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The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.

Bagdas D, Wilkerson JL, Kulkarni A, Toma W, AlSharari S, Gul Z, Lichtman AH, Papke RL, Thakur GA, Damaj MI.

Br J Pharmacol. 2016 Aug;173(16):2506-20. doi: 10.1111/bph.13528. Epub 2016 Jul 18.


Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway.

Liu JS, Wei XD, Lu ZB, Xie P, Zhou HL, Chen YY, Ma JM, Yu LZ.

Oncotarget. 2016 Apr 19;7(16):21222-34. doi: 10.18632/oncotarget.8452.


The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response.

Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA.

Clin Transl Immunology. 2015 Dec 11;4(12):e53. doi: 10.1038/cti.2015.31. eCollection 2015 Dec.


Pulmonary inflammation is regulated by the levels of the vesicular acetylcholine transporter.

Pinheiro NM, Miranda CJ, Perini A, Câmara NO, Costa SK, Alonso-Vale MI, Caperuto LC, Tibério IF, Prado MA, Martins MA, Prado VF, Prado CM.

PLoS One. 2015 Mar 27;10(3):e0120441. doi: 10.1371/journal.pone.0120441. eCollection 2015.


The nicotinic receptor Alpha7 impacts the mouse lung response to LPS through multiple mechanisms.

Enioutina EY, Myers EJ, Tvrdik P, Hoidal JR, Rogers SW, Gahring LC.

PLoS One. 2015 Mar 24;10(3):e0121128. doi: 10.1371/journal.pone.0121128. eCollection 2015.


Using a non-invasive assessment of lung injury in a murine model of acute lung injury.

Lax S, Wilson MR, Takata M, Thickett DR.

BMJ Open Respir Res. 2014 Jan 3;1(1):e000014. doi: 10.1136/bmjresp-2013-000014. eCollection 2014.


Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.

Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H.

PLoS One. 2014 Aug 26;9(8):e105711. doi: 10.1371/journal.pone.0105711. eCollection 2014. Erratum in: PLoS One. 2016;11(3):e0152218.


Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals.

Wu H, Li L, Su X.

Biomed Res Int. 2014;2014:283525. doi: 10.1155/2014/283525. Epub 2014 Jul 20.


Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling.

Piegeler T, Dull RO, Hu G, Castellon M, Chignalia AZ, Koshy RG, Votta-Velis EG, Borgeat A, Schwartz DE, Beck-Schimmer B, Minshall RD.

BMC Anesthesiol. 2014 Jul 19;14:57. doi: 10.1186/1471-2253-14-57. eCollection 2014.


Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.

Gotts JE, Abbott J, Matthay MA.

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1;307(5):L395-406. doi: 10.1152/ajplung.00110.2014. Epub 2014 Jul 18.


Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in alternatively (M2)-activated macrophages.

Lee RH, Vazquez G.

Physiol Rep. 2013 Dec 26;1(7):e00189. doi: 10.1002/phy2.189. eCollection 2013 Dec 1.


Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21.

Hu Y, Liu R, Li J, Yue Y, Cheng W, Zhang P.

Biomed Res Int. 2014;2014:325875. doi: 10.1155/2014/325875. Epub 2014 Feb 27.


Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide.

Chen J, Mo Y, Schlueter CF, Hoyle GW.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):408-13. doi: 10.1016/j.taap.2013.06.009. Epub 2013 Jun 22.


Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction.

Berchtold CM, Coughlin A, Kasper Z, Thibeault SL.

Laryngoscope. 2013 Sep;123(9):2228-36. doi: 10.1002/lary.24052. Epub 2013 Mar 13.


Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells.

Takemura Y, Helms MN, Eaton AF, Self J, Ramosevac S, Jain L, Bao HF, Eaton DC.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15;304(6):L428-37. doi: 10.1152/ajplung.00129.2012. Epub 2013 Jan 4.


RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease.

Robinson AB, Stogsdill JA, Lewis JB, Wood TT, Reynolds PR.

Front Physiol. 2012 Jul 25;3:301. doi: 10.3389/fphys.2012.00301. eCollection 2012.


Acetylcholine and the alpha 7 nicotinic receptor: a potential therapeutic target for the treatment of periodontal disease?

Zoheir N, Lappin DF, Nile CJ.

Inflamm Res. 2012 Sep;61(9):915-26. doi: 10.1007/s00011-012-0513-z. Epub 2012 Jul 10. Review.


In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages.

Wongtrakool C, Grooms K, Ping XD, Rivera H, Ward J, Roser-Page S, Roman J, Brown LA, Gauthier TW.

Pediatr Res. 2012 Aug;72(2):147-53.


Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.

Lafargue M, Xu L, Carlès M, Serve E, Anjum N, Iles KE, Xiong X, Giffard R, Pittet JF.

FASEB J. 2012 Jul;26(7):2919-29. doi: 10.1096/fj.11-197384. Epub 2012 Apr 9.


Cholinergic regulation of airway inflammation and remodelling.

Kolahian S, Gosens R.

J Allergy (Cairo). 2012;2012:681258. doi: 10.1155/2012/681258. Epub 2012 Jan 16.

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