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Items: 14


Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer.

Kim SM.

Int J Mol Sci. 2016 Jul 19;17(7). pii: E1155. doi: 10.3390/ijms17071155. Review.


Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges.

Shankar E, Kanwal R, Candamo M, Gupta S.

Semin Cancer Biol. 2016 Oct;40-41:82-99. doi: 10.1016/j.semcancer.2016.04.002. Epub 2016 Apr 23. Review.


Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.

Yang AY, Kim H, Li W, Kong AN.

Curr Top Med Chem. 2016;16(7):697-713. Review.


Impact of Epigenetic Dietary Components on Cancer through Histone Modifications.

Gao Y, Tollefsbol TO.

Curr Med Chem. 2015;22(17):2051-64. Review.


Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models.

Kung PJ, Tao YC, Hsu HC, Chen WL, Lin TH, Janreddy D, Yao CF, Chang KH, Lin JY, Su MT, Wu CH, Lee-Chen GJ, Hsieh-Li HM.

Drug Des Devel Ther. 2014 Oct 16;8:1929-39. doi: 10.2147/DDDT.S67376. eCollection 2014.


Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy.

Ahmad A, Biersack B, Li Y, Kong D, Bao B, Schobert R, Padhye SB, Sarkar FH.

Anticancer Agents Med Chem. 2013 Sep;13(7):1002-13. Review.


Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes.

Chang HP, Wang ML, Hsu CY, Liu ME, Chan MH, Chen YH.

Int J Obes (Lond). 2011 Dec;35(12):1530-8. doi: 10.1038/ijo.2011.12. Epub 2011 Feb 22. Erratum in: Int J Obes (Lond). 2013 Feb;37(2):324.


A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation.

Wu Y, Feng X, Jin Y, Wu Z, Hankey W, Paisie C, Li L, Liu F, Barsky SH, Zhang W, Ganju R, Zou X.

Cancer Prev Res (Phila). 2010 Jul;3(7):818-28. doi: 10.1158/1940-6207.CAPR-09-0213. Epub 2010 Jun 29.


Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols.

Gross-Steinmeyer K, Stapleton PL, Tracy JH, Bammler TK, Strom SC, Buhler DR, Eaton DL.

Toxicol Sci. 2009 Dec;112(2):303-10. doi: 10.1093/toxsci/kfp206. Epub 2009 Sep 21.


OSU-A9, a potent indole-3-carbinol derivative, suppresses breast tumor growth by targeting the Akt-NF-kappaB pathway and stress response signaling.

Weng JR, Tsai CH, Omar HA, Sargeant AM, Wang D, Kulp SK, Shapiro CL, Chen CS.

Carcinogenesis. 2009 Oct;30(10):1702-9. doi: 10.1093/carcin/bgp202. Epub 2009 Aug 25.


Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.

Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM.

Cancer Res. 2009 Aug 1;69(15):6083-91. doi: 10.1158/0008-5472.CAN-08-3309. Epub 2009 Jul 21.


Cancer is a preventable disease that requires major lifestyle changes.

Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB.

Pharm Res. 2008 Sep;25(9):2097-116. doi: 10.1007/s11095-008-9661-9. Epub 2008 Jul 15. Review. Erratum in: Pharm Res. 2008 Sep;25(9):2200. Kunnumakara, Ajaikumar B [corrected to Kunnumakkara, Ajaikumar B].


Indole-3-carbinol as a chemopreventive and anti-cancer agent.

Weng JR, Tsai CH, Kulp SK, Chen CS.

Cancer Lett. 2008 Apr 18;262(2):153-63. doi: 10.1016/j.canlet.2008.01.033. Epub 2008 Mar 7. Review.


The search for endogenous activators of the aryl hydrocarbon receptor.

Nguyen LP, Bradfield CA.

Chem Res Toxicol. 2008 Jan;21(1):102-16. Epub 2007 Dec 13. Review.

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