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Items: 9


Continual renewal and replication of persistent Leishmania major parasites in concomitantly immune hosts.

Mandell MA, Beverley SM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E801-E810. doi: 10.1073/pnas.1619265114. Epub 2017 Jan 17.


The maize brown midrib2 (bm2) gene encodes a methylenetetrahydrofolate reductase that contributes to lignin accumulation.

Tang HM, Liu S, Hill-Skinner S, Wu W, Reed D, Yeh CT, Nettleton D, Schnable PS.

Plant J. 2014 Feb;77(3):380-92. doi: 10.1111/tpj.12394. Epub 2014 Jan 10.


The MET13 methylenetetrahydrofolate reductase gene is essential for infection-related morphogenesis in the rice blast fungus Magnaporthe oryzae.

Yan X, Que Y, Wang H, Wang C, Li Y, Yue X, Ma Z, Talbot NJ, Wang Z.

PLoS One. 2013 Oct 7;8(10):e76914. doi: 10.1371/journal.pone.0076914. eCollection 2013.


Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages.

Sansom FM, Tang L, Ralton JE, Saunders EC, Naderer T, McConville MJ.

PLoS One. 2013;8(2):e56064. doi: 10.1371/journal.pone.0056064. Epub 2013 Feb 20.


Folate metabolic pathways in Leishmania.

Vickers TJ, Beverley SM.

Essays Biochem. 2011;51:63-80. doi: 10.1042/bse0510063. Review.


Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major.

Ong HB, Sienkiewicz N, Wyllie S, Fairlamb AH.

J Biol Chem. 2011 Mar 25;286(12):10429-38. doi: 10.1074/jbc.M110.209593. Epub 2011 Jan 14.


Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity.

Madeira da Silva L, Beverley SM.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11965-70. doi: 10.1073/pnas.1004599107. Epub 2010 Jun 15.


Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli.

Lee MN, Takawira D, Nikolova AP, Ballou DP, Furtado VC, Phung NL, Still BR, Thorstad MK, Tanner JJ, Trimmer EE.

Biochemistry. 2009 Aug 18;48(32):7673-85. doi: 10.1021/bi9007325.


Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.

Murta SM, Vickers TJ, Scott DA, Beverley SM.

Mol Microbiol. 2009 Mar;71(6):1386-401. doi: 10.1111/j.1365-2958.2009.06610.x. Epub 2009 Jan 16.

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