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Items: 1 to 20 of 29

1.

Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells.

Dong L, Krewson EA, Yang LV.

Int J Mol Sci. 2017 Jan 27;18(2). pii: E278. doi: 10.3390/ijms18020278.

2.

GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis.

Sanderlin EJ, Leffler NR, Lertpiriyapong K, Cai Q, Hong H, Bakthavatchalu V, Fox JG, Oswald JZ, Justus CR, Krewson EA, O'Rourke D, Yang LV.

Biochim Biophys Acta. 2017 Feb;1863(2):569-584. doi: 10.1016/j.bbadis.2016.12.005.

PMID:
27940273
3.

Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO.

Sun X, Tommasi E, Molina D, Sah R, Brosnihan KB, Diz D, Petrovic S.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1260-F1266. doi: 10.1152/ajprenal.00410.2016.

PMID:
27681561
4.

The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer.

Jing Z, Xu H, Chen X, Zhong Q, Huang J, Zhang Y, Guo W, Yang Z, Ding S, Chen P, Huang Z.

PLoS One. 2016 Apr 14;11(4):e0152789. doi: 10.1371/journal.pone.0152789.

5.

PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.

Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA.

Science. 2015 Jun 12;348(6240):1255-60. doi: 10.1126/science.aaa0922.

6.

Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment.

Justus CR, Sanderlin EJ, Yang LV.

Int J Mol Sci. 2015 May 15;16(5):11055-86. doi: 10.3390/ijms160511055. Review.

7.

Ischemia/reperfusion-induced CHOP expression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4.

Dong B, Zhou H, Han C, Yao J, Xu L, Zhang M, Fu Y, Xia Q.

PLoS One. 2014 Oct 24;9(10):e110944. doi: 10.1371/journal.pone.0110944.

8.

GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling.

Cui H, Wang Y, Huang H, Yu W, Bai M, Zhang L, Bryan BA, Wang Y, Luo J, Li D, Ma Y, Liu M.

J Biol Chem. 2014 Dec 12;289(50):34871-85. doi: 10.1074/jbc.M114.571000.

9.

Ionotropic and metabotropic proton-sensing receptors involved in airway inflammation in allergic asthma.

Aoki H, Mogi C, Okajima F.

Mediators Inflamm. 2014;2014:712962. doi: 10.1155/2014/712962. Review.

10.

RNAi targeting GPR4 influences HMEC-1 gene expression by microarray analysis.

Ren J, Zhang Y, Cai H, Ma H, Zhao D, Zhang X, Li Z, Wang S, Wang J, Liu R, Li Y, Qian J, Wei H, Niu L, Liu Y, Xiao L, Ding M, Jiang S.

Int J Clin Exp Med. 2014 Mar 15;7(3):607-15.

11.

Autophagic clearance of mitochondria in the kidney copes with metabolic acidosis.

Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Matsuda J, Kitamura H, Niimura F, Matsusaka T, Iwatani H, Matsui I, Kaimori J, Kioka H, Isaka Y, Rakugi H.

J Am Soc Nephrol. 2014 Oct;25(10):2254-66. doi: 10.1681/ASN.2013090986.

12.

The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators..

Br J Pharmacol. 2013 Dec;170(8):1459-581. doi: 10.1111/bph.12445.

13.

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors.

Justus CR, Dong L, Yang LV.

Front Physiol. 2013 Dec 5;4:354. doi: 10.3389/fphys.2013.00354. Review.

14.

Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8.

Li Z, Dong L, Dean E, Yang LV.

Int J Mol Sci. 2013 Oct 11;14(10):20236-55. doi: 10.3390/ijms141020236.

15.

Chemokine receptor-like 2 is involved in ischemic brain injury.

Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell FL Jr, Haddad GG, Yao H.

J Exp Stroke Transl Med. 2013 Feb 17;6:1-6.

16.

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ.

Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. Review.

17.

Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Gα12/13-Rho-Rac1 pathway.

Li J, Guo B, Wang J, Cheng X, Xu Y, Sang J.

J Mol Signal. 2013 May 10;8(1):6. doi: 10.1186/1750-2187-8-6.

18.

Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis.

Dong L, Li Z, Leffler NR, Asch AS, Chi JT, Yang LV.

PLoS One. 2013 Apr 16;8(4):e61991. doi: 10.1371/journal.pone.0061991.

19.

Molecular mechanisms of acid-base sensing by the kidney.

Brown D, Wagner CA.

J Am Soc Nephrol. 2012 May;23(5):774-80. doi: 10.1681/ASN.2012010029. Review.

20.

Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.

Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang LV.

PLoS One. 2011;6(11):e27586. doi: 10.1371/journal.pone.0027586.

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