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DNA double strand break repair, aging and the chromatin connection.

Gorbunova V, Seluanov A.

Mutat Res. 2016 Jun;788:2-6. doi: 10.1016/j.mrfmmm.2016.02.004. Epub 2016 Feb 15. Review.


Programmed Cell Death Genes Are Linked to Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians.

Kim S, Simon E, Myers L, Hamm LL, Jazwinski SM.

Gerontology. 2016;62(5):519-29. doi: 10.1159/000443793. Epub 2016 Feb 26.


In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage.

Hare I, Gencheva M, Evans R, Fortney J, Piktel D, Vos JA, Howell D, Gibson LF.

Stem Cells Int. 2016;2016:8270464. doi: 10.1155/2016/8270464. Epub 2016 Jan 6.


DNA repair and aging: the impact of the p53 family.

Nicolai S, Rossi A, Di Daniele N, Melino G, Annicchiarico-Petruzzelli M, Raschellà G.

Aging (Albany NY). 2015 Dec;7(12):1050-65. Review.


DNA double-strand break repair is impaired in presenescent Syrian hamster fibroblasts.

Solovjeva L, Firsanov D, Vasilishina A, Chagin V, Pleskach N, Kropotov A, Svetlova M.

BMC Mol Biol. 2015 Oct 12;16:18. doi: 10.1186/s12867-015-0046-4.


Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence Signalling.

Dolan DW, Zupanic A, Nelson G, Hall P, Miwa S, Kirkwood TB, Shanley DP.

PLoS Comput Biol. 2015 May 28;11(5):e1004246. doi: 10.1371/journal.pcbi.1004246. eCollection 2015 May.


Aging and radiation: bad companions.

Hernández L, Terradas M, Camps J, Martín M, Tusell L, Genescà A.

Aging Cell. 2015 Apr;14(2):153-61. doi: 10.1111/acel.12306. Epub 2015 Feb 2. Review.


Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging.

Martín-Guerrero I, de Prado E, Lopez-Lopez E, Ardanaz M, Vitoria JC, Parada LA, García-Orad C, García-Orad A.

Age (Dordr). 2014;36(6):9730. doi: 10.1007/s11357-014-9730-4. Epub 2014 Nov 16.


Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age.

Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V.

PLoS Genet. 2014 Jul 17;10(7):e1004511. doi: 10.1371/journal.pgen.1004511. eCollection 2014 Jul.


Increased mammogram-induced DNA damage in mammary epithelial cells aged in vitro.

Hernández L, Terradas M, Martín M, Feijoo P, Soler D, Tusell L, Genescà A.

PLoS One. 2013 May 7;8(5):e63052. doi: 10.1371/journal.pone.0063052. Print 2013.


Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11800-5. doi: 10.1073/pnas.1200583109. Epub 2012 Jul 2.


Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.

Hsu JL, Leong PK, Ho YF, Hsu LC, Lu PH, Chen CS, Guh JH.

Cancer Lett. 2012 Jun 28;319(2):214-222. doi: 10.1016/j.canlet.2012.01.004. Epub 2012 Jan 17.


Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress.

Singh K, Matsuyama S, Drazba JA, Almasan A.

Autophagy. 2012 Feb 1;8(2):236-51. doi: 10.4161/auto.8.2.18600. Epub 2012 Feb 1.


Ku circles the telomere?

Sell C.

Aging (Albany NY). 2011 Apr;3(4):344-5. No abstract available.


Cellular stress response pathways and ageing: intricate molecular relationships.

Kourtis N, Tavernarakis N.

EMBO J. 2011 May 17;30(13):2520-31. doi: 10.1038/emboj.2011.162. Review.


A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related.

Freitas AA, Vasieva O, de Magalhães JP.

BMC Genomics. 2011 Jan 12;12:27. doi: 10.1186/1471-2164-12-27.


Microsatellite instability in Arabidopsis increases with plant development.

Golubov A, Yao Y, Maheshwari P, Bilichak A, Boyko A, Belzile F, Kovalchuk I.

Plant Physiol. 2010 Nov;154(3):1415-27. doi: 10.1104/pp.110.162933. Epub 2010 Sep 3.


The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation.

Liu J, Naegele JR, Lin SL.

Brain Res. 2009 Nov 3;1296:164-75. doi: 10.1016/j.brainres.2009.07.101. Epub 2009 Aug 4.


Increase in double-stranded DNA break-related foci in early-stage thymocytes of aged mice.

Hesse JE, Faulkner MF, Durdik JM.

Exp Gerontol. 2009 Oct;44(10):676-84. doi: 10.1016/j.exger.2009.06.009. Epub 2009 Jul 12.


DNA double-strand breaks: a potential causative factor for mammalian aging?

Li H, Mitchell JR, Hasty P.

Mech Ageing Dev. 2008 Jul-Aug;129(7-8):416-24. doi: 10.1016/j.mad.2008.02.002. Epub 2008 Feb 14. Review.

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