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Items: 16


Ribosomopathy-like properties of murine and human cancers.

Kulkarni S, Dolezal JM, Wang H, Jackson L, Lu J, Frodey BP, Dosunmu-Ogunbi A, Li Y, Fromherz M, Kang A, Santana-Santos L, Benos PV, Prochownik EV.

PLoS One. 2017 Aug 18;12(8):e0182705. doi: 10.1371/journal.pone.0182705. eCollection 2017.


PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription.

Liang H, Chen X, Yin Q, Ruan D, Zhao X, Zhang C, McNutt MA, Yin Y.

Nat Commun. 2017 Mar 23;8:14771. doi: 10.1038/ncomms14771.


Insights into the regulation of neuronal viability by nucleophosmin/B23.

Pfister JA, D'Mello SR.

Exp Biol Med (Maywood). 2015 Jun;240(6):774-86. doi: 10.1177/1535370215579168. Epub 2015 Apr 22. Review.


Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription.

Holmberg Olausson K, Nistér M, Lindström MS.

J Biol Chem. 2014 Dec 12;289(50):34601-19. doi: 10.1074/jbc.M114.569244. Epub 2014 Oct 27.


Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF.

Dichamp I, Séité P, Agius G, Barbarin A, Beby-Defaux A.

PLoS One. 2014 May 5;9(5):e96136. doi: 10.1371/journal.pone.0096136. eCollection 2014.


The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis.

Ponti D, Bellenchi GC, Puca R, Bastianelli D, Maroder M, Ragona G, Roussel P, Thiry M, Mercola D, Calogero A.

PLoS One. 2014 May 1;9(5):e96037. doi: 10.1371/journal.pone.0096037. eCollection 2014.


ARF and p53 coordinate tumor suppression of an oncogenic IFN-β-STAT1-ISG15 signaling axis.

Forys JT, Kuzmicki CE, Saporita AJ, Winkeler CL, Maggi LB Jr, Weber JD.

Cell Rep. 2014 Apr 24;7(2):514-26. doi: 10.1016/j.celrep.2014.03.026. Epub 2014 Apr 13.


Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.

Poletto M, Lirussi L, Wilson DM 3rd, Tell G.

Mol Biol Cell. 2014 May;25(10):1641-52. doi: 10.1091/mbc.E13-12-0717. Epub 2014 Mar 19.


The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation.

Kuchenreuther MJ, Weber JD.

Oncogene. 2014 Jan 16;33(3):300-7. doi: 10.1038/onc.2012.601. Epub 2013 Jan 14.


Cathepsin K-Cre causes unexpected germline deletion of genes in mice.

Winkeler CL, Kladney RD, Maggi LB Jr, Weber JD.

PLoS One. 2012;7(7):e42005. doi: 10.1371/journal.pone.0042005. Epub 2012 Jul 31.


Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.

Dai MS, Challagundla KB, Sun XX, Palam LR, Zeng SX, Wek RC, Lu H.

J Biol Chem. 2012 May 18;287(21):17120-9. doi: 10.1074/jbc.M111.311902. Epub 2012 Mar 30.


Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.

Miceli AP, Saporita AJ, Weber JD.

Mol Cell Biol. 2012 Jan;32(2):348-64. doi: 10.1128/MCB.06030-11. Epub 2011 Nov 7.


RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.

Saporita AJ, Chang HC, Winkeler CL, Apicelli AJ, Kladney RD, Wang J, Townsend RR, Michel LS, Weber JD.

Cancer Res. 2011 Nov 1;71(21):6708-17. doi: 10.1158/0008-5472.CAN-11-1472. Epub 2011 Sep 21.


The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.

Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN.

PLoS One. 2010 Dec 30;5(12):e15755. doi: 10.1371/journal.pone.0015755.


APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G.

Mol Cell Biol. 2009 Apr;29(7):1834-54. doi: 10.1128/MCB.01337-08. Epub 2009 Feb 2.


Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus.

Zimmerman RS, Rosenberg N.

J Virol. 2008 Sep;82(17):8383-91. doi: 10.1128/JVI.00348-08. Epub 2008 Jun 25.

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