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Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant.

Li J, Vervoorts J, Carloni P, Rossetti G, Lüscher B.

BMC Bioinformatics. 2017 Jan 5;18(1):15. doi: 10.1186/s12859-016-1411-0.


Prospects for the Use of ATR Inhibitors to Treat Cancer.

Wagner JM, Kaufmann SH.

Pharmaceuticals (Basel). 2010 Apr 28;3(5):1311-1334. Review.


CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase.

Luo K, Deng M, Li Y, Wu C, Xu Z, Yuan J, Lou Z.

Nucleic Acids Res. 2015 Jun 23;43(11):5465-75. doi: 10.1093/nar/gkv434. Epub 2015 May 6.


ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53.

Linzen U, Lilischkis R, Pandithage R, Schilling B, Ullius A, Lüscher-Firzlaff J, Kremmer E, Lüscher B, Vervoorts J.

PLoS One. 2015 Apr 10;10(4):e0123736. doi: 10.1371/journal.pone.0123736. eCollection 2015 Apr 10.


Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase.

Luzwick JW, Nam EA, Zhao R, Cortez D.

PLoS One. 2014 Jun 5;9(6):e99397. doi: 10.1371/journal.pone.0099397. eCollection 2014 Jun 5.


Mammalian interphase cdks: dispensable master regulators of the cell cycle.

Enders GH.

Genes Cancer. 2012 Nov;3(11-12):614-8. doi: 10.1177/1947601913479799.


Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

Liu S, Ho CK, Ouyang J, Zou L.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2175-80. doi: 10.1073/pnas.1217781110. Epub 2013 Jan 23.


Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins.

Mohni KN, Dee AR, Smith S, Schumacher AJ, Weller SK.

J Virol. 2013 Jan;87(1):531-42. doi: 10.1128/JVI.02504-12. Epub 2012 Oct 24.


Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.

Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP.

PLoS Genet. 2012 Aug;8(8):e1002935. doi: 10.1371/journal.pgen.1002935. Epub 2012 Aug 23.


Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality.

Yashin AI, Wu D, Arbeev KG, Ukraintseva SV.

Rejuvenation Res. 2012 Aug;15(4):381-94. doi: 10.1089/rej.2011.1257. Epub 2012 Apr 25.


Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival.

Wilsker D, Chung JH, Pradilla I, Petermann E, Helleday T, Bunz F.

Mol Cancer Ther. 2012 Jan;11(1):98-107. doi: 10.1158/1535-7163.MCT-11-0675. Epub 2011 Nov 14.


DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.

Zhang W, Peng G, Lin SY, Zhang P.

J Biol Chem. 2011 Oct 14;286(41):35899-905. doi: 10.1074/jbc.M111.267690. Epub 2011 Aug 30.


Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

Johnson N, Li YC, Walton ZE, Cheng KA, Li D, Rodig SJ, Moreau LA, Unitt C, Bronson RT, Thomas HD, Newell DR, D'Andrea AD, Curtin NJ, Wong KK, Shapiro GI.

Nat Med. 2011 Jun 26;17(7):875-82. doi: 10.1038/nm.2377.


Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

Nam EA, Zhao R, Glick GG, Bansbach CE, Friedman DB, Cortez D.

J Biol Chem. 2011 Aug 19;286(33):28707-14. doi: 10.1074/jbc.M111.248914. Epub 2011 Jun 24.


ATR signalling: more than meeting at the fork.

Nam EA, Cortez D.

Biochem J. 2011 Jun 15;436(3):527-36. doi: 10.1042/BJ20102162. Review.


Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors.

Johnson N, Shapiro GI.

Expert Opin Ther Targets. 2010 Nov;14(11):1199-212. doi: 10.1517/14728222.2010.525221. Review.


Cdk2 is required for p53-independent G2/M checkpoint control.

Chung JH, Bunz F.

PLoS Genet. 2010 Feb 26;6(2):e1000863. doi: 10.1371/journal.pgen.1000863.


Overall Cdk activity modulates the DNA damage response in mammalian cells.

Cerqueira A, Santamaría D, Martínez-Pastor B, Cuadrado M, Fernández-Capetillo O, Barbacid M.

J Cell Biol. 2009 Dec 14;187(6):773-80. doi: 10.1083/jcb.200903033.


Functional genomic screens identify CINP as a genome maintenance protein.

Lovejoy CA, Xu X, Bansbach CE, Glick GG, Zhao R, Ye F, Sirbu BM, Titus LC, Shyr Y, Cortez D.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19304-9. doi: 10.1073/pnas.0909345106. Epub 2009 Nov 4.


Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage.

Wohlbold L, Fisher RP.

DNA Repair (Amst). 2009 Sep 2;8(9):1018-24. doi: 10.1016/j.dnarep.2009.04.009. Epub 2009 May 22. Review.

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