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Items: 1 to 20 of 144

1.

De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer.

Tadros S, Shukla SK, King RJ, Gunda V, Vernucci E, Abrego J, Chaika NV, Yu F, Lazenby AJ, Berim L, Grem J, Sasson AR, Singh PK.

Cancer Res. 2017 Oct 15;77(20):5503-5517. doi: 10.1158/0008-5472.CAN-16-3062. Epub 2017 Aug 15.

PMID:
28811332
2.

A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin.

Qiu L, Tian K, Pan J, Jiang L, Yang H, Zhu X, Shen B, Duan Y, Huang Y.

Tetrahedron. 2017 Feb 9;73(6):771-775. doi: 10.1016/j.tet.2016.12.059. Epub 2016 Dec 28.

PMID:
28626267
3.

Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid.

Falzone M, Crespo E, Jones K, Khan G, Korn VL, Patel A, Patel M, Patel K, Perkins C, Siddiqui S, Stenger D, Yu E, Gelber M, Scheffler R, Nayda V, Ravin A, Komal R, Rudolf JD, Shen B, Gullo V, Demain AL.

J Antibiot (Tokyo). 2017 Jul;70(7):828-831. doi: 10.1038/ja.2017.49. Epub 2017 May 3.

4.

Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.

Brill ZG, Condakes ML, Ting CP, Maimone TJ.

Chem Rev. 2017 Sep 27;117(18):11753-11795. doi: 10.1021/acs.chemrev.6b00834. Epub 2017 Mar 15. Review.

PMID:
28293944
5.

Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application.

Kerantzas CA, Jacobs WR Jr.

MBio. 2017 Mar 14;8(2). pii: e01586-16. doi: 10.1128/mBio.01586-16. Review.

6.

In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin.

Dong LB, Rudolf JD, Lin L, Ruiz C, Cameron MD, Shen B.

Bioorg Med Chem. 2017 Mar 15;25(6):1990-1996. doi: 10.1016/j.bmc.2017.02.028. Epub 2017 Feb 16.

PMID:
28237556
7.

Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders.

Stefano GB, Samuel J, Kream RM.

Med Sci Monit. 2017 Jan 7;23:101-106. Review.

8.

Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes.

Soares da Costa TP, Nanson JD, Forwood JK.

Sci Rep. 2017 Jan 3;7:39277. doi: 10.1038/srep39277.

9.

Biosynthetic Origin of the Ether Ring in Platensimycin.

Rudolf JD, Dong LB, Manoogian K, Shen B.

J Am Chem Soc. 2016 Dec 28;138(51):16711-16721. doi: 10.1021/jacs.6b09818. Epub 2016 Dec 14.

10.

Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine.

Rudolf JD, Dong LB, Shen B.

Biochem Pharmacol. 2017 Jun 1;133:139-151. doi: 10.1016/j.bcp.2016.11.013. Epub 2016 Nov 16. Review.

PMID:
27865713
11.

Substrate Trapping in Crystals of the Thiolase OleA Identifies Three Channels That Enable Long Chain Olefin Biosynthesis.

Goblirsch BR, Jensen MR, Mohamed FA, Wackett LP, Wilmot CM.

J Biol Chem. 2016 Dec 23;291(52):26698-26706. doi: 10.1074/jbc.M116.760892. Epub 2016 Nov 4.

12.

Competitive Growth Enhances Conditional Growth Mutant Sensitivity to Antibiotics and Exposes a Two-Component System as an Emerging Antibacterial Target in Burkholderia cenocepacia.

Gislason AS, Choy M, Bloodworth RA, Qu W, Stietz MS, Li X, Zhang C, Cardona ST.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e00790-16. doi: 10.1128/AAC.00790-16. Print 2017 Jan.

13.

Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials.

Morvan C, Halpern D, Kénanian G, Hays C, Anba-Mondoloni J, Brinster S, Kennedy S, Trieu-Cuot P, Poyart C, Lamberet G, Gloux K, Gruss A.

Nat Commun. 2016 Oct 5;7:12944. doi: 10.1038/ncomms12944.

14.

The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.

Singh SB, Kang L, Nawrocki AR, Zhou D, Wu M, Previs S, Miller C, Liu H, Hines CD, Madeira M, Cao J, Herath K, Spears LD, Semenkovich CF, Wang L, Kelley DE, Li C, Guan HP.

PLoS One. 2016 Oct 3;11(10):e0164133. doi: 10.1371/journal.pone.0164133. eCollection 2016. Erratum in: PLoS One. 2017 Jan 19;12 (1):e0170721. Spears, Larry D [added]; Semenkovich, Clay F [added].

15.

A Mutasynthetic Library of Platensimycin and Platencin Analogues.

Dong LB, Rudolf JD, Shen B.

Org Lett. 2016 Sep 16;18(18):4606-9. doi: 10.1021/acs.orglett.6b02248. Epub 2016 Sep 6.

16.

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ.

J Med Chem. 2016 Jun 9;59(11):5377-90. doi: 10.1021/acs.jmedchem.6b00236. Epub 2016 May 24.

17.

Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029.

Dong LB, Rudolf JD, Shen B.

Bioorg Med Chem. 2016 Dec 15;24(24):6348-6353. doi: 10.1016/j.bmc.2016.04.026. Epub 2016 Apr 13.

18.

Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026.

Shi J, Pan J, Liu L, Yang D, Lu S, Zhu X, Shen B, Duan Y, Huang Y.

J Ind Microbiol Biotechnol. 2016 Jul;43(7):1027-35. doi: 10.1007/s10295-016-1769-z. Epub 2016 Apr 28.

19.

Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens.

He Y, Tian J, Chen X, Sun W, Zhu H, Li Q, Lei L, Yao G, Xue Y, Wang J, Li H, Zhang Y.

Sci Rep. 2016 Apr 11;6:24291. doi: 10.1038/srep24291.

20.

A Review on Platensimycin: A Selective FabF Inhibitor.

Das M, Sakha Ghosh P, Manna K.

Int J Med Chem. 2016;2016:9706753. doi: 10.1155/2016/9706753. Epub 2016 Jan 28. Review.

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