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Items: 1 to 20 of 52

1.

Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia.

Fabbri G, Holmes AB, Viganotti M, Scuoppo C, Belver L, Herranz D, Yan XJ, Kieso Y, Rossi D, Gaidano G, Chiorazzi N, Ferrando AA, Dalla-Favera R.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2911-E2919. doi: 10.1073/pnas.1702564114. Epub 2017 Mar 17.

PMID:
28314854
2.

Synergistic antileukemic therapies in NOTCH1-induced T-ALL.

Sanchez-Martin M, Ambesi-Impiombato A, Qin Y, Herranz D, Bansal M, Girardi T, Paietta E, Tallman MS, Rowe JM, De Keersmaecker K, Califano A, Ferrando AA.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2006-2011. doi: 10.1073/pnas.1611831114. Epub 2017 Feb 7.

PMID:
28174276
3.

IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias.

Gusscott S, Jenkins CE, Lam SH, Giambra V, Pollak M, Weng AP.

PLoS One. 2016 Aug 17;11(8):e0161158. doi: 10.1371/journal.pone.0161158. eCollection 2016.

4.

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.

Adamowicz M, Vermezovic J, d'Adda di Fagagna F.

Cell Rep. 2016 Aug 23;16(8):2068-76. doi: 10.1016/j.celrep.2016.07.038. Epub 2016 Aug 11.

5.

Notch signaling: its roles and therapeutic potential in hematological malignancies.

Gu Y, Masiero M, Banham AH.

Oncotarget. 2016 May 17;7(20):29804-23. doi: 10.18632/oncotarget.7772. Review.

6.

A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.

Papayannidis C, DeAngelo DJ, Stock W, Huang B, Shaik MN, Cesari R, Zheng X, Reynolds JM, English PA, Ozeck M, Aster JC, Kuo F, Huang D, Lira PD, McLachlan KR, Kern KA, Garcia-Manero G, Martinelli G.

Blood Cancer J. 2015 Sep 25;5:e350. doi: 10.1038/bcj.2015.80. No abstract available.

7.

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Hubbard EJ, Kolesnick R.

PLoS One. 2015 Jun 29;10(6):e0127862. doi: 10.1371/journal.pone.0127862. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0141673.

8.

Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas.

Lee HO, He X, Mookerjee-Basu J, Zhongping D, Hua X, Nicolas E, Sulis ML, Ferrando AA, Testa JR, Kappes DJ.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7773-8. doi: 10.1073/pnas.1424104112. Epub 2015 Jun 8.

9.

Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms.

Yang L, Zhang S, George SK, Teng R, You X, Xu M, Liu H, Sun X, Amin HM, Shi W.

Oncotarget. 2015 Jun 20;6(17):14953-69.

10.

Therapeutic targeting of HES1 transcriptional programs in T-ALL.

Schnell SA, Ambesi-Impiombato A, Sanchez-Martin M, Belver L, Xu L, Qin Y, Kageyama R, Ferrando AA.

Blood. 2015 Apr 30;125(18):2806-14. doi: 10.1182/blood-2014-10-608448. Epub 2015 Mar 17.

11.

Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia.

Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner J, Wu H.

Cancer Res. 2014 Dec 1;74(23):7048-59. doi: 10.1158/0008-5472.CAN-14-1470. Epub 2014 Oct 6.

12.

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.

Herranz D, Ambesi-Impiombato A, Palomero T, Schnell SA, Belver L, Wendorff AA, Xu L, Castillo-Martin M, Llobet-Navás D, Cordon-Cardo C, Clappier E, Soulier J, Ferrando AA.

Nat Med. 2014 Oct;20(10):1130-7. doi: 10.1038/nm.3665. Epub 2014 Sep 7.

13.

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Ntziachristos P, Tsirigos A, Welstead GG, Trimarchi T, Bakogianni S, Xu L, Loizou E, Holmfeldt L, Strikoudis A, King B, Mullenders J, Becksfort J, Nedjic J, Paietta E, Tallman MS, Rowe JM, Tonon G, Satoh T, Kruidenier L, Prinjha R, Akira S, Van Vlierberghe P, Ferrando AA, Jaenisch R, Mullighan CG, Aifantis I.

Nature. 2014 Oct 23;514(7523):513-7. doi: 10.1038/nature13605. Epub 2014 Aug 17.

14.

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.

Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, Yuan J, Ware C, MacLean J, Garrett-Engele PW, Kluk M, Laskey J, Haines BB, Moskaluk C, Zawel L, Fawell S, Gilliland G, Zhang T, Kremer BE, Knoechel B, Bernstein BE, Pear WS, Liu XS, Aster JC, Sathyanarayanan S.

Cancer Discov. 2014 Oct;4(10):1154-67. doi: 10.1158/2159-8290.CD-13-0830. Epub 2014 Aug 7.

15.

Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.

Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A, Aifantis I.

Cell. 2014 Jul 31;158(3):593-606. doi: 10.1016/j.cell.2014.05.049.

16.

New Approaches to Target T-ALL.

Roti G, Stegmaier K.

Front Oncol. 2014 Jul 8;4:170. doi: 10.3389/fonc.2014.00170. eCollection 2014. Review.

17.

Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).

Cantley AM, Welsch M, Ambesi-Impiombato A, Sanchez-Martin M, Kim MY, Bauer A, Ferrando A, Stockwell BR.

ACS Med Chem Lett. 2014 Apr 25;5(7):754-9. doi: 10.1021/ml500044g. eCollection 2014 Jul 10.

18.

FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.

Fu W, Wang K, Zhao JL, Yu HC, Li SZ, Lin Y, Liang L, Huang SY, Liang YM, Han H, Qin HY.

BMC Cancer. 2014 Jun 22;14:463. doi: 10.1186/1471-2407-14-463.

19.

RasGRP Ras guanine nucleotide exchange factors in cancer.

Ksionda O, Limnander A, Roose JP.

Front Biol (Beijing). 2013 Oct 1;8(5):508-532.

20.

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):705-10. doi: 10.1073/pnas.1315023111. Epub 2013 Dec 27.

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