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Assembly-induced folding regulates interleukin 12 biogenesis and secretion.

Reitberger S, Haimerl P, Aschenbrenner I, Esser-von Bieren J, Feige MJ.

J Biol Chem. 2017 May 12;292(19):8073-8081. doi: 10.1074/jbc.M117.782284. Epub 2017 Mar 21.


Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.

Huang J, Liu Y, Au BC, Barber DL, Arruda A, Schambach A, Rothe M, Minden MD, Paige CJ, Medin JA.

Mol Ther Methods Clin Dev. 2016 Dec 7;3:16074. eCollection 2016.


Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins.

Venetz D, Koovely D, Weder B, Neri D.

J Biol Chem. 2016 Aug 26;291(35):18139-47. doi: 10.1074/jbc.M116.737734. Epub 2016 Jul 8.


Interleukin-12 inhibits pathological neovascularization in mouse model of oxygen-induced retinopathy.

Zhou Y, Yoshida S, Kubo Y, Kobayashi Y, Nakama T, Yamaguchi M, Ishikawa K, Nakao S, Ikeda Y, Ishibashi T, Sonoda KH.

Sci Rep. 2016 Jun 17;6:28140. doi: 10.1038/srep28140.


Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis.

Jang JC, Lee KM, Ko SG.

Mediators Inflamm. 2016;2016:9275083. doi: 10.1155/2016/9275083. Epub 2016 May 17.


Optimization of canine interleukin-12 production using a baculovirus insect cell expression system.

de Pinheiro CG, Pedrosa Mde O, Teixeira NC, Ano Bom AP, van Oers MM, Oliveira GG.

BMC Res Notes. 2016 Jan 22;9:36. doi: 10.1186/s13104-016-1843-7.


Medroxyprogesterone acetate differentially regulates interleukin (IL)-12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid receptor (GR)-dependent manner.

Louw-du Toit R, Hapgood JP, Africander D.

J Biol Chem. 2014 Nov 7;289(45):31136-49. doi: 10.1074/jbc.M114.587311. Epub 2014 Sep 8.


New insights into IL-12-mediated tumor suppression.

Tugues S, Burkhard SH, Ohs I, Vrohlings M, Nussbaum K, Vom Berg J, Kulig P, Becher B.

Cell Death Differ. 2015 Feb;22(2):237-46. doi: 10.1038/cdd.2014.134. Epub 2014 Sep 5. Review.


In case of obesity, longevity-related mechanisms lead to anti-inflammation.

Kaya MS, Bay─▒roglu F, Mis L, Kilinc D, Comba B.

Age (Dordr). 2014 Apr;36(2):677-87. doi: 10.1007/s11357-013-9598-8. Epub 2013 Dec 4.


NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.

Fleming JD, Pavesi G, Benatti P, Imbriano C, Mantovani R, Struhl K.

Genome Res. 2013 Aug;23(8):1195-209. doi: 10.1101/gr.148080.112. Epub 2013 Apr 17.


Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages.

Fraternale A, Crinelli R, Casabianca A, Paoletti MF, Orlandi C, Carloni E, Smietana M, Palamara AT, Magnani M.

PLoS One. 2013;8(3):e57866. doi: 10.1371/journal.pone.0057866. Epub 2013 Mar 11.


Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.

Johnston A, Xing X, Swindell WR, Kochkodan J, Riblett M, Nair RP, Stuart PE, Ding J, Voorhees JJ, Elder JT, Gudjonsson JE.

Hum Mol Genet. 2013 May 1;22(9):1807-15. doi: 10.1093/hmg/ddt034. Epub 2013 Jan 31.


The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.

Jalah R, Rosati M, Ganneru B, Pilkington GR, Valentin A, Kulkarni V, Bergamaschi C, Chowdhury B, Zhang GM, Beach RK, Alicea C, Broderick KE, Sardesai NY, Pavlakis GN, Felber BK.

J Biol Chem. 2013 Mar 1;288(9):6763-76. doi: 10.1074/jbc.M112.436675. Epub 2013 Jan 7.


Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.

Hussain SK, Madeleine MM, Johnson LG, Du Q, Galloway DA, Daling JR, Malkki M, Petersdorf EW, Schwartz SM.

Int J Cancer. 2013 Jul;133(1):201-13. doi: 10.1002/ijc.28000. Epub 2013 Feb 12.


Bladder Cancer Immunotherapy: BCG and Beyond.

Askeland EJ, Newton MR, O'Donnell MA, Luo Y.

Adv Urol. 2012;2012:181987. doi: 10.1155/2012/181987. Epub 2012 Jun 20.


Characterization of the expression, promoter activity and molecular architecture of fibin.

Lakner J, Seyer C, Hermsdorf T, Sch├Âneberg T.

BMC Biochem. 2011 May 26;12:26. doi: 10.1186/1471-2091-12-26.


Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment.

Zhang L, Kerkar SP, Yu Z, Zheng Z, Yang S, Restifo NP, Rosenberg SA, Morgan RA.

Mol Ther. 2011 Apr;19(4):751-9. doi: 10.1038/mt.2010.313. Epub 2011 Feb 1.


Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression.

Liu J, Cao S, Kim S, Chung EY, Homma Y, Guan X, Jimenez V, Ma X.

Curr Immunol Rev. 2005 Jun;1(2):119-137.


Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes.

Guzzo C, Che Mat NF, Gee K.

J Biol Chem. 2010 Aug 6;285(32):24404-11. doi: 10.1074/jbc.M110.112599. Epub 2010 Jun 2. Erratum in: J Biol Chem. 2012 Mar 9;287(11):8661.

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