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Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.

Wang X, Deng J, Yuan J, Tang X, Wang Y, Chen H, Liu Y, Zhou L.

Int J Oncol. 2017 Aug;51(2):467-477. doi: 10.3892/ijo.2017.4037. Epub 2017 Jun 8.


PTEN, Longevity and Age-Related Diseases.

Tait IS, Li Y, Lu J.

Biomedicines. 2013 Dec 13;1(1):17-48. doi: 10.3390/biomedicines1010017. Review.


Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.

Shao C, Li Z, Ahmad N, Liu X.

Cell Cycle. 2017 May 19;16(10):957-967. doi: 10.1080/15384101.2017.1310351. Epub 2017 Apr 24.


The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.

Weng M, Luo ZL, Wu XL, Zeng WZ.

Oncotarget. 2017 Mar 21;8(12):20288-20296. doi: 10.18632/oncotarget.15446.


Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.

Wang L, Zhu B, Wang S, Wu Y, Zhan W, Xie S, Shi H, Yu R.

Oncol Rep. 2017 May;37(5):2565-2574. doi: 10.3892/or.2017.5572. Epub 2017 Apr 11.


NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.

Feng S, Yang G, Yang H, Liang Z, Zhang R, Fan Y, Zhang G.

Cell Cycle. 2017 May 3;16(9):869-878. doi: 10.1080/15384101.2017.1308617. Epub 2017 Apr 5.


E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.

Xu Q, Zhu N, Chen S, Zhao P, Ren H, Zhu S, Tang H, Zhu Y, Qi Z.

Sci Rep. 2017 Mar 28;7:45375. doi: 10.1038/srep45375.


Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2.

Roy N, Pacini G, Berlioz-Torrent C, Janvier K.

J Cell Sci. 2017 May 1;130(9):1596-1611. doi: 10.1242/jcs.195412. Epub 2017 Mar 20.


H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.

Zhang X, Li B, Rezaeian AH, Xu X, Chou PC, Jin G, Han F, Pan BS, Wang CY, Long J, Zhang A, Huang CY, Tsai FJ, Tsai CH, Logothetis C, Lin HK.

Nat Commun. 2017 Mar 16;8:14799. doi: 10.1038/ncomms14799.


DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.

Wu R, Liu XM, Sun JG, Chen H, Ma J, Dong M, Peng S, Wang JQ, Ding JQ, Li DH, Speakman JR, Ning G, Jin W, Yuan Z.

Cell Discov. 2017 Feb 14;3:16054. doi: 10.1038/celldisc.2016.54. eCollection 2017.


The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.

Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC.

J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13.


Importin-11 keeps PTEN safe from harm.

Leslie NR.

J Cell Biol. 2017 Mar 6;216(3):539-541. doi: 10.1083/jcb.201612014. Epub 2017 Feb 13.


Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.

Zhang J, Li X, Zhang Y.

Mol Clin Oncol. 2017 Jan;6(1):96-100. doi: 10.3892/mco.2016.1092. Epub 2016 Nov 24.


The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy.

Sun A, Wei J, Childress C, Shaw JH 4th, Peng K, Shao G, Yang W, Lin Q.

Autophagy. 2017 Mar 4;13(3):522-537. doi: 10.1080/15548627.2016.1268301. Epub 2017 Jan 13.


Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells.

Li JJ, Wang R, Lama R, Wang X, Floyd ZE, Park EA, Liao FF.

Sci Rep. 2016 Dec 5;6:38550. doi: 10.1038/srep38550.


TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling.

Yin J, Kim TH, Park N, Shin D, Choi HI, Cho S, Park JB, Kim JH.

Oncotarget. 2016 Nov 29;7(48):79854-79868. doi: 10.18632/oncotarget.13036.


Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6.

Sun M, Cai J, Anderson RA, Sun Y.

J Biol Chem. 2016 Oct 7;291(41):21461-21473. Epub 2016 Aug 24.


Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease.

Canal M, Martín-Flores N, Pérez-Sisqués L, Romaní-Aumedes J, Altas B, Man HY, Kawabe H, Alberch J, Malagelada C.

Oncotarget. 2016 Sep 13;7(37):58813-58831. doi: 10.18632/oncotarget.11020.


PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis.

He J, Zhang Z, Ouyang M, Yang F, Hao H, Lamb KL, Yang J, Yin Y, Shen WH.

Nat Commun. 2016 Aug 5;7:12355. doi: 10.1038/ncomms12355.


Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer.

Bi H, Tian T, Zhu L, Zhou H, Hu H, Liu Y, Li X, Hu F, Zhao Y, Wang G.

Sci Rep. 2016 Jul 15;6:29869. doi: 10.1038/srep29869.

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