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Items: 1 to 20 of 22


An update on the role of intestinal cytochrome P450 enzymes in drug disposition.

Xie F, Ding X, Zhang QY.

Acta Pharm Sin B. 2016 Sep;6(5):374-383. Review.


Oral exposure to commercially available coal tar-based pavement sealcoat induces murine genetic damage and mutations.

Long AS, Watson M, Arlt VM, White PA.

Environ Mol Mutagen. 2016 Aug;57(7):535-45. doi: 10.1002/em.22032.


Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.

Brandstätter O, Schanz O, Vorac J, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H, Förster I.

Sci Rep. 2016 May 17;6:26091. doi: 10.1038/srep26091.


Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay.

Long AS, Lemieux CL, Arlt VM, White PA.

Toxicol Appl Pharmacol. 2016 Jan 1;290:31-42. doi: 10.1016/j.taap.2015.11.010.


Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.

Siddens LK, Bunde KL, Harper TA Jr, McQuistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM.

Toxicol Appl Pharmacol. 2015 Sep 1;287(2):149-60. doi: 10.1016/j.taap.2015.05.019.


Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer.

Diggs DL, Myers JN, Banks LD, Niaz MS, Hood DB, Roberts LJ 2nd, Ramesh A.

J Nutr Biochem. 2013 Dec;24(12):2051-63. doi: 10.1016/j.jnutbio.2013.07.006.


Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.

Nebert DW, Shi Z, Gálvez-Peralta M, Uno S, Dragin N.

Mol Pharmacol. 2013 Sep;84(3):304-13. doi: 10.1124/mol.113.086637. Review.


Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.

Dong H, Shertzer HG, Genter MB, Gonzalez FJ, Vasiliou V, Jefcoate C, Nebert DW.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):727-32. doi: 10.1016/j.bbrc.2013.05.051.


TLR2 controls intestinal carcinogen detoxication by CYP1A1.

Do KN, Fink LN, Jensen TE, Gautier L, Parlesak A.

PLoS One. 2012;7(3):e32309. doi: 10.1371/journal.pone.0032309.


Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in ApcMin mouse model of colon cancer.

Diggs DL, Harris KL, Rekhadevi PV, Ramesh A.

Tumour Biol. 2012 Aug;33(4):1255-60. doi: 10.1007/s13277-012-0375-6.


Polycyclic aromatic hydrocarbons and digestive tract cancers: a perspective.

Diggs DL, Huderson AC, Harris KL, Myers JN, Banks LD, Rekhadevi PV, Niaz MS, Ramesh A.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2011 Oct;29(4):324-57. doi: 10.1080/10590501.2011.629974. Review.


Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice.

Ozeki J, Uno S, Ogura M, Choi M, Maeda T, Sakurai K, Matsuo S, Amano S, Nebert DW, Makishima M.

Toxicology. 2011 Feb 4;280(1-2):10-7. doi: 10.1016/j.tox.2010.11.003.


In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.

Curran CP, Vorhees CV, Williams MT, Genter MB, Miller ML, Nebert DW.

Toxicol Sci. 2011 Jan;119(1):189-208. doi: 10.1093/toxsci/kfq314.


The role of small-intestinal P450 enzymes in protection against systemic exposure of orally administered benzo[a]pyrene.

Fang C, Zhang QY.

J Pharmacol Exp Ther. 2010 Jul;334(1):156-63. doi: 10.1124/jpet.110.167742.


Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene.

Shi Z, Dragin N, Gálvez-Peralta M, Jorge-Nebert LF, Miller ML, Wang B, Nebert DW.

Mol Pharmacol. 2010 Jul;78(1):46-57. doi: 10.1124/mol.110.063438.


Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.

Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW.

Int J Cancer. 2010 Nov 15;127(10):2334-50. doi: 10.1002/ijc.25222.


CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.

Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW.

Toxicol Appl Pharmacol. 2009 May 15;237(1):119-26. doi: 10.1016/j.taap.2009.03.001.


Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.

Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW.

Mol Pharmacol. 2009 Mar;75(3):555-67. doi: 10.1124/mol.108.051888. Erratum in: Mol Pharmacol. 2009 Aug;76(2):452.


Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells.

Taylor RT, Wang F, Hsu EL, Hankinson O.

Toxicol Sci. 2009 Jan;107(1):1-8. doi: 10.1093/toxsci/kfn217.

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