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Items: 1 to 20 of 56

1.

Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.

Ulmasov B, Neuschwander-Tetri BA, Lai J, Monastyrskiy V, Bhat T, Yates MP, Oliva J, Prinsen MJ, Ruminski PG, Griggs DW.

Cell Mol Gastroenterol Hepatol. 2016 Mar 16;2(4):499-518. doi: 10.1016/j.jcmgh.2016.03.004.

2.

Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice.

Delhove JM, Buckley SM, Perocheau DP, Karda R, Arbuthnot P, Henderson NC, Waddington SN, McKay TR.

Sci Rep. 2017 Feb 3;7:41874. doi: 10.1038/srep41874.

3.

Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis.

Joshi N, Kopec AK, Cline-Fedewa H, Luyendyk JP.

Toxicology. 2017 Feb 15;377:73-80. doi: 10.1016/j.tox.2016.12.009.

PMID:
28049044
4.

αvβ1 integrin as a novel therapeutic target for tissue fibrosis.

Song KH, Cho SJ, Song JY.

Ann Transl Med. 2016 Oct;4(20):411.

5.

Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis.

Saneyasu T, Akhtar R, Sakai T.

Biomed Res Int. 2016;2016:2646212. Review.

6.

Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.

Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G.

JCI Insight. 2016 Jul 21;1(11). pii: e87336.

7.

Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia.

Kerola A, Lampela H, Lohi J, Heikkilä P, Mutanen A, Hagström J, Tervahartiala T, Sorsa T, Haglund C, Jalanko H, Pakarinen MP.

J Pathol Clin Res. 2016 May 12;2(3):187-98. doi: 10.1002/cjp2.50.

8.
9.

αv integrins: key regulators of tissue fibrosis.

Conroy KP, Kitto LJ, Henderson NC.

Cell Tissue Res. 2016 Sep;365(3):511-9. doi: 10.1007/s00441-016-2407-9. Epub 2016 May 2. Review.

10.

α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis.

Sun KH, Chang Y, Reed NI, Sheppard D.

Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L824-36. doi: 10.1152/ajplung.00350.2015.

PMID:
26944089
11.

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.

Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP.

Blood. 2016 Jun 2;127(22):2751-62. doi: 10.1182/blood-2015-09-670703.

PMID:
26921287
12.

Promising Therapy Candidates for Liver Fibrosis.

Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T.

Front Physiol. 2016 Feb 16;7:47. doi: 10.3389/fphys.2016.00047. Review.

13.

Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.

Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters PJ, Wallace W, Alberti S, Nordheim A, Jenkins G.

J Biol Chem. 2016 Apr 29;291(18):9540-53. doi: 10.1074/jbc.M115.692368.

14.

Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis.

Iwasaki A, Sakai K, Moriya K, Sasaki T, Keene DR, Akhtar R, Miyazono T, Yasumura S, Watanabe M, Morishita S, Sakai T.

J Biol Chem. 2016 Jan 1;291(1):72-88. doi: 10.1074/jbc.M115.691519.

15.

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.

Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y.

Hepatology. 2016 Jan;63(1):217-32. doi: 10.1002/hep.28274.

16.

New therapies for hepatic fibrosis.

Koyama Y, Brenner DA.

Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S75-9. doi: 10.1016/j.clinre.2015.06.011. Review.

17.

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models.

Li Y, Drabsch Y, Pujuguet P, Ren J, van Laar T, Zhang L, van Dam H, Clément-Lacroix P, Ten Dijke P.

Breast Cancer Res. 2015 Feb 25;17:28. doi: 10.1186/s13058-015-0537-8.

18.

Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts.

Sheppard D.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S21-3. doi: 10.1513/AnnalsATS.201406-245MG. Review.

19.

CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.

Kim KH, Chen CC, Alpini G, Lau LF.

J Clin Invest. 2015 May;125(5):1886-900. doi: 10.1172/JCI79327.

20.

Assessment of the effect of potential antifibrotic compounds on total and αVβ6 integrin-mediated TGF-β activation.

Porte J, Jenkins G.

Pharmacol Res Perspect. 2014 Aug;2(4):e00030. doi: 10.1002/prp2.30.

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