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Skeletal muscle inflammation and insulin resistance in obesity.

Wu H, Ballantyne CM.

J Clin Invest. 2017 Jan 3;127(1):43-54. doi: 10.1172/JCI88880.


Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2.

Wang Y, Qian Y, Fang Q, Zhong P, Li W, Wang L, Fu W, Zhang Y, Xu Z, Li X, Liang G.

Nat Commun. 2017 Jan 3;8:13997. doi: 10.1038/ncomms13997.


Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance.

Li H, Fang M, Xu M, Li S, Du J, Li W, Chen H.

PLoS One. 2016 Dec 14;11(12):e0167930. doi: 10.1371/journal.pone.0167930.


Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice.

Warfel JD, Bermudez EM, Mendoza TM, Ghosh S, Zhang J, Elks CM, Mynatt R, Vandanmagsar B.

Sci Rep. 2016 Nov 28;6:37941. doi: 10.1038/srep37941.


Obesity decreases B cell responses in young and elderly individuals.

Frasca D, Ferracci F, Diaz A, Romero M, Lechner S, Blomberg BB.

Obesity (Silver Spring). 2016 Mar;24(3):615-25. doi: 10.1002/oby.21383.


Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes.

Martínez-García C, Izquierdo-Lahuerta A, Vivas Y, Velasco I, Yeo TK, Chen S, Medina-Gomez G.

PLoS One. 2015 Nov 6;10(11):e0142291. doi: 10.1371/journal.pone.0142291.


Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin.

Kim JA, Jang HJ, Hwang DH.

Am J Physiol Endocrinol Metab. 2015 Nov 1;309(9):E767-76. doi: 10.1152/ajpendo.00369.2015.


Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles.

Péladeau C, Ahmed A, Amirouche A, Crawford Parks TE, Bronicki LM, Ljubicic V, Renaud JM, Jasmin BJ.

Hum Mol Genet. 2016 Jan 1;25(1):24-43. doi: 10.1093/hmg/ddv444.


Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway.

Tao W, Wu J, Xie BX, Zhao YY, Shen N, Jiang S, Wang XX, Xu N, Jiang C, Chen S, Gao X, Xue B, Li CJ.

J Biol Chem. 2015 Aug 14;290(33):20086-97. doi: 10.1074/jbc.M115.657742.


Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.

Perdomo L, Beneit N, Otero YF, Escribano Ó, Díaz-Castroverde S, Gómez-Hernández A, Benito M.

Cardiovasc Diabetol. 2015 Jun 10;14:75. doi: 10.1186/s12933-015-0237-9.


Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition.

Hameed I, Masoodi SR, Mir SA, Nabi M, Ghazanfar K, Ganai BA.

World J Diabetes. 2015 May 15;6(4):598-612. doi: 10.4239/wjd.v6.i4.598. Review.


The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management.

Krause M, Heck TG, Bittencourt A, Scomazzon SP, Newsholme P, Curi R, Homem de Bittencourt PI Jr.

Mediators Inflamm. 2015;2015:249205. doi: 10.1155/2015/249205. Review.


Trypanosoma cruzi infection is a potent risk factor for non-alcoholic steatohepatitis enhancing local and systemic inflammation associated with strong oxidative stress and metabolic disorders.

Onofrio LI, Arocena AR, Paroli AF, Cabalén ME, Andrada MC, Cano RC, Gea S.

PLoS Negl Trop Dis. 2015 Feb 10;9(2):e0003464. doi: 10.1371/journal.pntd.0003464.


Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance.

Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG, Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD.

EMBO Mol Med. 2015 Feb 9;7(3):259-74. doi: 10.15252/emmm.201404169.


Maternal adiponectin controls milk composition to prevent neonatal inflammation.

Jin Z, Du Y, Schwaid AG, Asterholm IW, Scherer PE, Saghatelian A, Wan Y.

Endocrinology. 2015 Apr;156(4):1504-13. doi: 10.1210/en.2014-1738.


Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization.

Jin Z, Wei W, Yang M, Du Y, Wan Y.

Cell Metab. 2014 Sep 2;20(3):483-98. doi: 10.1016/j.cmet.2014.07.011.


Linking obesity with type 2 diabetes: the role of T-bet.

Wali JA, Thomas HE, Sutherland AP.

Diabetes Metab Syndr Obes. 2014 Jul 22;7:331-40. doi: 10.2147/DMSO.S51432. Review.


Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress.

Verma MK, Yateesh AN, Neelima K, Pawar N, Sandhya K, Poornima J, Lakshmi MN, Yogeshwari S, Pallavi PM, Oommen AM, Somesh BP, Jagannath MR.

Springerplus. 2014 May 20;3:255. doi: 10.1186/2193-1801-3-255.


Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation.

Peverill W, Powell LW, Skoien R.

Int J Mol Sci. 2014 May 14;15(5):8591-638. doi: 10.3390/ijms15058591. Review.


Acylcarnitines activate proinflammatory signaling pathways.

Rutkowsky JM, Knotts TA, Ono-Moore KD, McCoin CS, Huang S, Schneider D, Singh S, Adams SH, Hwang DH.

Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1378-87. doi: 10.1152/ajpendo.00656.2013.

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