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Items: 1 to 20 of 93

1.

High-Affinity Functional Fluorescent Ligands for Human β-Adrenoceptors.

Mitronova GY, Lukinavičius G, Butkevich AN, Kohl T, Belov VN, Lehnart SE, Hell SW.

Sci Rep. 2017 Sep 26;7(1):12319. doi: 10.1038/s41598-017-12468-3.

2.

Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging.

Harada K, Ito M, Wang X, Tanaka M, Wongso D, Konno A, Hirai H, Hirase H, Tsuboi T, Kitaguchi T.

Sci Rep. 2017 Aug 4;7(1):7351. doi: 10.1038/s41598-017-07820-6.

3.

Interrogating cyclic AMP signaling using optical approaches.

Jiang JY, Falcone JL, Curci S, Hofer AM.

Cell Calcium. 2017 Jun;64:47-56. doi: 10.1016/j.ceca.2017.02.010. Epub 2017 Mar 1. Review.

PMID:
28274483
4.

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21.

5.

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27.

6.

Molecular Signature That Determines the Acute Tolerance of G Protein-Coupled Receptors.

Min C, Zhang X, Zheng M, Sun N, Acharya S, Zhang X, Kim KM.

Biomol Ther (Seoul). 2017 May 1;25(3):239-248. doi: 10.4062/biomolther.2016.193.

7.

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.

Varandas KC, Irannejad R, von Zastrow M.

Curr Biol. 2016 Dec 5;26(23):3129-3142. doi: 10.1016/j.cub.2016.09.052. Epub 2016 Nov 10.

PMID:
27839977
8.

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.

Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4.

9.

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Uses its C-Terminus to Regulate the A2B Adenosine Receptor.

Watson MJ, Lee SL, Marklew AJ, Gilmore RC, Gentzsch M, Sassano MF, Gray MA, Tarran R.

Sci Rep. 2016 Jun 9;6:27390. doi: 10.1038/srep27390.

10.

Functional Regulation of Dopamine D₃ Receptor through Interaction with PICK1.

Zheng M, Zhang X, Min C, Choi BG, Oh IJ, Kim KM.

Biomol Ther (Seoul). 2016 Sep 1;24(5):475-81. doi: 10.4062/biomolther.2016.015.

11.

A novel biosensor to study cAMP dynamics in cilia and flagella.

Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D.

Elife. 2016 Mar 22;5. pii: e14052. doi: 10.7554/eLife.14052.

12.

Contributions of protein kinases and β-arrestin to termination of protease-activated receptor 2 signaling.

Jung SR, Seo JB, Deng Y, Asbury CL, Hille B, Koh DS.

J Gen Physiol. 2016 Mar;147(3):255-71. doi: 10.1085/jgp.201511477.

13.

Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.

Chay A, Zamparo I, Koschinski A, Zaccolo M, Blackwell KT.

PLoS Comput Biol. 2016 Feb 22;12(2):e1004735. doi: 10.1371/journal.pcbi.1004735. eCollection 2016 Feb.

14.

Adrenergic ligands that block oviposition in the cattle tick Rhipicephalus microplus affect ovary contraction.

Cossío-Bayúgar R, Miranda-Miranda E, Fernández-Rubalcaba M, Narváez Padilla V, Reynaud E.

Sci Rep. 2015 Oct 12;5:15109. doi: 10.1038/srep15109.

15.

Analyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKs.

Gurevich VV, Gurevich EV.

Crit Rev Biochem Mol Biol. 2015;50(5):440-52. doi: 10.3109/10409238.2015.1067185. Review.

16.

Estimating the magnitude of near-membrane PDE4 activity in living cells.

Xin W, Feinstein WP, Britain AL, Ochoa CD, Zhu B, Richter W, Leavesley SJ, Rich TC.

Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C415-24. doi: 10.1152/ajpcell.00090.2015. Epub 2015 Jul 22.

17.

GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain.

Ahmed MR, Bychkov E, Li L, Gurevich VV, Gurevich EV.

Sci Rep. 2015 Jun 4;5:10920. doi: 10.1038/srep10920.

18.

Cell, isoform, and environment factors shape gradients and modulate chemotaxis.

Chang SL, Cavnar SP, Takayama S, Luker GD, Linderman JJ.

PLoS One. 2015 Apr 24;10(4):e0123450. doi: 10.1371/journal.pone.0123450. eCollection 2015. Erratum in: PLoS One. 2017 Mar 14;12 (3):e0174189.

19.

Roflumilast combined with adenosine increases mucosal hydration in human airway epithelial cultures after cigarette smoke exposure.

Tyrrell J, Qian X, Freire J, Tarran R.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1068-77. doi: 10.1152/ajplung.00395.2014. Epub 2015 Mar 20.

20.

Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.

Gimenez LE, Baameur F, Vayttaden SJ, Clark RB.

Mol Pharmacol. 2015 Jun;87(6):954-64. doi: 10.1124/mol.114.096800. Epub 2015 Mar 17.

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