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Items: 1 to 20 of 59

1.

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

Kratter IH, Zahed H, Lau A, Tsvetkov AS, Daub AC, Weiberth KF, Gu X, Saudou F, Humbert S, Yang XW, Osmand A, Steffan JS, Masliah E, Finkbeiner S.

J Clin Invest. 2016 Sep 1;126(9):3585-97. doi: 10.1172/JCI80339. Epub 2016 Aug 15.

2.

Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.

Chaibva M, Jawahery S, Pilkington AW 4th, Arndt JR, Sarver O, Valentine S, Matysiak S, Legleiter J.

Biophys J. 2016 Jul 26;111(2):349-62. doi: 10.1016/j.bpj.2016.06.018.

PMID:
27463137
3.

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Yin X, Manczak M, Reddy PH.

Hum Mol Genet. 2016 May 1;25(9):1739-53. doi: 10.1093/hmg/ddw045. Epub 2016 Feb 16.

PMID:
26908605
4.
5.

Studying polyglutamine diseases in Drosophila.

Xu Z, Tito AJ, Rui YN, Zhang S.

Exp Neurol. 2015 Dec;274(Pt A):25-41. doi: 10.1016/j.expneurol.2015.08.002. Epub 2015 Aug 6. Review.

6.

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

El-Daher MT, Hangen E, Bruyère J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, Lévêque-Fort S, Botas J, Humbert S, Saudou F.

EMBO J. 2015 Sep 2;34(17):2255-71. doi: 10.15252/embj.201490808. Epub 2015 Jul 12.

7.

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin.

Huang B, Lucas T, Kueppers C, Dong X, Krause M, Bepperling A, Buchner J, Voshol H, Weiss A, Gerrits B, Kochanek S.

PLoS One. 2015 Mar 23;10(3):e0121055. doi: 10.1371/journal.pone.0121055. eCollection 2015.

8.

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.

Arndt JR, Chaibva M, Legleiter J.

Biomol Concepts. 2015 Mar;6(1):33-46. doi: 10.1515/bmc-2015-0001. Review.

9.

Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane.

Brandstaetter H, Kruppa AJ, Buss F.

Dis Model Mech. 2014 Dec;7(12):1335-40. doi: 10.1242/dmm.017368. Epub 2014 Oct 31.

10.

Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease.

Francelle L, Galvan L, Brouillet E.

Front Cell Neurosci. 2014 Sep 26;8:295. doi: 10.3389/fncel.2014.00295. eCollection 2014. Review.

11.

BDNF signaling and survival of striatal neurons.

Baydyuk M, Xu B.

Front Cell Neurosci. 2014 Aug 28;8:254. doi: 10.3389/fncel.2014.00254. eCollection 2014. Review.

12.

Transgenic rat model of Huntington's disease: a histopathological study and correlations with neurodegenerative process in the brain of HD patients.

Mazurová Y, Anderova M, Němečková I, Bezrouk A.

Biomed Res Int. 2014;2014:291531. doi: 10.1155/2014/291531. Epub 2014 Aug 3.

13.

Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.

Watkin EE, Arbez N, Waldron-Roby E, O'Meally R, Ratovitski T, Cole RN, Ross CA.

PLoS One. 2014 Feb 5;9(2):e88284. doi: 10.1371/journal.pone.0088284. eCollection 2014.

14.

A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.

Tourette C, Li B, Bell R, O'Hare S, Kaltenbach LS, Mooney SD, Hughes RE.

J Biol Chem. 2014 Mar 7;289(10):6709-26. doi: 10.1074/jbc.M113.523696. Epub 2014 Jan 9.

15.

Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.

Xu Q, Huang S, Song M, Wang CE, Yan S, Liu X, Gaertig MA, Yu SP, Li H, Li S, Li XJ.

J Cell Biol. 2013 Sep 30;202(7):1123-38. doi: 10.1083/jcb.201303146.

16.

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.

Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Déglon N, Beal MF, Brouillet E.

Hum Mol Genet. 2013 Oct 1;22(19):3869-82. doi: 10.1093/hmg/ddt242. Epub 2013 May 29.

17.

Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.

Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S, Li XJ.

J Neurosci. 2013 May 8;33(19):8172-84. doi: 10.1523/JNEUROSCI.0119-13.2013.

18.

Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model.

Aidt FH, Nielsen SM, Kanters J, Pesta D, Nielsen TT, Nørremølle A, Hasholt L, Christiansen M, Hagen CM.

PLoS Curr. 2013 Apr 2;5. pii: ecurrents.hd.d8917b4862929772c5a2f2a34ef1c201. doi: 10.1371/currents.hd.d8917b4862929772c5a2f2a34ef1c201.

19.

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster.

Zala D, Hinckelmann MV, Saudou F.

PLoS One. 2013;8(3):e60162. doi: 10.1371/journal.pone.0060162. Epub 2013 Mar 28.

20.

Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease.

Sarantos MR, Papanikolaou T, Ellerby LM, Hughes RE.

J Huntingtons Dis. 2012;1(2):195-210. doi: 10.3233/JHD-120033.

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