vennakalanti P, Dey AK, Zhuang M, Wang W, Sun Y, Biron-Sorek Z, Srivastava IK, LaBranche CC, Montefiori DC, Barnett SW, Weiss CD.

PLoS One. 2015 Jun 18;10(6):e0128562. doi: 10.1371/journal.pone.0128562. eCollection 2015.

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