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Sodium channels in pain disorders: pathophysiology and prospects for treatment.

Dib-Hajj SD, Geha P, Waxman SG.

Pain. 2017 Apr;158 Suppl 1:S97-S107. doi: 10.1097/j.pain.0000000000000854. No abstract available.


The influence of sodium on pathophysiology of multiple sclerosis.

Zostawa J, Adamczyk J, Sowa P, Adamczyk-Sowa M.

Neurol Sci. 2017 Mar;38(3):389-398. doi: 10.1007/s10072-016-2802-8. Review.


Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain.

Brierley SM, Hughes PA, Harrington AM, Rychkov GY, Blackshaw LA.

Pharmaceuticals (Basel). 2010 Aug 26;3(9):2768-2798. Review.


The Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Nav1.7 Channel and the Molecular Pathogenesis of Inherited Erythromelalgia.

Huang CW, Lai HJ, Huang PY, Lee MJ, Kuo CC.

PLoS Biol. 2016 Sep 21;14(9):e1002561. doi: 10.1371/journal.pbio.1002561.


Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder.

Cannon A, Kurklinsky S, Guthrie KJ, Riegert-Johnson DL.

Case Rep Neurol Med. 2016;2016:9212369. doi: 10.1155/2016/9212369.


Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery.

Imbrici P, Liantonio A, Camerino GM, De Bellis M, Camerino C, Mele A, Giustino A, Pierno S, De Luca A, Tricarico D, Desaphy JF, Conte D.

Front Pharmacol. 2016 May 10;7:121. doi: 10.3389/fphar.2016.00121. Review.


Genetic neurological channelopathies: molecular genetics and clinical phenotypes.

Spillane J, Kullmann DM, Hanna MG.

J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):37-48. doi: 10.1136/jnnp-2015-311233. Epub 2015 Nov 11. Review.


Human pain and genetics: some basics.

James S.

Br J Pain. 2013 Nov;7(4):171-8. doi: 10.1177/2049463713506408.


Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.

Matson DJ, Hamamoto DT, Bregman H, Cooke M, DiMauro EF, Huang L, Johnson D, Li X, McDermott J, Morgan C, Wilenkin B, Malmberg AB, McDonough SI, Simone DA.

PLoS One. 2015 Sep 17;10(9):e0138140. doi: 10.1371/journal.pone.0138140.


Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin.

Rice FL, Albrecht PJ, Wymer JP, Black JA, Merkies IS, Faber CG, Waxman SG.

Mol Pain. 2015 May 9;11:26. doi: 10.1186/s12990-015-0024-3.


Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder.

Imai N, Miyake N, Saito Y, Kobayashi E, Ikawa M, Manaka S, Shiina M, Ogata K, Matsumoto N.

J Headache Pain. 2015;16:519. doi: 10.1186/s10194-015-0519-3.


Focal epilepsy presenting as a bath-induced paroxysmal event/breath-holding attack.

Stutchfield CJ, Loh NR.

Epilepsy Behav Case Rep. 2014 May 4;2:102-4. doi: 10.1016/j.ebcr.2014.03.005.


Erythromelalgia mutation Q875E Stabilizes the activated state of sodium channel Nav1.7.

Stadler T, O'Reilly AO, Lampert A.

J Biol Chem. 2015 Mar 6;290(10):6316-25. doi: 10.1074/jbc.M114.605899.


Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.

Gingras J, Smith S, Matson DJ, Johnson D, Nye K, Couture L, Feric E, Yin R, Moyer BD, Peterson ML, Rottman JB, Beiler RJ, Malmberg AB, McDonough SI.

PLoS One. 2014 Sep 4;9(9):e105895. doi: 10.1371/journal.pone.0105895.


Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation.

Eberhardt M, Nakajima J, Klinger AB, Neacsu C, Hühne K, O'Reilly AO, Kist AM, Lampe AK, Fischer K, Gibson J, Nau C, Winterpacht A, Lampert A.

J Biol Chem. 2014 Jan 24;289(4):1971-80. doi: 10.1074/jbc.M113.502211.


Infrequent SCN9A mutations in congenital insensitivity to pain and erythromelalgia.

Klein CJ, Wu Y, Kilfoyle DH, Sandroni P, Davis MD, Gavrilova RH, Low PA, Dyck PJ.

J Neurol Neurosurg Psychiatry. 2013 Apr;84(4):386-91. doi: 10.1136/jnnp-2012-303719.


Neurological perspectives on voltage-gated sodium channels.

Eijkelkamp N, Linley JE, Baker MD, Minett MS, Cregg R, Werdehausen R, Rugiero F, Wood JN.

Brain. 2012 Sep;135(Pt 9):2585-612. doi: 10.1093/brain/aws225. Review.


Extending the clinical spectrum of pain channelopathies.

Houlden H.

Brain. 2012 Feb;135(Pt 2):313-6. doi: 10.1093/brain/aws007. No abstract available.


Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7.

Estacion M, Han C, Choi JS, Hoeijmakers JG, Lauria G, Drenth JP, Gerrits MM, Dib-Hajj SD, Faber CG, Merkies IS, Waxman SG.

Mol Pain. 2011 Dec 2;7:92. doi: 10.1186/1744-8069-7-92.


Genetic basis of pain variability: recent advances.

Young EE, Lariviere WR, Belfer I.

J Med Genet. 2012 Jan;49(1):1-9. doi: 10.1136/jmedgenet-2011-100386. Review.

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