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Items: 13


Structural Probing and Molecular Modeling of the A₃ Adenosine Receptor: A Focus on Agonist Binding.

Ciancetta A, Jacobson KA.

Molecules. 2017 Mar 11;22(3). pii: E449. doi: 10.3390/molecules22030449. Review.


New paradigms in GPCR drug discovery.

Jacobson KA.

Biochem Pharmacol. 2015 Dec 15;98(4):541-55. doi: 10.1016/j.bcp.2015.08.085. Epub 2015 Aug 8. Review.


Probing GPCR structure: adenosine and P2Y nucleotide receptors.

Jacobson KA, Costanzi S, Deflorian F.

Methods Enzymol. 2013;520:199-217. doi: 10.1016/B978-0-12-391861-1.00009-5.


Homology modeling of class a G protein-coupled receptors.

Costanzi S.

Methods Mol Biol. 2012;857:259-79. doi: 10.1007/978-1-61779-588-6_11.


Structure and activation of rhodopsin.

Zhou XE, Melcher K, Xu HE.

Acta Pharmacol Sin. 2012 Mar;33(3):291-9. doi: 10.1038/aps.2011.171. Epub 2012 Jan 23. Review.


Remote control of neuronal signaling.

Rogan SC, Roth BL.

Pharmacol Rev. 2011 Jun;63(2):291-315. doi: 10.1124/pr.110.003020. Epub 2011 Mar 17. Review.


2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.

Tosh DK, Chinn M, Yoo LS, Kang DW, Luecke H, Gao ZG, Jacobson KA.

Bioorg Med Chem. 2010 Jan 15;18(2):508-17. doi: 10.1016/j.bmc.2009.12.018. Epub 2009 Dec 11.


Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors.

Costanzi S, Siegel J, Tikhonova IG, Jacobson KA.

Curr Pharm Des. 2009;15(35):3994-4002. Review.


Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs).

Jacobson KA.

Bioconjug Chem. 2009 Oct 21;20(10):1816-35. doi: 10.1021/bc9000596. Epub 2009 Apr 30. Review.


Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models.

Li G, Haney KM, Kellogg GE, Zhang Y.

J Chem Inf Model. 2009 Jan;49(1):120-32. doi: 10.1021/ci800356a.


Engineering GPCR signaling pathways with RASSLs.

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL.

Nat Methods. 2008 Aug;5(8):673-8. doi: 10.1038/nmeth.1232. Review.


Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.

Palaniappan KK, Gao ZG, Ivanov AA, Greaves R, Adachi H, Besada P, Kim HO, Kim AY, Choe SA, Jeong LS, Jacobson KA.

Biochemistry. 2007 Jun 26;46(25):7437-48. Epub 2007 Jun 2.

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