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Items: 1 to 20 of 1619


Using machine learning algorithms to identify genes essential for cell survival.

Philips S, Wu HY, Li L.

BMC Bioinformatics. 2017 Oct 3;18(Suppl 11):397. doi: 10.1186/s12859-017-1799-1.


Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis.

Zhou QM, Sun Y, Lu YY, Zhang H, Chen QL, Su SB.

Cancer Cell Int. 2017 Sep 26;17:84. doi: 10.1186/s12935-017-0453-3. eCollection 2017.


Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells.

Zhao M, Howard EW, Parris AB, Guo Z, Zhao Q, Ma Z, Xing Y, Liu B, Edgerton SM, Thor AD, Yang X.

Oncotarget. 2017 Jul 19;8(35):58847-58864. doi: 10.18632/oncotarget.19375. eCollection 2017 Aug 29.


The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2+/- mice through suppression of cell proliferation and induction of apoptosis.

Narov K, Yang J, Samsel P, Jones A, Sampson JR, Shen MH.

Oncotarget. 2017 Apr 19;8(35):58504-58512. doi: 10.18632/oncotarget.17215. eCollection 2017 Aug 29.


Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

Huang BX, Newcomer K, Kevala K, Barnaeva E, Zheng W, Hu X, Patnaik S, Southall N, Marugan J, Ferrer M, Kim HY.

Sci Rep. 2017 Sep 15;7(1):11673. doi: 10.1038/s41598-017-11870-1.


ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration.

Vo TTL, Park JH, Seo JH, Lee EJ, Choi H, Bae SJ, Le H, An S, Lee HS, Wee HJ, Kim KW.

Oncotarget. 2017 Jul 18;8(34):57216-57230. doi: 10.18632/oncotarget.19332. eCollection 2017 Aug 22.


Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle.

Renna LV, Bosè F, Iachettini S, Fossati B, Saraceno L, Milani V, Colombo R, Meola G, Cardani R.

PLoS One. 2017 Sep 15;12(9):e0184987. doi: 10.1371/journal.pone.0184987. eCollection 2017.


Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development.

Wang L, Ni Z, Liu Y, Ji S, Jin F, Jiang K, Ma J, Ren C, Zhang H, Hu Z, Zha X.

Oncotarget. 2017 Jul 4;8(33):54858-54872. doi: 10.18632/oncotarget.18963. eCollection 2017 Aug 15.


Single-Cell Phosphospecific Flow Cytometric Analysis of Canine and Murine Adipose-Derived Stem Cells.

Itoh H, Nishikawa S, Haraguchi T, Arikawa Y, Hiyama M, Iseri T, Itoh Y, Nakaichi M, Taura Y, Tani K, Itamoto K.

J Vet Med. 2017;2017:5701016. doi: 10.1155/2017/5701016. Epub 2017 Aug 16.


LEF1-AS1, a long-noncoding RNA, promotes malignancy in glioblastoma.

Wang J, Liu X, Yan C, Liu J, Wang S, Hong Y, Gu A, Zhao P.

Onco Targets Ther. 2017 Aug 28;10:4251-4260. doi: 10.2147/OTT.S130365. eCollection 2017.


Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN.

Cavazzoni A, La Monica S, Alfieri R, Ravelli A, Van Der Steen N, Sciarrillo R, Madeddu D, Lagrasta CAM, Quaini F, Bonelli M, Fumarola C, Cretella D, Digiacomo G, Tiseo M, Peters GJ, Ardizzoni A, Petronini PG, Giovannetti E.

Oncotarget. 2017 May 23;8(32):53068-53083. doi: 10.18632/oncotarget.18087. eCollection 2017 Aug 8.


Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways.

Zuo D, Sun F, Cui J, Liu Y, Liu Z, Zhou X, Li Z, Wu Y.

Sci Rep. 2017 Sep 5;7(1):10523. doi: 10.1038/s41598-017-10868-z.


New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway.

Alfieri R, Giovannetti E, Bonelli M, Cavazzoni A.

Front Oncol. 2017 Aug 9;7:170. doi: 10.3389/fonc.2017.00170. eCollection 2017. Review.


Reactive oxygen species extend insect life span using components of the insulin-signaling pathway.

Zhang XS, Wang T, Lin XW, Denlinger DL, Xu WH.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7832-E7840. doi: 10.1073/pnas.1711042114. Epub 2017 Aug 28.


The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders.

Yang JL, Chen WY, Chen SD.

Int J Mol Sci. 2017 Aug 26;18(9). pii: E1861. doi: 10.3390/ijms18091861. Review.


Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression.

Hung CY, Wang YC, Chuang JY, Young MJ, Liaw H, Chang WC, Hung JJ.

Sci Rep. 2017 Aug 22;7(1):9166. doi: 10.1038/s41598-017-09558-7.


Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis.

Peng F, Tang H, Liu P, Shen J, Guan X, Xie X, Gao J, Xiong L, Jia L, Chen J, Peng C.

Sci Rep. 2017 Aug 21;7(1):9022. doi: 10.1038/s41598-017-08422-y.


Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer.

Pedersen AK, Mendes Lopes de Melo J, Mørup N, Tritsaris K, Pedersen SF.

BMC Cancer. 2017 Aug 14;17(1):542. doi: 10.1186/s12885-017-3532-x.


XOR inhibition with febuxostat accelerates pulmonary endothelial barrier recovery and improves survival in lipopolysaccharide-induced murine sepsis.

Damarla M, Johnston LF, Liu G, Gao L, Wang L, Varela L, Kolb TM, Kim BS, Damico RL, Hassoun PM.

Physiol Rep. 2017 Aug;5(15). pii: e13377. doi: 10.14814/phy2.13377.


Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Kim SB, Dent R, Im SA, Espié M, Blau S, Tan AR, Isakoff SJ, Oliveira M, Saura C, Wongchenko MJ, Kapp AV, Chan WY, Singel SM, Maslyar DJ, Baselga J; LOTUS investigators.

Lancet Oncol. 2017 Oct;18(10):1360-1372. doi: 10.1016/S1470-2045(17)30450-3. Epub 2017 Aug 8.


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