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LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis.

Janjanam J, Zhang B, Mani AM, Singh NK, Traylor JG Jr., Orr AW, Rao GN.

J Biol Chem. 2018 Mar 2;293(9):3088-3103. doi: 10.1074/jbc.RA117.000866. Epub 2018 Jan 11.


From structure to mechanism-understanding initiation of DNA replication.

Riera A, Barbon M, Noguchi Y, Reuter LM, Schneider S, Speck C.

Genes Dev. 2017 Jun 1;31(11):1073-1088. doi: 10.1101/gad.298232.117. Review.


Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.

Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H.

Nat Struct Mol Biol. 2017 Mar;24(3):316-324. doi: 10.1038/nsmb.3372. Epub 2017 Feb 13.


Structure of the active form of human origin recognition complex and its ATPase motor module.

Tocilj A, On KF, Yuan Z, Sun J, Elkayam E, Li H, Stillman B, Joshua-Tor L.

Elife. 2017 Jan 23;6. pii: e20818. doi: 10.7554/eLife.20818.


Mechanisms and regulation of DNA replication initiation in eukaryotes.

Parker MW, Botchan MR, Berger JM.

Crit Rev Biochem Mol Biol. 2017 Apr;52(2):107-144. doi: 10.1080/10409238.2016.1274717. Epub 2017 Jan 17. Review.


Chromosome Duplication in Saccharomyces cerevisiae.

Bell SP, Labib K.

Genetics. 2016 Jul;203(3):1027-67. doi: 10.1534/genetics.115.186452. Review.


Rapid Purification and Characterization of Mutant Origin Recognition Complexes in Saccharomyces cerevisiae.

Kawakami H, Ohashi E, Tsurimoto T, Katayama T.

Front Microbiol. 2016 Apr 18;7:521. doi: 10.3389/fmicb.2016.00521. eCollection 2016.


Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation.

Marques CA, Tiengwe C, Lemgruber L, Damasceno JD, Scott A, Paape D, Marcello L, McCulloch R.

Nucleic Acids Res. 2016 Jun 2;44(10):4763-84. doi: 10.1093/nar/gkw147. Epub 2016 Mar 6.


Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.

Búa S, Sotiropoulou P, Sgarlata C, Borlado LR, Eguren M, Domínguez O, Ortega S, Malumbres M, Blanpain C, Méndez J.

Cell Cycle. 2015;14(24):3897-907. doi: 10.1080/15384101.2015.1120919.


Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, Weinreich M.

Elife. 2015 Aug 25;4. doi: 10.7554/eLife.05795.


The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.

Duzdevich D, Warner MD, Ticau S, Ivica NA, Bell SP, Greene EC.

Mol Cell. 2015 May 7;58(3):483-94. doi: 10.1016/j.molcel.2015.03.017. Epub 2015 Apr 23.


Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.

Kunnev D, Freeland A, Qin M, Leach RW, Wang J, Shenoy RM, Pruitt SC.

Genome Res. 2015 Apr;25(4):558-69. doi: 10.1101/gr.176099.114. Epub 2015 Mar 11.


The role of lamin B1 for the maintenance of nuclear structure and function.

Camps J, Erdos MR, Ried T.

Nucleus. 2015;6(1):8-14. doi: 10.1080/19491034.2014.1003510. Review.


Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function.

Sun J, Fernandez-Cid A, Riera A, Tognetti S, Yuan Z, Stillman B, Speck C, Li H.

Genes Dev. 2014 Oct 15;28(20):2291-303. doi: 10.1101/gad.242313.114.


Geminin inhibits a late step in the formation of human pre-replicative complexes.

Wu M, Lu W, Santos RE, Frattini MG, Kelly TJ.

J Biol Chem. 2014 Oct 31;289(44):30810-21. doi: 10.1074/jbc.M114.552935. Epub 2014 Sep 17.


Multiple functions for Mcm2-7 ATPase motifs during replication initiation.

Kang S, Warner MD, Bell SP.

Mol Cell. 2014 Sep 4;55(5):655-65. doi: 10.1016/j.molcel.2014.06.033. Epub 2014 Jul 31.


A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA.

Samel SA, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C.

Genes Dev. 2014 Aug 1;28(15):1653-66. doi: 10.1101/gad.242404.114.


The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Evrin C, Fernández-Cid A, Riera A, Zech J, Clarke P, Herrera MC, Tognetti S, Lurz R, Speck C.

Nucleic Acids Res. 2014 Feb;42(4):2257-69. doi: 10.1093/nar/gkt1148. Epub 2013 Nov 14.


Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

Sun J, Evrin C, Samel SA, Fernández-Cid A, Riera A, Kawakami H, Stillman B, Speck C, Li H.

Nat Struct Mol Biol. 2013 Aug;20(8):944-51. doi: 10.1038/nsmb.2629. Epub 2013 Jul 14.


Activation of a human chromosomal replication origin by protein tethering.

Chen X, Liu G, Leffak M.

Nucleic Acids Res. 2013 Jul;41(13):6460-74. doi: 10.1093/nar/gkt368. Epub 2013 May 8.

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