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Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets.

Unanue ER.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.MCHD-0048-2016.


The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.

Unanue ER, Ferris ST, Carrero JA.

Immunol Rev. 2016 Jul;272(1):183-201. doi: 10.1111/imr.12430. Review.


Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?).

Wagner DH.

Clin Exp Immunol. 2016 Sep;185(3):271-80. doi: 10.1111/cei.12819. Epub 2016 Jul 25. Review.


Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Haddad CS, Bhattacharya P, Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Elshabrawy HA, Epstein AL, Prabhakar BS.

Autoimmunity. 2016 Aug;49(5):298-311. doi: 10.1080/08916934.2016.1183657. Epub 2016 May 31.


Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.

Wan X, Thomas JW, Unanue ER.

J Exp Med. 2016 May 30;213(6):967-78. doi: 10.1084/jem.20151869. Epub 2016 May 2.


Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.

Yang Y, Chan L.

Endocr Rev. 2016 Jun;37(3):190-222. doi: 10.1210/er.2015-1116. Epub 2016 Apr 1.


Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse.

Ferris ST, Carrero JA, Unanue ER.

J Autoimmun. 2016 Jul;71:19-25. doi: 10.1016/j.jaut.2016.03.007. Epub 2016 Mar 24. Review.


Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST, Wan X, Kanekura K, Carrero JA, Urano F, Unanue ER.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5496-502. doi: 10.1073/pnas.1515954112. Epub 2015 Aug 31.


Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model.

Gibson VB, Nikolic T, Pearce VQ, Demengeot J, Roep BO, Peakman M.

Clin Exp Immunol. 2015 Dec;182(3):251-60. doi: 10.1111/cei.12687. Epub 2015 Sep 17.


Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes.

Williams JM, Bonami RH, Hulbert C, Thomas JW.

J Immunol. 2015 Aug 1;195(3):853-64. doi: 10.4049/jimmunol.1403114. Epub 2015 Jun 24.


Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.

Hoelen H, Zaldumbide A, van Leeuwen WF, Torfs EC, Engelse MA, Hassan C, Lebbink RJ, de Koning EJ, Resssing ME, de Ru AH, van Veelen PA, Hoeben RC, Roep BO, Wiertz EJ.

PLoS One. 2015 Jun 24;10(6):e0128206. doi: 10.1371/journal.pone.0128206. eCollection 2015.


T cells in the control of organ-specific autoimmunity.

Bluestone JA, Bour-Jordan H, Cheng M, Anderson M.

J Clin Invest. 2015 Jun;125(6):2250-60. doi: 10.1172/JCI78089. Epub 2015 May 18. Review.


BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells.

Sarikonda G, Fousteri G, Sachithanantham S, Miller JF, Dave A, Juntti T, Coppieters KT, von Herrath M.

PLoS One. 2014 Nov 13;9(11):e112242. doi: 10.1371/journal.pone.0112242. eCollection 2014.


A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes.

Ferris ST, Carrero JA, Mohan JF, Calderon B, Murphy KM, Unanue ER.

Immunity. 2014 Oct 16;41(4):657-69. doi: 10.1016/j.immuni.2014.09.012.


Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex.

Kralovicova J, Lages A, Patel A, Dhir A, Buratti E, Searle M, Vorechovsky I.

Nucleic Acids Res. 2014 Jul;42(12):8161-73. doi: 10.1093/nar/gku507. Epub 2014 Jun 17.


Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells.

Perez S, Fishman S, Bordowitz A, Margalit A, Wong FS, Gross G.

Immunology. 2014 Dec;143(4):609-17. doi: 10.1111/imm.12340.


γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.

Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK.

Mol Immunol. 2014 Aug;60(2):116-28. doi: 10.1016/j.molimm.2014.04.007. Epub 2014 May 20.


Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention.

Ikegami H, Noso S, Babaya N, Kawabata Y.

J Diabetes Investig. 2011 Nov 30;2(6):415-20. doi: 10.1111/j.2040-1124.2011.00176.x. Review.


MAS-1 adjuvant immunotherapy generates robust Th2 type and regulatory immune responses providing long-term protection from diabetes in late-stage pre-diabetic NOD mice.

Zhang L, Londono P, Yu L, Grimes S, Blackburn P, Gottlieb P, Eisenbarth GS.

Autoimmunity. 2014 Aug;47(5):341-50. doi: 10.3109/08916934.2014.910768. Epub 2014 May 1.


In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis.

Garabatos N, Alvarez R, Carrillo J, Carrascal J, Izquierdo C, Chapman HD, Presa M, Mora C, Serreze DV, Verdaguer J, Stratmann T.

J Immunol. 2014 Apr 1;192(7):3080-90. doi: 10.4049/jimmunol.1301053. Epub 2014 Mar 7.

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