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Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation.

Huang J, Mis MA, Tanaka B, Adi T, Estacion M, Liu S, Walker S, Dib-Hajj SD, Waxman SG.

Sci Rep. 2018 Jan 29;8(1):1811. doi: 10.1038/s41598-018-20221-7.


Physical basis of specificity and delayed binding of a subtype selective sodium channel inhibitor.

Corry B.

Sci Rep. 2018 Jan 22;8(1):1356. doi: 10.1038/s41598-018-19850-9.


Breaking barriers to novel analgesic drug development.

Yekkirala AS, Roberson DP, Bean BP, Woolf CJ.

Nat Rev Drug Discov. 2017 Aug;16(8):545-564. doi: 10.1038/nrd.2017.87. Epub 2017 Jun 9. Review. Erratum in: Nat Rev Drug Discov. 2017 Oct 06;:.


Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development.

Tanaka BS, Nguyen PT, Zhou EY, Yang Y, Yarov-Yarovoy V, Dib-Hajj SD, Waxman SG.

J Biol Chem. 2017 Jun 2;292(22):9262-9272. doi: 10.1074/jbc.M117.778779. Epub 2017 Apr 5.


Sodium channels in pain disorders: pathophysiology and prospects for treatment.

Dib-Hajj SD, Geha P, Waxman SG.

Pain. 2017 Apr;158 Suppl 1:S97-S107. doi: 10.1097/j.pain.0000000000000854. No abstract available.


Network topology of NaV1.7 mutations in sodium channel-related painful disorders.

Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G; PROPANE Study Group.

BMC Syst Biol. 2017 Feb 24;11(1):28. doi: 10.1186/s12918-016-0382-0.


Nonlinear effects of hyperpolarizing shifts in activation of mutant Nav1.7 channels on resting membrane potential.

Estacion M, Waxman SG.

J Neurophysiol. 2017 Apr 1;117(4):1702-1712. doi: 10.1152/jn.00898.2016. Epub 2017 Feb 1.


MicroRNA-30b regulates expression of the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in the rat.

Shao J, Cao J, Wang J, Ren X, Su S, Li M, Li Z, Zhao Q, Zang W.

Mol Pain. 2016 Oct 19;12. pii: 1744806916671523. Print 2016.


Slipped Distal Femoral Epiphysis in Congenital Insensitivity to Pain.

Shaikh MJ, Rex C, Vignesh R, Chavan M.

J Orthop Case Rep. 2016 Apr-Jun;6(2):78-80.


Ion channelopathies in functional GI disorders.

Beyder A, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G581-G586. doi: 10.1152/ajpgi.00237.2016. Epub 2016 Aug 11. Review.


The CRISPR/Cas9 system for gene editing and its potential application in pain research.

Sun L, Lutz BM, Tao YX.

Transl Perioper Pain Med. 2016;1(3):22-33.


Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.

Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, Doyle R, Printzenhoff D, Lin Z, Marron BE, West C, Swain NA, Storer RI, Stupple PA, Castle NA, Hounshell JA, Rivara M, Randall A, Dib-Hajj SD, Krafte D, Waxman SG, Patel MK, Butt RP, Stevens EB.

PLoS One. 2016 Apr 6;11(4):e0152405. doi: 10.1371/journal.pone.0152405. eCollection 2016.


Managing Chronic Pain in Special Populations with Emphasis on Pediatric, Geriatric, and Drug Abuser Populations.

Baumbauer KM, Young EE, Starkweather AR, Guite JW, Russell BS, Manworren RC.

Med Clin North Am. 2016 Jan;100(1):183-97. doi: 10.1016/j.mcna.2015.08.013. Review.


The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells.

Boisvert EM, Engle SJ, Hallowell SE, Liu P, Wang ZW, Li XJ.

Sci Rep. 2015 Nov 19;5:16821. doi: 10.1038/srep16821.


Human pain and genetics: some basics.

James S.

Br J Pain. 2013 Nov;7(4):171-8. doi: 10.1177/2049463713506408.


Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin.

Rice FL, Albrecht PJ, Wymer JP, Black JA, Merkies IS, Faber CG, Waxman SG.

Mol Pain. 2015 May 9;11:26. doi: 10.1186/s12990-015-0024-3.


Synthesis and analgesic effects of μ-TRTX-Hhn1b on models of inflammatory and neuropathic pain.

Liu Y, Tang J, Zhang Y, Xun X, Tang D, Peng D, Yi J, Liu Z, Shi X.

Toxins (Basel). 2014 Aug 13;6(8):2363-78. doi: 10.3390/toxins6082363.


Epigenetic regulation of persistent pain.

Bai G, Ren K, Dubner R.

Transl Res. 2015 Jan;165(1):177-99. doi: 10.1016/j.trsl.2014.05.012. Epub 2014 May 29. Review.


An Egyptian child with erythromelalgia responding to a new line of treatment: a case report and review of the literature.

Al-Minshawy SM, El-Mazary AA.

J Med Case Rep. 2014 Feb 25;8:69. doi: 10.1186/1752-1947-8-69.

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