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Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults.

Roe AJ, Zhang S, Bhadelia RA, Johnson EJ, Lichtenstein AH, Rogers GT, Rosenberg IH, Smith CE, Zeisel SH, Scott TM.

Am J Clin Nutr. 2017 Jun;105(6):1283-1290. doi: 10.3945/ajcn.116.137158. Epub 2017 Mar 29.


Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing.

Guo Y, Hwang LD, Li J, Eades J, Yu CW, Mansfield C, Burdick-Will A, Chang X, Chen Y, Duke FF, Zhang J, Fakharzadeh S, Fennessey P, Keating BJ, Jiang H, Hakonarson H, Reed DR, Preti G.

BMC Med Genet. 2017 Feb 15;18(1):11. doi: 10.1186/s12881-017-0369-8.


Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase.

van der Veen JN, Lingrell S, Gao X, Takawale A, Kassiri Z, Vance DE, Jacobs RL.

J Lipid Res. 2017 Apr;58(4):656-667. doi: 10.1194/jlr.M070631. Epub 2017 Feb 3.


Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.

Ganz AB, Cohen VV, Swersky CC, Stover J, Vitiello GA, Lovesky J, Chuang JC, Shields K, Fomin VG, Lopez YS, Mohan S, Ganti A, Carrier B, Malysheva OV, Caudill MA.

Int J Mol Sci. 2017 Jan 26;18(2). pii: E252. doi: 10.3390/ijms18020252.


Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.

Ganz AB, Shields K, Fomin VG, Lopez YS, Mohan S, Lovesky J, Chuang JC, Ganti A, Carrier B, Yan J, Taeswuan S, Cohen VV, Swersky CC, Stover JA, Vitiello GA, Malysheva OV, Mudrak E, Caudill MA.

FASEB J. 2016 Oct;30(10):3321-3333. Epub 2016 Jun 24.


The Pediatric Methionine Requirement Should Incorporate Remethylation Potential and Transmethylation Demands.

Robinson JL, Bertolo RF.

Adv Nutr. 2016 May 16;7(3):523-34. doi: 10.3945/an.115.010843. Print 2016 May. Review.


Sharpening Precision Medicine by a Thorough Interrogation of Metabolic Individuality.

Beebe K, Kennedy AD.

Comput Struct Biotechnol J. 2016 Jan 21;14:97-105. doi: 10.1016/j.csbj.2016.01.001. eCollection 2016. Review.


Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.

Nilsson TK, Hurtig-Wennlöf A, Sjöström M, Herrmann W, Obeid R, Owen JR, Zeisel S.

FASEB J. 2016 Apr;30(4):1683-8. doi: 10.1096/fj.15-281097. Epub 2016 Jan 4.


Choline metabolites: gene by diet interactions.

Smallwood T, Allayee H, Bennett BJ.

Curr Opin Lipidol. 2016 Feb;27(1):33-9. doi: 10.1097/MOL.0000000000000259. Review.


Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain.

Tyler CR, Hafez AK, Solomon ER, Allan AM.

Toxicol Appl Pharmacol. 2015 Oct 1;288(1):40-51. doi: 10.1016/j.taap.2015.07.013. Epub 2015 Jul 17.


Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

Silver MJ, Corbin KD, Hellenthal G, da Costa KA, Dominguez-Salas P, Moore SE, Owen J, Prentice AM, Hennig BJ, Zeisel SH.

FASEB J. 2015 Aug;29(8):3426-35. doi: 10.1096/fj.15-271056. Epub 2015 Apr 28.


Improved method for quantitative analysis of methylated phosphatidylethanolamine species and its application for analysis of diabetic-mouse liver samples.

Wang M, Kim GH, Wei F, Chen H, Altarejos J, Han X.

Anal Bioanal Chem. 2015 Jul;407(17):5021-32. doi: 10.1007/s00216-015-8534-4. Epub 2015 Mar 1.


Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.

Park S, Choi SG, Yoo SM, Son JH, Jung YK.

Autophagy. 2014;10(11):1906-20. doi: 10.4161/auto.32177. Epub 2014 Oct 30.


Increased phosphatidylethanolamine N-methyltransferase gene expression in non-small-cell lung cancer tissue predicts shorter patient survival.

Zinrajh D, Hörl G, Jürgens G, Marc J, Sok M, Cerne D.

Oncol Lett. 2014 Jun;7(6):2175-2179. Epub 2014 Apr 4.


Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH.

FASEB J. 2014 Jul;28(7):2970-8. doi: 10.1096/fj.14-249557. Epub 2014 Mar 26.


Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders.

Hamlin JC, Pauly M, Melnyk S, Pavliv O, Starrett W, Crook TA, James SJ.

Autism Res Treat. 2013;2013:578429. doi: 10.1155/2013/578429. Epub 2013 Dec 16.


Nutrition in pregnancy: the argument for including a source of choline.

Zeisel SH.

Int J Womens Health. 2013 Apr 22;5:193-9. doi: 10.2147/IJWH.S36610. Print 2013.


Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.

Mehedint MG, Zeisel SH.

Curr Opin Clin Nutr Metab Care. 2013 May;16(3):339-45. doi: 10.1097/MCO.0b013e3283600d46. Review.


Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH.

FASEB J. 2013 Apr;27(4):1674-89. doi: 10.1096/fj.12-219097. Epub 2013 Jan 4.

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