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Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity.

Loveridge CJ, van 't Hof RJ, Charlesworth G, King A, Tan EH, Rose L, Daroszewska A, Prior A, Ahmad I, Welsh M, Mui EJ, Ford C, Salji M, Sansom O, Blyth K, Leung HY.

Sci Rep. 2017 Oct 16;7(1):13241. doi: 10.1038/s41598-017-13346-8.


Glutamine up-regulates MAPK phosphatase-1 induction via activation of Ca2+→ ERK cascade pathway.

Ayush O, Jin ZW, Kim HK, Shin YR, Im SY, Lee HK.

Biochem Biophys Rep. 2016 May 12;7:10-19. doi: 10.1016/j.bbrep.2016.05.011. eCollection 2016 Sep.


Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration.

Sarhan AR, Szyroka J, Begum S, Tomlinson MG, Hotchin NA, Heath JK, Cunningham DL.

Sci Rep. 2017 Jun 21;7(1):3970. doi: 10.1038/s41598-017-04015-x.


Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis.

Loveridge CJ, Mui EJ, Patel R, Tan EH, Ahmad I, Welsh M, Galbraith J, Hedley A, Nixon C, Blyth K, Sansom O, Leung HY.

Cancer Res. 2017 Jun 15;77(12):3158-3168. doi: 10.1158/0008-5472.CAN-16-2565. Epub 2017 May 17.


IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes.

Luo M, Yeruva S, Liu Y, Chodisetti G, Riederer B, Menon MB, Tachibana K, Doi T, Seidler UE.

Front Physiol. 2017 Feb 7;8:61. doi: 10.3389/fphys.2017.00061. eCollection 2017.


The Role of ERK1/2 in the Development of Diabetic Cardiomyopathy.

Xu Z, Sun J, Tong Q, Lin Q, Qian L, Park Y, Zheng Y.

Int J Mol Sci. 2016 Dec 8;17(12). pii: E2001. Review.


Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling.

Chen H, Wang Q, Shi D, Yao D, Zhang L, Xiong J, Xu B.

J Toxicol Pathol. 2016 Oct;29(4):253-259. Epub 2016 Sep 21.


Nuclear ERK5 inhibits progression of leukemic monocytes to macrophages by regulating the transcription factor PU.1 and heat shock protein HSP70.

Zheng R, Studzinski GP.

Leuk Lymphoma. 2017 Jun;58(6):1468-1480. doi: 10.1080/10428194.2016.1243675. Epub 2016 Oct 17.


The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation.

Zhang N, Liu L, Fan N, Zhang Q, Wang W, Zheng M, Ma L, Li Y, Shi L.

Oncotarget. 2016 Sep 20;7(38):61587-61600. doi: 10.18632/oncotarget.11402.


EGCG Suppresses ERK5 Activation to Reverse Tobacco Smoke-Triggered Gastric Epithelial-Mesenchymal Transition in BALB/c Mice.

Lu L, Chen J, Tang H, Bai L, Lu C, Wang K, Li M, Yan Y, Tang L, Wu R, Ye Y, Jin L, Liang Z.

Nutrients. 2016 Jul 20;8(7). pii: E380. doi: 10.3390/nu8070380.


Regulation of Stress Responses and Translational Control by Coronavirus.

Fung TS, Liao Y, Liu DX.

Viruses. 2016 Jul 4;8(7). pii: E184. doi: 10.3390/v8070184. Review.


ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.

de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E.

Nat Commun. 2016 May 17;7:11551. doi: 10.1038/ncomms11551.


Effect of Cigarette Smoking on Epithelial to Mesenchymal Transition (EMT) in Lung Cancer.

Vu T, Jin L, Datta PK.

J Clin Med. 2016 Apr 11;5(4). pii: E44. doi: 10.3390/jcm5040044. Review.


African Trypanosome-Induced Blood-Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation.

Sumpio BJ, Chitragari G, Moriguchi T, Shalaby S, Pappas-Brown V, Khan AM, Sekaran SD, Sumpio BE, Grab DJ.

Int J Angiol. 2015 Mar;24(1):41-6. doi: 10.1055/s-0034-1370890. Epub 2014 Jun 9.


Immobilized epidermal growth factor stimulates persistent, directed keratinocyte migration via activation of PLCγ1.

Kim CS, Mitchell IP, Desotell AW, Kreeger PK, Masters KS.

FASEB J. 2016 Jul;30(7):2580-90. doi: 10.1096/fj.201600252. Epub 2016 Mar 29.


Effects of Wenyangzhenshuai Granule on ERK1/2 and ERK5 activity in the myocardial tissue in a rabbit model of adriamycin-induced chronic heart failure.

Chen X, Cai H, Chen Q, Xie H, Liu Y, Lu Q, Tang Y.

Int J Clin Exp Med. 2015 Nov 15;8(11):20732-41. eCollection 2015.


ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial-mesenchymal transition.

Liang Z, Xie W, Wu R, Geng H, Zhao L, Xie C, Li X, Huang C, Zhu J, Zhu M, Zhu W, Wu J, Geng S, Zhong C.

Oncotarget. 2015 Aug 14;6(23):19605-18.


ERK5 Mediated Signalling in Diabetic Retinopathy.

Wu Y, Chakrabarti S.

Med Hypothesis Discov Innov Ophthalmol. 2015 Spring;4(1):17-26. Review.


Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.

Chu UB, Duellman T, Weaver SJ, Tao Y, Yang J.

Biochim Biophys Acta. 2015 Jul;1850(7):1415-25. doi: 10.1016/j.bbagen.2015.03.011. Epub 2015 Mar 28.

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