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Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion.

Simões T, Schuster R, den Brave F, Escobar-Henriques M.

Elife. 2018 Jan 8;7. pii: e30015. doi: 10.7554/eLife.30015.


Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells.

Hwang S, Gustafsson HT, O'Sullivan C, Bisceglia G, Huang X, Klose C, Schevchenko A, Dickson RC, Cavaliere P, Dephoure N, Torres EM.

Cell Rep. 2017 Dec 26;21(13):3807-3818. doi: 10.1016/j.celrep.2017.11.103.


Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein.

D'Alessandro M, Beesley S, Kim JK, Jones Z, Chen R, Wi J, Kyle K, Vera D, Pagano M, Nowakowski R, Lee C.

Curr Biol. 2017 Nov 20;27(22):3454-3467.e8. doi: 10.1016/j.cub.2017.10.014. Epub 2017 Nov 2.


Impairment of protein degradation and proteasome function in hereditary neuropathies.

VerPlank JJS, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L.

Glia. 2018 Feb;66(2):379-395. doi: 10.1002/glia.23251. Epub 2017 Oct 27.


Meddling with Fate: The Proteasomal Deubiquitinating Enzymes.

de Poot SAH, Tian G, Finley D.

J Mol Biol. 2017 Nov 10;429(22):3525-3545. doi: 10.1016/j.jmb.2017.09.015. Epub 2017 Oct 5. Review.


An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.

Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D.

J Biol Chem. 2017 Nov 24;292(47):19209-19225. doi: 10.1074/jbc.M117.815126. Epub 2017 Sep 26.


Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast.

Gu ZC, Wu E, Sailer C, Jando J, Styles E, Eisenkolb I, Kuschel M, Bitschar K, Wang X, Huang L, Vissa A, Yip CM, Yedidi RS, Friesen H, Enenkel C.

Mol Biol Cell. 2017 Sep 15;28(19):2479-2491. doi: 10.1091/mbc.E17-03-0162. Epub 2017 Aug 2.


The Logic of the 26S Proteasome.

Collins GA, Goldberg AL.

Cell. 2017 May 18;169(5):792-806. doi: 10.1016/j.cell.2017.04.023. Review.


The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis.

Kim HT, Goldberg AL.

J Biol Chem. 2017 Jun 9;292(23):9830-9839. doi: 10.1074/jbc.M116.763128. Epub 2017 Apr 17.


Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.

Kuo CL, Goldberg AL.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3404-E3413. doi: 10.1073/pnas.1701734114. Epub 2017 Apr 10.


The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease.

Nath SR, Lieberman AP.

Front Mol Neurosci. 2017 Mar 22;10:78. doi: 10.3389/fnmol.2017.00078. eCollection 2017. Review.


Phospholipase Lpl1 links lipid droplet function with quality control protein degradation.

Weisshaar N, Welsch H, Guerra-Moreno A, Hanna J.

Mol Biol Cell. 2017 Mar 15;28(6):716-725. doi: 10.1091/mbc.E16-10-0717. Epub 2017 Jan 18.


The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance.

Dodgson SE, Santaguida S, Kim S, Sheltzer J, Amon A.

Genes Dev. 2016 Oct 15;30(20):2259-2271. Epub 2016 Nov 2.


Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress.

Fang NN, Zhu M, Rose A, Wu KP, Mayor T.

Nat Commun. 2016 Oct 4;7:12907. doi: 10.1038/ncomms12907.


The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death.

Livneh I, Cohen-Kaplan V, Cohen-Rosenzweig C, Avni N, Ciechanover A.

Cell Res. 2016 Aug;26(8):869-85. doi: 10.1038/cr.2016.86. Epub 2016 Jul 22. Review.


Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.

Chen X, Randles L, Shi K, Tarasov SG, Aihara H, Walters KJ.

Structure. 2016 Aug 2;24(8):1257-1270. doi: 10.1016/j.str.2016.05.018. Epub 2016 Jul 7.


Trial Watch: Proteasomal inhibitors for anticancer therapy.

Obrist F, Manic G, Kroemer G, Vitale I, Galluzzi L.

Mol Cell Oncol. 2014 Dec 1;2(2):e974463. doi: 10.4161/23723556.2014.974463. eCollection 2015 Apr-Jun. Review.


An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substrates.

Bhattacharyya S, Renn JP, Yu H, Marko JF, Matouschek A.

Anal Biochem. 2016 Sep 15;509:50-59. doi: 10.1016/j.ab.2016.05.026. Epub 2016 Jun 11.


Ubiquitin-like domains can target to the proteasome but proteolysis requires a disordered region.

Yu H, Kago G, Yellman CM, Matouschek A.

EMBO J. 2016 Jul 15;35(14):1522-36. doi: 10.15252/embj.201593147. Epub 2016 May 27.


Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.

Yu C, Yang Y, Wang X, Guan S, Fang L, Liu F, Walters KJ, Kaiser P, Huang L.

Mol Cell Proteomics. 2016 Jul;15(7):2279-92. doi: 10.1074/mcp.M116.058271. Epub 2016 Apr 25.

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