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Items: 17


Fragile sites in cancer: more than meets the eye.

Glover TW, Wilson TE, Arlt MF.

Nat Rev Cancer. 2017 Jul 25;17(8):489-501. doi: 10.1038/nrc.2017.52. Review.


DNA secondary structure at chromosomal fragile sites in human disease.

Thys RG, Lehman CE, Pierce LC, Wang YH.

Curr Genomics. 2015 Feb;16(1):60-70. doi: 10.2174/1389202916666150114223205.


In vitro and in vivo effects of graphene oxide and reduced graphene oxide on glioblastoma.

Jaworski S, Sawosz E, Kutwin M, Wierzbicki M, Hinzmann M, Grodzik M, Winnicka A, Lipińska L, Włodyga K, Chwalibog A.

Int J Nanomedicine. 2015 Feb 25;10:1585-96. doi: 10.2147/IJN.S77591. eCollection 2015.


Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?

Georgakilas AG, Tsantoulis P, Kotsinas A, Michalopoulos I, Townsend P, Gorgoulis VG.

Cell Mol Life Sci. 2014 Dec;71(23):4519-44. doi: 10.1007/s00018-014-1717-x. Epub 2014 Sep 20. Review.


Genome instability at common fragile sites: searching for the cause of their instability.

Franchitto A.

Biomed Res Int. 2013;2013:730714. doi: 10.1155/2013/730714. Epub 2013 Sep 5. Review.


Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.

Lyndaker AM, Lim PX, Mleczko JM, Diggins CE, Holloway JK, Holmes RJ, Kan R, Schlafer DH, Freire R, Cohen PE, Weiss RS.

PLoS Genet. 2013;9(2):e1003320. doi: 10.1371/journal.pgen.1003320. Epub 2013 Feb 28.


In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells.

Jaworski S, Sawosz E, Grodzik M, Winnicka A, Prasek M, Wierzbicki M, Chwalibog A.

Int J Nanomedicine. 2013;8:413-20. doi: 10.2147/IJN.S39456. Epub 2013 Jan 24.


Common fragile sites: genomic hotspots of DNA damage and carcinogenesis.

Ma K, Qiu L, Mrasek K, Zhang J, Liehr T, Quintana LG, Li Z.

Int J Mol Sci. 2012;13(9):11974-99. doi: 10.3390/ijms130911974. Epub 2012 Sep 20. Review.


Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR, Lee J, Riccio ML, Reeves AP, Sutter NB, Noden DM, Peters RM, Weiss RS.

Hum Mol Genet. 2012 Aug 1;21(15):3408-20. doi: 10.1093/hmg/dds173. Epub 2012 May 9.


The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling.

Pichierri P, Nicolai S, Cignolo L, Bignami M, Franchitto A.

Oncogene. 2012 Jun 7;31(23):2809-23. doi: 10.1038/onc.2011.468. Epub 2011 Oct 17.


DNA instability at chromosomal fragile sites in cancer.

Dillon LW, Burrow AA, Wang YH.

Curr Genomics. 2010 Aug;11(5):326-37. doi: 10.2174/138920210791616699.


UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

Tien AL, Senbanerjee S, Kulkarni A, Mudbhary R, Goudreau B, Ganesan S, Sadler KC, Ukomadu C.

Biochem J. 2011 Apr 1;435(1):175-85. doi: 10.1042/BJ20100840.


Removing all obstacles: a critical role for p53 in promoting tissue renewal.

Schoppy DW, Ruzankina Y, Brown EJ.

Cell Cycle. 2010 Apr 1;9(7):1313-9. Epub 2010 Apr 1. Review.


ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.

Wan C, Kulkarni A, Wang YH.

Mutat Res. 2010 Apr 1;686(1-2):39-46. doi: 10.1016/j.mrfmmm.2009.12.012. Epub 2010 Jan 7.


Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.

Yazinski SA, Westcott PM, Ong K, Pinkas J, Peters RM, Weiss RS.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21282-7. doi: 10.1073/pnas.0904965106. Epub 2009 Nov 16.


Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.

Smith KD, Fu MA, Brown EJ.

J Cell Biol. 2009 Oct 5;187(1):15-23. doi: 10.1083/jcb.200905006.


ATR and H2AX cooperate in maintaining genome stability under replication stress.

Chanoux RA, Yin B, Urtishak KA, Asare A, Bassing CH, Brown EJ.

J Biol Chem. 2009 Feb 27;284(9):5994-6003. doi: 10.1074/jbc.M806739200. Epub 2008 Dec 2.

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