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Items: 1 to 20 of 32


Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.

Notario-PĂ©rez F, Ruiz-Caro R, Veiga-Ochoa MD.

Drug Des Devel Ther. 2017 Jun 15;11:1767-1787. doi: 10.2147/DDDT.S133170. eCollection 2017. Review.


The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans.

Hopper JTS, Ambrose S, Grant OC, Krumm SA, Allison TM, Degiacomi MT, Tully MD, Pritchard LK, Ozorowski G, Ward AB, Crispin M, Doores KJ, Woods RJ, Benesch JLP, Robinson CV, Struwe WB.

Structure. 2017 May 2;25(5):773-782.e5. doi: 10.1016/j.str.2017.03.015. Epub 2017 Apr 20.


Non-Antiretroviral Microbicides for HIV Prevention.

Scott Y, Dezzutti CS.

AIDS Rev. 2016 Jul-Sep;18(3):145-150.


Expression of Human Immunodeficiency Virus Type 1 Neutralizing Antibody Fragments Using Human Vaginal Lactobacillus.

Marcobal A, Liu X, Zhang W, Dimitrov AS, Jia L, Lee PP, Fouts TR, Parks TP, Lagenaur LA.

AIDS Res Hum Retroviruses. 2016 Oct/Nov;32(10-11):964-971. Epub 2016 Apr 13.


Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing.

Madeira LM, Szeto TH, Ma JK, Drake PMW.

Biotechnol J. 2016 Jul;11(7):910-919. doi: 10.1002/biot.201500371. Epub 2016 Mar 9.


Robust vaginal colonization of macaques with a novel vaginally disintegrating tablet containing a live biotherapeutic product to prevent HIV infection in women.

Lagenaur LA, Swedek I, Lee PP, Parks TP.

PLoS One. 2015 Apr 14;10(4):e0122730. doi: 10.1371/journal.pone.0122730. eCollection 2015.


Escherichia coli surface display of single-chain antibody VRC01 against HIV-1 infection.

Wang LX, Mellon M, Bowder D, Quinn M, Shea D, Wood C, Xiang SH.

Virology. 2015 Jan 15;475:179-86. doi: 10.1016/j.virol.2014.11.018. Epub 2014 Dec 5.


Antiviral lectins as potential HIV microbicides.

Koharudin LM, Gronenborn AM.

Curr Opin Virol. 2014 Aug;7:95-100. doi: 10.1016/j.coviro.2014.05.006. Epub 2014 Jul 8. Review.


In vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model.

Brichacek B, Lagenaur LA, Lee PP, Venzon D, Hamer DH.

PLoS One. 2013 Nov 12;8(11):e78817. doi: 10.1371/journal.pone.0078817. eCollection 2013.


Development of an HIV-1 Microbicide Based on Caulobacter crescentus: Blocking Infection by High-Density Display of Virus Entry Inhibitors.

Farr C, Nomellini JF, Ailon E, Shanina I, Sangsari S, Cavacini LA, Smit J, Horwitz MS.

PLoS One. 2013 Jun 19;8(6):e65965. doi: 10.1371/journal.pone.0065965. Print 2013.


Mucosal Lactobacillus vectored vaccines.

Yu Q, Zhu L, Kang H, Yang Q.

Hum Vaccin Immunother. 2013 Apr;9(4):805-7. doi: 10.4161/hv.23302. Epub 2013 Jan 15. Review.


Homeostatic properties of Lactobacillus jensenii engineered as a live vaginal anti-HIV microbicide.

Yamamoto HS, Xu Q, Fichorova RN.

BMC Microbiol. 2013 Jan 8;13:4. doi: 10.1186/1471-2180-13-4.


Commensal bacteria modulate innate immune responses of vaginal epithelial cell multilayer cultures.

Rose WA 2nd, McGowin CL, Spagnuolo RA, Eaves-Pyles TD, Popov VL, Pyles RB.

PLoS One. 2012;7(3):e32728. doi: 10.1371/journal.pone.0032728. Epub 2012 Mar 7.


Microbicides: a new hope for HIV prevention.

Nutan, Gupta SK.

Indian J Med Res. 2011 Dec;134(6):939-49. doi: 10.4103/0971-5916.92639. Review.


The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells.

Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.

Virology. 2012 Feb 20;423(2):175-86. doi: 10.1016/j.virol.2011.12.001. Epub 2011 Dec 29.


Advances in HIV microbicide development.

Olsen JS, Easterhoff D, Dewhurst S.

Future Med Chem. 2011 Dec;3(16):2101-16. doi: 10.4155/fmc.11.153. Review.


Demonstration of vaginal colonization with GusA-expressing Lactobacillus jensenii following oral delivery in rhesus macaques.

Lagenaur LA, Lee PP, Hamer DH, Sanders-Beer BE.

Res Microbiol. 2011 Dec;162(10):1006-10. doi: 10.1016/j.resmic.2011.08.003. Epub 2011 Aug 29.


Designed oligomers of cyanovirin-N show enhanced HIV neutralization.

Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14079-84. doi: 10.1073/pnas.1108777108. Epub 2011 Jul 28.


Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus.

Lagenaur LA, Sanders-Beer BE, Brichacek B, Pal R, Liu X, Liu Y, Yu R, Venzon D, Lee PP, Hamer DH.

Mucosal Immunol. 2011 Nov;4(6):648-57. doi: 10.1038/mi.2011.30. Epub 2011 Jul 6.

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