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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.

Zhang T, Kwiatkowski N, Olson CM, Dixon-Clarke SE, Abraham BJ, Greifenberg AK, Ficarro SB, Elkins JM, Liang Y, Hannett NM, Manz T, Hao M, Bartkowiak B, Greenleaf AL, Marto JA, Geyer M, Bullock AN, Young RA, Gray NS.

Nat Chem Biol. 2016 Oct;12(10):876-84. doi: 10.1038/nchembio.2166.


CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment.

Even Y, Escande ML, Fayet C, Genevière AM.

PLoS One. 2016 Feb 17;11(2):e0149184. doi: 10.1371/journal.pone.0149184.


Cdk12 is essential for embryonic development and the maintenance of genomic stability.

Juan HC, Lin Y, Chen HR, Fann MJ.

Cell Death Differ. 2016 Jun;23(6):1038-48. doi: 10.1038/cdd.2015.157.


Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors.

Peyressatre M, Prével C, Pellerano M, Morris MC.

Cancers (Basel). 2015 Jan 23;7(1):179-237. doi: 10.3390/cancers7010179. Review.


Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration.

Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J.

Mol Cell Proteomics. 2014 Nov;13(11):2986-3000. doi: 10.1074/mcp.M113.036699.


An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

Echalier A, Hole AJ, Lolli G, Endicott JA, Noble ME.

ACS Chem Biol. 2014 Jun 20;9(6):1251-6. doi: 10.1021/cb500135f.


Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II.

Yogesha SD, Mayfield JE, Zhang Y.

Molecules. 2014 Jan 27;19(2):1481-511. doi: 10.3390/molecules19021481. Review.


Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.

Bakre A, Andersen LE, Meliopoulos V, Coleman K, Yan X, Brooks P, Crabtree J, Tompkins SM, Tripp RA.

PLoS One. 2013 Jun 21;8(6):e66796. doi: 10.1371/journal.pone.0066796.


Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer.

Mo W, Zhang J, Li X, Meng D, Gao Y, Yang S, Wan X, Zhou C, Guo F, Huang Y, Amente S, Avvedimento EV, Xie Y, Li Y.

PLoS One. 2013;8(2):e56592. doi: 10.1371/journal.pone.0056592.


CYCLIN-DEPENDENT KINASE G1 is associated with the spliceosome to regulate CALLOSE SYNTHASE5 splicing and pollen wall formation in Arabidopsis.

Huang XY, Niu J, Sun MX, Zhu J, Gao JF, Yang J, Zhou Q, Yang ZN.

Plant Cell. 2013 Feb;25(2):637-48. doi: 10.1105/tpc.112.107896.


Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.

Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB.

Mol Cell Biol. 2012 Nov;32(22):4691-704. doi: 10.1128/MCB.06267-11.


Updating the CTD Story: From Tail to Epic.

Bartkowiak B, Mackellar AL, Greenleaf AL.

Genet Res Int. 2011;2011:623718. doi: 10.4061/2011/623718.


Cyclin K goes with Cdk12 and Cdk13.

Kohoutek J, Blazek D.

Cell Div. 2012 Apr 18;7:12. doi: 10.1186/1747-1028-7-12.


The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM.

Genes Dev. 2011 Oct 15;25(20):2158-72. doi: 10.1101/gad.16962311.


Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.

Rohn JL, Sims D, Liu T, Fedorova M, Schöck F, Dopie J, Vartiainen MK, Kiger AA, Perrimon N, Baum B.

J Cell Biol. 2011 Sep 5;194(5):789-805. doi: 10.1083/jcb.201103168.


The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing.

Loyer P, Busson A, Trembley JH, Hyle J, Grenet J, Zhao W, Ribault C, Montier T, Kidd VJ, Lahti JM.

J Biol Chem. 2011 Jan 7;286(1):147-59. doi: 10.1074/jbc.M110.192518.


CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL.

Genes Dev. 2010 Oct 15;24(20):2303-16. doi: 10.1101/gad.1968210.


Cyclin-dependent kinases: a family portrait.

Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ.

Nat Cell Biol. 2009 Nov;11(11):1275-6. doi: 10.1038/ncb1109-1275. No abstract available.


TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization.

Tannukit S, Wen X, Wang H, Paine ML.

Int J Mol Sci. 2008 Aug;9(8):1504-14. doi: 10.3390/ijms9081504.

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