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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E.

Cell Metab. 2017 Sep 5;26(3):547-557.e8. doi: 10.1016/j.cmet.2017.08.004.


Anti-aging drugs reduce hypothalamic inflammation in a sex-specific manner.

Sadagurski M, Cady G, Miller RA.

Aging Cell. 2017 Aug;16(4):652-660. doi: 10.1111/acel.12590. Epub 2017 May 20.


IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.

Ashpole NM, Logan S, Yabluchanskiy A, Mitschelen MC, Yan H, Farley JA, Hodges EL, Ungvari Z, Csiszar A, Chen S, Georgescu C, Hubbard GB, Ikeno Y, Sonntag WE.

Geroscience. 2017 Apr;39(2):129-145. doi: 10.1007/s11357-017-9971-0. Epub 2017 Apr 13.


Key proteins and pathways that regulate lifespan.

Pan H, Finkel T.

J Biol Chem. 2017 Apr 21;292(16):6452-6460. doi: 10.1074/jbc.R116.771915. Epub 2017 Mar 6. Review.


Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.

Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T.

Elife. 2016 Dec 19;5. pii: e20914. doi: 10.7554/eLife.20914.


In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state.

Aliper A, Belikov AV, Garazha A, Jellen L, Artemov A, Suntsova M, Ivanova A, Venkova L, Borisov N, Buzdin A, Mamoshina P, Putin E, Swick AG, Moskalev A, Zhavoronkov A.

Aging (Albany NY). 2016 Sep 24;8(9):2127-2152. doi: 10.18632/aging.101047.


Not Your Father's, or Mother's, Rodent: Moving Beyond B6.

Miller RA.

Neuron. 2016 Sep 21;91(6):1185-1186. doi: 10.1016/j.neuron.2016.09.009.


Sex Differences in Lifespan.

Austad SN, Fischer KE.

Cell Metab. 2016 Jun 14;23(6):1022-1033. doi: 10.1016/j.cmet.2016.05.019. Review.


Adaptations to chronic rapamycin in mice.

Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD.

Pathobiol Aging Age Relat Dis. 2016 May 27;6:31688. doi: 10.3402/pba.v6.31688. eCollection 2016.


The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.

Treuting PM, Snyder JM, Ikeno Y, Schofield PN, Ward JM, Sundberg JP.

Vet Pathol. 2016 Mar;53(2):244-9. doi: 10.1177/0300985815620629. Epub 2016 Jan 20.


Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans.

Chandler-Brown D, Choi H, Park S, Ocampo BR, Chen S, Le A, Sutphin GL, Shamieh LS, Smith ED, Kaeberlein M.

Front Genet. 2015 Oct 27;6:316. doi: 10.3389/fgene.2015.00316. eCollection 2015.


Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.

Thompson AC, Bruss MD, Price JC, Khambatta CF, Holmes WE, Colangelo M, Dalidd M, Roberts LS, Astle CM, Harrison DE, Hellerstein MK.

Aging Cell. 2016 Feb;15(1):118-27. doi: 10.1111/acel.12414. Epub 2015 Nov 6.


Biochemical Genetic Pathways that Modulate Aging in Multiple Species.

Bitto A, Wang AM, Bennett CF, Kaeberlein M.

Cold Spring Harb Perspect Med. 2015 Nov 2;5(11). pii: a025114. doi: 10.1101/cshperspect.a025114. Review.


The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

Ladiges W, Ikeno Y, Niedernhofer L, McIndoe RA, Ciol MA, Ritchey J, Liggitt D.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):431-4. doi: 10.1093/gerona/glv079. Epub 2015 Aug 4.


Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy.

Gnabre J, Bates R, Huang RC.

J Tradit Complement Med. 2015 Mar 12;5(3):119-26. doi: 10.1016/j.jtcme.2014.11.024. eCollection 2015 Jul. Review.


Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice.

Sadagurski M, Landeryou T, Cady G, Bartke A, Bernal-Mizrachi E, Miller RA.

Physiol Rep. 2015 Apr;3(4). pii: e12379. doi: 10.14814/phy2.12379.


Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age.

McAvoy K, Russo C, Kim S, Rankin G, Sahay A.

Hippocampus. 2015 Nov;25(11):1429-46. doi: 10.1002/hipo.22464. Epub 2015 May 2.


Effects of long-term exercise on spatial learning, memory ability, and cortical capillaries in aged rats.

Wang S, Chen L, Zhang L, Huang C, Xiu Y, Wang F, Zhou C, Luo Y, Xiao Q, Tang Y.

Med Sci Monit. 2015 Apr 1;21:945-54. doi: 10.12659/MSM.893935.


NIA's Intervention Testing Program at 10 years of age.

Warner HR.

Age (Dordr). 2015;37(2):22. doi: 10.1007/s11357-015-9761-5. Epub 2015 Mar 1.


Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span.

Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223. Epub 2014 Dec 22.

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