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Items: 1 to 20 of 21

1.

Allosteric Regulation of Mammalian Pantothenate Kinase.

Subramanian C, Yun MK, Yao J, Sharma LK, Lee RE, White SW, Jackowski S, Rock CO.

J Biol Chem. 2016 Oct 14;291(42):22302-22314.

PMID:
27555321
2.

Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.

Zano SP, Pate C, Frank M, Rock CO, Jackowski S.

Mol Genet Metab. 2015 Dec;116(4):281-8. doi: 10.1016/j.ymgme.2015.10.011.

3.

Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease.

Zizioli D, Tiso N, Guglielmi A, Saraceno C, Busolin G, Giuliani R, Khatri D, Monti E, Borsani G, Argenton F, Finazzi D.

Neurobiol Dis. 2016 Jan;85:35-48. doi: 10.1016/j.nbd.2015.10.010.

4.

Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.

Machado MV, Kruger L, Jewell ML, Michelotti GA, Pereira Tde A, Xie G, Moylan CA, Diehl AM.

Dig Dis Sci. 2016 Jan;61(1):137-48. doi: 10.1007/s10620-015-3871-x.

5.

Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.

Shumar SA, Fagone P, Alfonso-Pecchio A, Gray JT, Rehg JE, Jackowski S, Leonardi R.

PLoS One. 2015 Jun 8;10(6):e0130013. doi: 10.1371/journal.pone.0130013.

6.

Acanthocytosis and the c.680 A>G Mutation in the PANK2 Gene: A Study Enrolling a Cohort of PKAN Patients from the Dominican Republic.

Schiessl-Weyer J, Roa P, Laccone F, Kluge B, Tichy A, De Almeida Ribeiro E, Prohaska R, Stoeter P, Siegl C, Salzer U.

PLoS One. 2015 Apr 27;10(4):e0125861. doi: 10.1371/journal.pone.0125861.

7.

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients.

Santambrogio P, Dusi S, Guaraldo M, Rotundo LI, Broccoli V, Garavaglia B, Tiranti V, Levi S.

Neurobiol Dis. 2015 Sep;81:144-53. doi: 10.1016/j.nbd.2015.02.030.

8.

Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms.

Levi S, Finazzi D.

Front Pharmacol. 2014 May 7;5:99. doi: 10.3389/fphar.2014.00099. Review.

9.
10.

A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.

Pandey V, Turm H, Bekenstein U, Shifman S, Kadener S.

Front Cell Neurosci. 2013 Sep 9;7:146. doi: 10.3389/fncel.2013.00146. Erratum in: Front Cell Neurosci. 2013;7:187. Varun, Pandey [corrected to Pandey, Varun]; Hagit, Turm [corrected to Turm, Hagit]; Uriya, Bekenstein [corrected to Bekenstein, Uriya]; Sagiv, Shifman [corrected to Shifman, Sagiv]; Sebastian, Kadener [corrected to Kadener, Sebastian].

11.

Compartmentalization of mammalian pantothenate kinases.

Alfonso-Pecchio A, Garcia M, Leonardi R, Jackowski S.

PLoS One. 2012;7(11):e49509. doi: 10.1371/journal.pone.0049509.

12.

Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model.

Brunetti D, Dusi S, Morbin M, Uggetti A, Moda F, D'Amato I, Giordano C, d'Amati G, Cozzi A, Levi S, Hayflick S, Tiranti V.

Hum Mol Genet. 2012 Dec 15;21(24):5294-305. doi: 10.1093/hmg/dds380.

13.

Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.

Garcia M, Leonardi R, Zhang YM, Rehg JE, Jackowski S.

PLoS One. 2012;7(7):e40871. doi: 10.1371/journal.pone.0040871.

14.

Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.

Prohaska R, Sibon OC, Rudnicki DD, Danek A, Hayflick SJ, Verhaag EM, Vonk JJ, Margolis RL, Walker RH.

Neurobiol Dis. 2012 Jun;46(3):607-24. doi: 10.1016/j.nbd.2012.03.006. Review.

15.

A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy.

Fyfe JC, Al-Tamimi RA, Liu J, Schäffer AA, Agarwala R, Henthorn PS.

Neurogenetics. 2011 Aug;12(3):223-32. doi: 10.1007/s10048-011-0285-6.

16.

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

Leonardi R, Zhang YM, Yun MK, Zhou R, Zeng FY, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S.

Chem Biol. 2010 Aug 27;17(8):892-902. doi: 10.1016/j.chembiol.2010.06.006.

17.

Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse.

Polster BJ, Westaway SK, Nguyen TM, Yoon MY, Hayflick SJ.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):292-5. doi: 10.1016/j.ymgme.2010.07.016.

18.

Characterization of the human PANK2 promoter.

Polster BJ, Yoon MY, Hayflick SJ.

Gene. 2010 Oct 1;465(1-2):53-60. doi: 10.1016/j.gene.2010.06.011.

19.

Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state.

Leonardi R, Rehg JE, Rock CO, Jackowski S.

PLoS One. 2010 Jun 14;5(6):e11107. doi: 10.1371/journal.pone.0011107.

20.

Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus.

Takagi M, Tamaki H, Miyamoto Y, Leonardi R, Hanada S, Jackowski S, Chohnan S.

J Bacteriol. 2010 Jan;192(1):233-41. doi: 10.1128/JB.01021-09.

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