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Items: 1 to 20 of 24


HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.

Li A, Li J, Johnson KA.

J Biol Chem. 2016 Dec 16;291(51):26566-26585. Epub 2016 Oct 24.


Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.

Das K, Martinez SE, Bandwar RP, Arnold E.

Nucleic Acids Res. 2014 Jul;42(12):8125-37. doi: 10.1093/nar/gku487. Epub 2014 May 31.


Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition.

Auger A, Beilhartz GL, Zhu S, Cauchon E, Falgueyret JP, Grobler JA, Ehteshami M, Götte M, Melnyk RA.

J Biol Chem. 2011 Aug 26;286(34):29575-83. doi: 10.1074/jbc.M111.268235. Epub 2011 Jul 7.


A sequence-dependent exonuclease activity from Tetrahymena thermophila.

Tom HI, Greider CW.

BMC Biochem. 2010 Nov 16;11:45. doi: 10.1186/1471-2091-11-45.


Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific site.

Rigby ST, Van Nostrand KP, Rose AE, Gorelick RJ, Mathews DH, Bambara RA.

J Mol Biol. 2009 Dec 11;394(4):694-707. doi: 10.1016/j.jmb.2009.10.036. Epub 2009 Oct 21.


Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription.

Champoux JJ, Schultz SJ.

FEBS J. 2009 Mar;276(6):1506-16. doi: 10.1111/j.1742-4658.2009.06909.x. Epub 2009 Feb 18. Review.


Novel aptamer inhibitors of human immunodeficiency virus reverse transcriptase.

DeStefano JJ, Nair GR.

Oligonucleotides. 2008 Jun;18(2):133-44. doi: 10.1089/oli.2008.0103.


RNase H activity: structure, specificity, and function in reverse transcription.

Schultz SJ, Champoux JJ.

Virus Res. 2008 Jun;134(1-2):86-103. doi: 10.1016/j.virusres.2007.12.007. Epub 2008 Feb 7. Review.


Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template.

Küpfer PA, Crey-Desbiolles C, Leumann CJ.

Nucleic Acids Res. 2007;35(20):6846-53. Epub 2007 Oct 11.


In vitro synthesis of long DNA products in reactions with HIV-RT and nucleocapsid protein.

Anthony RM, Destefano JJ.

J Mol Biol. 2007 Jan 12;365(2):310-24. Epub 2006 Oct 6.


The role of template-primer in protection of reverse transcriptase from thermal inactivation.

Gerard GF, Potter RJ, Smith MD, Rosenthal K, Dhariwal G, Lee J, Chatterjee DK.

Nucleic Acids Res. 2002 Jul 15;30(14):3118-29.


Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H.

Wisniewski M, Balakrishnan M, Palaniappan C, Fay PJ, Bambara RA.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11978-83.


Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase.

DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA.

Nucleic Acids Res. 1993 Sep 11;21(18):4330-8.

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