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Items: 8


The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease.

Wong SL, Sukkar MB.

Br J Pharmacol. 2017 Jan;174(1):3-14. doi: 10.1111/bph.13653. Epub 2016 Nov 25. Review.


Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.

Toba H, de Castro BrĂ¡s LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD.

Am J Physiol Cell Physiol. 2015 Jun 15;308(12):C972-82. doi: 10.1152/ajpcell.00402.2014. Epub 2015 Apr 15.


Secreted protein acidic and rich in cysteine (SPARC) exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis.

Ng YL, Klopcic B, Lloyd F, Forrest C, Greene W, Lawrance IC.

PLoS One. 2013 Oct 21;8(10):e77575. doi: 10.1371/journal.pone.0077575. eCollection 2013.


Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

Atorrasagasti C, Peixoto E, Aquino JB, Kippes N, Malvicini M, Alaniz L, Garcia M, Piccioni F, Fiore EJ, Bayo J, Bataller R, Guruceaga E, Corrales F, Podhajcer O, Mazzolini G.

PLoS One. 2013;8(2):e54962. doi: 10.1371/journal.pone.0054962. Epub 2013 Feb 11.


LPS induces greater bone and PDL loss in SPARC-null mice.

Trombetta-Esilva J, Yu H, Arias DN, Rossa C Jr, Kirkwood KL, Bradshaw AD.

J Dent Res. 2011 Apr;90(4):477-82. doi: 10.1177/0022034510391800. Epub 2010 Dec 29.


Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling.

Delany AM, Hankenson KD.

J Cell Commun Signal. 2009 Dec;3(3-4):227-38. doi: 10.1007/s12079-009-0076-0. Epub 2009 Oct 28.


Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC).

McCurdy S, Baicu CF, Heymans S, Bradshaw AD.

J Mol Cell Cardiol. 2010 Mar;48(3):544-9. doi: 10.1016/j.yjmcc.2009.06.018. Epub 2009 Jul 3. Review.


Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice.

Machado do Reis L, Kessler CB, Adams DJ, Lorenzo J, Jorgetti V, Delany AM.

Bone. 2008 Aug;43(2):264-73. doi: 10.1016/j.bone.2008.03.024. Epub 2008 Apr 13.

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