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Items: 1 to 20 of 39

1.

Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors.

Waack U, Johnson TL, Chedid K, Xi C, Simmons LA, Mobley HLT, Sandkvist M.

Front Cell Infect Microbiol. 2017 Aug 28;7:380. doi: 10.3389/fcimb.2017.00380. eCollection 2017.

2.

3-Amino 1,8-naphthalimide, a structural analog of the anti-cholera drug virstatin inhibits chemically-biased swimming and swarming motility in vibrios.

Wang H, Silva AJ, Benitez JA.

Microbes Infect. 2017 Jun;19(6):370-375. doi: 10.1016/j.micinf.2017.03.003. Epub 2017 Apr 6.

PMID:
28392408
3.

A new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT.

Woodbrey AK, Onyango EO, Pellegrini M, Kovacikova G, Taylor RK, Gribble GW, Kull FJ.

Sci Rep. 2017 Mar 23;7:45011. doi: 10.1038/srep45011.

4.

Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators.

Mandal RS, Ta A, Sinha R, Theeya N, Ghosh A, Tasneem M, Bhunia A, Koley H, Das S.

Sci Rep. 2016 Dec 19;6:39454. doi: 10.1038/srep39454.

5.

Selective and Efficient Elimination of Vibrio cholerae with a Chemical Modulator that Targets Glucose Metabolism.

Oh YT, Kim HY, Kim EJ, Go J, Hwang W, Kim HR, Kim DW, Yoon SS.

Front Cell Infect Microbiol. 2016 Nov 16;6:156. eCollection 2016.

6.

Pseudomonas fluorescens Filamentous Hemagglutinin, an Iron-Regulated Protein, Is an Important Virulence Factor that Modulates Bacterial Pathogenicity.

Sun YY, Chi H, Sun L.

Front Microbiol. 2016 Aug 23;7:1320. doi: 10.3389/fmicb.2016.01320. eCollection 2016.

7.

1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae.

Li J, Wehmeyer G, Lovell S, Battaile KP, Egan SM.

Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):726-31. doi: 10.1107/S2053230X1601298X. Epub 2016 Aug 26.

8.

Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice.

Satitsri S, Pongkorpsakol P, Srimanote P, Chatsudthipong V, Muanprasat C.

Virulence. 2016 Oct 2;7(7):789-805. doi: 10.1080/21505594.2016.1192743. Epub 2016 May 24.

9.

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation.

Langdon A, Crook N, Dantas G.

Genome Med. 2016 Apr 13;8(1):39. doi: 10.1186/s13073-016-0294-z. Review.

10.

Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.

Hauser AR, Mecsas J, Moir DT.

Clin Infect Dis. 2016 Jul 1;63(1):89-95. doi: 10.1093/cid/ciw200. Epub 2016 Mar 29.

11.

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.

Good JA, Andersson C, Hansen S, Wall J, Krishnan KS, Begum A, Grundström C, Niemiec MS, Vaitkevicius K, Chorell E, Wittung-Stafshede P, Sauer UH, Sauer-Eriksson AE, Almqvist F, Johansson J.

Cell Chem Biol. 2016 Mar 17;23(3):404-14. doi: 10.1016/j.chembiol.2016.02.013.

12.

Narrow-spectrum inhibitors of Campylobacter jejuni flagellar expression and growth.

Johnson JG, Yuhas C, McQuade TJ, Larsen MJ, DiRita VJ.

Antimicrob Agents Chemother. 2015 Jul;59(7):3880-6. doi: 10.1128/AAC.04926-14. Epub 2015 Apr 13.

13.

Mechanism for inhibition of Vibrio cholerae ToxT activity by the unsaturated fatty acid components of bile.

Plecha SC, Withey JH.

J Bacteriol. 2015 May;197(10):1716-25. doi: 10.1128/JB.02409-14. Epub 2015 Mar 2.

14.

Glucose- but not rice-based oral rehydration therapy enhances the production of virulence determinants in the human pathogen Vibrio cholerae.

Kühn J, Finger F, Bertuzzo E, Borgeaud S, Gatto M, Rinaldo A, Blokesch M.

PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3347. doi: 10.1371/journal.pntd.0003347. eCollection 2014 Dec.

15.

A small unstructured region in Vibrio cholerae ToxT mediates the response to positive and negative effectors and ToxT proteolysis.

Thomson JJ, Plecha SC, Withey JH.

J Bacteriol. 2015 Feb;197(3):654-68. doi: 10.1128/JB.02068-14. Epub 2014 Nov 24.

16.

Chemical biology applied to the study of bacterial pathogens.

Anthouard R, DiRita VJ.

Infect Immun. 2015 Feb;83(2):456-69. doi: 10.1128/IAI.02021-14. Epub 2014 Nov 17. Review.

17.

Bicarbonate increases binding affinity of Vibrio cholerae ToxT to virulence gene promoters.

Thomson JJ, Withey JH.

J Bacteriol. 2014 Nov;196(22):3872-80. doi: 10.1128/JB.01824-14. Epub 2014 Sep 2.

18.

Virstatin inhibits biofilm formation and motility of Acinetobacter baumannii.

Nait Chabane Y, Mlouka MB, Alexandre S, Nicol M, Marti S, Pestel-Caron M, Vila J, Jouenne T, Dé E.

BMC Microbiol. 2014 Mar 12;14:62. doi: 10.1186/1471-2180-14-62.

19.

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

Yang J, Hocking DM, Cheng C, Dogovski C, Perugini MA, Holien JK, Parker MW, Hartland EL, Tauschek M, Robins-Browne RM.

J Biol Chem. 2013 Oct 25;288(43):31115-26. doi: 10.1074/jbc.M113.503912. Epub 2013 Sep 9.

20.

Small-molecule inhibitors of toxT expression in Vibrio cholerae.

Anthouard R, DiRita VJ.

MBio. 2013 Aug 6;4(4). pii: e00403-13. doi: 10.1128/mBio.00403-13.

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