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Items: 1 to 20 of 26

1.

Clinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C.

Auranen M, Toppila J, Suriyanarayanan S, Lone MA, Paetau A, Tyynismaa H, Hornemann T, Ylikallio E.

Cold Spring Harb Mol Case Stud. 2017 Nov 21;3(6). pii: a002212. doi: 10.1101/mcs.a002212. Print 2017 Nov.

2.

Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.

Maekawa M, Lee M, Wei K, Ridgway ND, Fairn GD.

Sci Rep. 2016 Nov 2;6:35762. doi: 10.1038/srep35762.

3.

Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.

Sasset L, Zhang Y, Dunn TM, Di Lorenzo A.

Trends Endocrinol Metab. 2016 Nov;27(11):807-819. doi: 10.1016/j.tem.2016.07.005. Epub 2016 Aug 22. Review.

4.

Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.

Khan I, Katikaneni DS, Han Q, Sanchez-Felipe L, Hanada K, Ambrose RL, Mackenzie JM, Konan KV.

J Virol. 2014 Nov;88(21):12276-95. doi: 10.1128/JVI.00970-14. Epub 2014 Aug 13.

5.

The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations.

Beattie AE, Gupta SD, Frankova L, Kazlauskaite A, Harmon JM, Dunn TM, Campopiano DJ.

Biomed Res Int. 2013;2013:194371. doi: 10.1155/2013/194371. Epub 2013 Sep 23.

6.

Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis.

Chakraborty M, Lou C, Huan C, Kuo MS, Park TS, Cao G, Jiang XC.

J Clin Invest. 2013 Apr;123(4):1784-97. doi: 10.1172/JCI60415. Epub 2013 Mar 15. Erratum in: J Clin Invest. 2013 May;123(5):2332.

7.

Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.

Russo SB, Tidhar R, Futerman AH, Cowart LA.

J Biol Chem. 2013 May 10;288(19):13397-409. doi: 10.1074/jbc.M112.428185. Epub 2013 Mar 25.

8.

Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet.

Brozinick JT, Hawkins E, Hoang Bui H, Kuo MS, Tan B, Kievit P, Grove K.

Int J Obes (Lond). 2013 Aug;37(8):1064-70. doi: 10.1038/ijo.2012.191. Epub 2012 Dec 4.

9.

Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression.

Ruangsiriluk W, Grosskurth SE, Ziemek D, Kuhn M, des Etages SG, Francone OL.

J Lipid Res. 2012 Aug;53(8):1459-71. doi: 10.1194/jlr.M020941. Epub 2012 May 23.

10.
11.

Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction.

Lee SY, Kim JR, Hu Y, Khan R, Kim SJ, Bharadwaj KG, Davidson MM, Choi CS, Shin KO, Lee YM, Park WJ, Park IS, Jiang XC, Goldberg IJ, Park TS.

J Biol Chem. 2012 May 25;287(22):18429-39. doi: 10.1074/jbc.M111.296947. Epub 2012 Apr 9.

12.

Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.

Merrill AH Jr.

Chem Rev. 2011 Oct 12;111(10):6387-422. doi: 10.1021/cr2002917. Epub 2011 Sep 26. Review. No abstract available.

13.

The representation of protein complexes in the Protein Ontology (PRO).

Bult CJ, Drabkin HJ, Evsikov A, Natale D, Arighi C, Roberts N, Ruttenberg A, D'Eustachio P, Smith B, Blake JA, Wu C.

BMC Bioinformatics. 2011 Sep 19;12:371. doi: 10.1186/1471-2105-12-371.

14.

PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.

Bourquin F, Capitani G, Grütter MG.

Protein Sci. 2011 Sep;20(9):1492-508. doi: 10.1002/pro.679. Review.

15.

Membranes in balance: mechanisms of sphingolipid homeostasis.

Breslow DK, Weissman JS.

Mol Cell. 2010 Oct 22;40(2):267-79. doi: 10.1016/j.molcel.2010.10.005. Review.

16.

Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

Rotthier A, Auer-Grumbach M, Janssens K, Baets J, Penno A, Almeida-Souza L, Van Hoof K, Jacobs A, De Vriendt E, Schlotter-Weigel B, Löscher W, Vondráček P, Seeman P, De Jonghe P, Van Dijck P, Jordanova A, Hornemann T, Timmerman V.

Am J Hum Genet. 2010 Oct 8;87(4):513-22. doi: 10.1016/j.ajhg.2010.09.010.

17.

Deoxysphingoid bases as plasma markers in diabetes mellitus.

Bertea M, Rütti MF, Othman A, Marti-Jaun J, Hersberger M, von Eckardstein A, Hornemann T.

Lipids Health Dis. 2010 Aug 16;9:84. doi: 10.1186/1476-511X-9-84.

18.

Orm family proteins mediate sphingolipid homeostasis.

Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS.

Nature. 2010 Feb 25;463(7284):1048-53. doi: 10.1038/nature08787.

19.

The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.

Hornemann T, Penno A, Rütti MF, Ernst D, Kivrak-Pfiffner F, Rohrer L, von Eckardstein A.

J Biol Chem. 2009 Sep 25;284(39):26322-30. doi: 10.1074/jbc.M109.023192. Epub 2009 Aug 1.

20.

Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.

Tamehiro N, Mujawar Z, Zhou S, Zhuang DZ, Hornemann T, von Eckardstein A, Fitzgerald ML.

J Biol Chem. 2009 Sep 11;284(37):24881-90. doi: 10.1074/jbc.M109.014365. Epub 2009 Jul 10.

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