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A conformational switch regulates the ubiquitin ligase HUWE1.

Sander B, Xu W, Eilers M, Popov N, Lorenz S.

Elife. 2017 Feb 14;6. pii: e21036. doi: 10.7554/eLife.21036.


CRY2 and FBXL3 Cooperatively Degrade c-MYC.

Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM, Lamia KA.

Mol Cell. 2016 Nov 17;64(4):774-789. doi: 10.1016/j.molcel.2016.10.012.


p14 expression differences in ovarian benign, borderline and malignant epithelial tumors.

Cabral VD, Cerski MR, Sa Brito IT, Kliemann LM.

J Ovarian Res. 2016 Oct 22;9(1):69.


Elimination of p19ARF-expressing cells enhances pulmonary function in mice.

Hashimoto M, Asai A, Kawagishi H, Mikawa R, Iwashita Y, Kanayama K, Sugimoto K, Sato T, Maruyama M, Sugimoto M.

JCI Insight. 2016 Aug 4;1(12):e87732.


Emerging roles of p53 and other tumour-suppressor genes in immune regulation.

Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW.

Nat Rev Immunol. 2016 Dec;16(12):741-750. doi: 10.1038/nri.2016.99. Review.


MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo.

Xie Y, Lu W, Liu S, Yang Q, Goodwin JS, Sathyanarayana SA, Pratap S, Chen Z.

Oncotarget. 2016 Jul 26;7(30):47609-47619. doi: 10.18632/oncotarget.10251.


Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors.

Saito K, Iioka H, Kojima C, Ogawa M, Kondo E.

Cancer Sci. 2016 Sep;107(9):1290-301. doi: 10.1111/cas.12991.


JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression.

Prause M, Mayer CM, Brorsson C, Frederiksen KS, Billestrup N, Størling J, Mandrup-Poulsen T.

J Diabetes Res. 2016;2016:1312705. doi: 10.1155/2016/1312705.


Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation.

Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.

J Biol Chem. 2016 May 13;291(20):10541-50. doi: 10.1074/jbc.M115.706481.


Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation.

Micewicz ED, Sharma S, Waring AJ, Luong HT, McBride WH, Ruchala P.

Int J Pept Res Ther. 2016 Mar 1;22(1):67-81.


Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.

Csizmok V, Follis AV, Kriwacki RW, Forman-Kay JD.

Chem Rev. 2016 Jun 8;116(11):6424-62. doi: 10.1021/acs.chemrev.5b00548. Review.


Nucleostemin: New Stabilizer of ARF.

Cao B, Lu H.

Oncoscience. 2015 Dec 30;2(12):940-1. No abstract available.


NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2.

Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y, Du X.

EMBO Rep. 2016 Mar;17(3):349-66. doi: 10.15252/embr.201540505.


Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a.

Shields BJ, Jackson JT, Metcalf D, Shi W, Huang Q, Garnham AL, Glaser SP, Beck D, Pimanda JE, Bogue CW, Smyth GK, Alexander WS, McCormack MP.

Genes Dev. 2016 Jan 1;30(1):78-91. doi: 10.1101/gad.268425.115.


To Know How a Gene Works, We Need to Redefine It First but then, More Importantly, to Let the Cell Itself Decide How to Transcribe and Process Its RNAs.

Jia Y, Chen L, Ma Y, Zhang J, Xu N, Liao DJ.

Int J Biol Sci. 2015 Nov 19;11(12):1413-23. doi: 10.7150/ijbs.13436. Review.


The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration.

Hesse RG, Kouklis GK, Ahituv N, Pomerantz JH.

Elife. 2015 Nov 17;4. pii: e07702. doi: 10.7554/eLife.07702.


Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumors.

Dong P, Ihira K, Hamada J, Watari H, Yamada T, Hosaka M, Hanley SJ, Kudo M, Sakuragi N.

Oncotarget. 2015 Aug 21;6(24):19968-75. Review.


Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation.

Zheng J, Lang Y, Zhang Q, Cui D, Sun H, Jiang L, Chen Z, Zhang R, Gao Y, Tian W, Wu W, Tang J, Chen Z.

Genes Dev. 2015 Jul 15;29(14):1524-34. doi: 10.1101/gad.261792.115.


Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death.

Lee CK, Yang Y, Chen C, Liu J.

Oncogene. 2016 Apr 14;35(15):1988-95. doi: 10.1038/onc.2015.275.


STAT3 regulated ARF expression suppresses prostate cancer metastasis.

Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.

Nat Commun. 2015 Jul 22;6:7736. doi: 10.1038/ncomms8736. Erratum in: Nat Commun. 2015;6:8802.

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