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Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation.

Yu X, Zhao Q, Zhang X, Zhang H, Liu Y, Wu X, Li M, Li X, Zhang J, Ruan X, Zhang H.

Oncotarget. 2017 Jun 27;8(40):67300-67314. doi: 10.18632/oncotarget.18619. eCollection 2017 Sep 15.


Celastrol Attenuates Multiple Sclerosis and Optic Neuritis in an Experimental Autoimmune Encephalomyelitis Model.

Yang H, Liu C, Jiang J, Wang Y, Zhang X.

Front Pharmacol. 2017 Feb 10;8:44. doi: 10.3389/fphar.2017.00044. eCollection 2017.


PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis.

Chirumbolo S, Bjørklund G.

Int J Mol Sci. 2017 Jan 15;18(1). pii: E165. doi: 10.3390/ijms18010165. Review.


Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii.

Iman V, Mohan S, Abdelwahab SI, Karimian H, Nordin N, Fadaeinasab M, Noordin MI, Noor SM.

Drug Des Devel Ther. 2016 Dec 28;11:103-121. doi: 10.2147/DDDT.S115135. eCollection 2017.


Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells.

Yang L, Liu Y, Wang M, Qian Y, Dai X, Zhu Y, Chen J, Guo S, Hisamitsu T.

Oncol Lett. 2016 Nov;12(5):3771-3778. Epub 2016 Sep 29.


Epigallocatechin-3-gallate protects against hepatic ischaemia-reperfusion injury by reducing oxidative stress and apoptotic cell death.

Tak E, Park GC, Kim SH, Jun DY, Lee J, Hwang S, Song GW, Lee SG.

J Int Med Res. 2016 Dec;44(6):1248-1262. doi: 10.1177/0300060516662735. Epub 2016 Nov 2.


Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion.

De Santis S, Kunde D, Serino G, Galleggiante V, Caruso ML, Mastronardi M, Cavalcanti E, Ranson N, Pinto A, Campiglia P, Santino A, Eri R, Chieppa M.

Oncotarget. 2016 Nov 15;7(46):75800-75809. doi: 10.18632/oncotarget.12415.


Parthenolide-Induced Cytotoxicity in H9c2 Cardiomyoblasts Involves Oxidative Stress.

Tsai TY, Chan P, Gong CL, Wong KL, Su TH, Shen PC, Leung YM, Liu ZM.

Acta Cardiol Sin. 2015 Jan;31(1):33-41.


Glucotoxicity Induced Oxidative Stress and Inflammation In Vivo and In Vitro in Psammomys obesus: Involvement of Aqueous Extract of Brassica rapa rapifera.

Berdja S, Smail L, Saka B, Neggazi S, Haffaf el-M, Benazzoug Y, Kacimi G, Boudarene L, Aouichat Bouguerra S.

Evid Based Complement Alternat Med. 2016;2016:3689208. doi: 10.1155/2016/3689208. Epub 2016 Mar 7.


Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation.

Qin S, Ang E, Dai L, Yang X, Ye D, Chen H, Zhou L, Yang M, Teguh D, Tan R, Xu J, Tickner J, Pavlos NJ, Xu J.

Int J Mol Sci. 2015 Nov 5;16(11):26599-607. doi: 10.3390/ijms161125972.


Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol.

Cao L, Zhang X, Cao F, Wang Y, Shen Y, Yang C, Uzan G, Peng B, Zhang D.

BMC Cancer. 2015 Nov 9;15:873. doi: 10.1186/s12885-015-1909-2.


Inhibition of inflammatory arthritis using fullerene nanomaterials.

Dellinger AL, Cunin P, Lee D, Kung AL, Brooks DB, Zhou Z, Nigrovic PA, Kepley CL.

PLoS One. 2015 Apr 16;10(4):e0126290. doi: 10.1371/journal.pone.0126290. eCollection 2015.


Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Navarro SL, Schwarz Y, Song X, Wang CY, Chen C, Trudo SP, Kristal AR, Kratz M, Eaton DL, Lampe JW.

J Nutr. 2014 Nov;144(11):1850-7. doi: 10.3945/jn.114.197434. Epub 2014 Aug 27.


Celastrol inhibits lung infiltration in differential syndrome animal models by reducing TNF-α and ICAM-1 levels while preserving differentiation in ATRA-induced acute promyelocytic leukemia cells.

Xu LM, Zheng YJ, Wang Y, Yang Y, Cao FF, Peng B, Xu XF, An HZ, Zheng AX, Zhang DH, Uzan G, Yu YZ.

PLoS One. 2014 Aug 12;9(8):e105131. doi: 10.1371/journal.pone.0105131. eCollection 2014.


Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progress.

Fürst R, Zündorf I.

Mediators Inflamm. 2014;2014:146832. doi: 10.1155/2014/146832. Epub 2014 May 29. Review.


Propolis Reduces Phosphatidylcholine-Specific Phospholipase C Activity and Increases Annexin a7 Level in Oxidized-LDL-Stimulated Human Umbilical Vein Endothelial Cells.

Xuan H, Li Z, Wang J, Wang K, Fu C, Yuan J, Hu F.

Evid Based Complement Alternat Med. 2014;2014:465383. doi: 10.1155/2014/465383. Epub 2014 Apr 22.


Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages.

Jeong JW, Lee HH, Han MH, Kim GY, Hong SH, Park C, Choi YH.

BMC Complement Altern Med. 2014 Mar 15;14:101. doi: 10.1186/1472-6882-14-101.


Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β.

Liu D, Wu A, Cui L, Hao R, Wang Y, He J, Guo D.

PLoS One. 2014 Mar 11;9(3):e91658. doi: 10.1371/journal.pone.0091658. eCollection 2014.


Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosides from Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells.

Cho K, Song SB, Tung NH, Kim KE, Kim YH.

Biomol Ther (Seoul). 2014 Jan;22(1):55-61. doi: 10.4062/biomolther.2013.096.

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