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Fungal Ribotoxins: A Review of Potential Biotechnological Applications.

Olombrada M, Lázaro-Gorines R, López-Rodríguez JC, Martínez-Del-Pozo Á, Oñaderra M, Maestro-López M, Lacadena J, Gavilanes JG, García-Ortega L.

Toxins (Basel). 2017 Feb 21;9(2). pii: E71. doi: 10.3390/toxins9020071. Review.


Ricin uses arginine 235 as an anchor residue to bind to P-proteins of the ribosomal stalk.

Zhou Y, Li XP, Chen BY, Tumer NE.

Sci Rep. 2017 Feb 23;7:42912. doi: 10.1038/srep42912.


Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.

Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA.

Elife. 2016 May 9;5. pii: e14874. doi: 10.7554/eLife.14874.


Solution structure of the Z-DNA binding domain of PKR-like protein kinase from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition.

Lee AR, Park CJ, Cheong HK, Ryu KS, Park JW, Kwon MY, Lee J, Kim KK, Choi BS, Lee JH.

Nucleic Acids Res. 2016 Apr 7;44(6):2936-48. doi: 10.1093/nar/gkw025. Epub 2016 Jan 20.


Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.

J Biol Chem. 2013 Oct 18;288(42):30270-84. doi: 10.1074/jbc.M113.510966. Epub 2013 Sep 3.


Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteins.

McCluskey AJ, Bolewska-Pedyczak E, Jarvik N, Chen G, Sidhu SS, Gariépy J.

PLoS One. 2012;7(2):e31191. doi: 10.1371/journal.pone.0031191. Epub 2012 Feb 15.


Interaction of ricin and Shiga toxins with ribosomes.

Tumer NE, Li XP.

Curr Top Microbiol Immunol. 2012;357:1-18. doi: 10.1007/82_2011_174. Review.


Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach.

Pang YP, Park JG, Wang S, Vummenthala A, Mishra RK, McLaughlin JE, Di R, Kahn JN, Tumer NE, Janosi L, Davis J, Millard CB.

PLoS One. 2011 Mar 24;6(3):e17883. doi: 10.1371/journal.pone.0017883.


The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.

Plantinga MJ, Korennykh AV, Piccirilli JA, Correll CC.

Biochemistry. 2011 Apr 12;50(14):3004-13. doi: 10.1021/bi1018336. Epub 2011 Mar 18.


Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae.

Di R, Kyu E, Shete V, Saidasan H, Kahn PC, Tumer NE.

Toxicon. 2011 Mar 15;57(4):525-39. doi: 10.1016/j.toxicon.2010.12.006. Epub 2010 Dec 22.


Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurination.

Li XP, Grela P, Krokowski D, Tchórzewski M, Tumer NE.

J Biol Chem. 2010 Dec 31;285(53):41463-71. doi: 10.1074/jbc.M110.171793. Epub 2010 Oct 25.


Rate theories for biologists.

Zhou HX.

Q Rev Biophys. 2010 May;43(2):219-93. doi: 10.1017/S0033583510000120. Epub 2010 Aug 9. Review.


Cleavage of the sarcin-ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding.

García-Ortega L, Alvarez-García E, Gavilanes JG, Martínez-del-Pozo A, Joseph S.

Nucleic Acids Res. 2010 Jul;38(12):4108-19. doi: 10.1093/nar/gkq151. Epub 2010 Mar 9.


Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.

Ho MC, Sturm MB, Almo SC, Schramm VL.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20276-81. doi: 10.1073/pnas.0911606106. Epub 2009 Nov 17.


Dissection of the high rate constant for the binding of a ribotoxin to the ribosome.

Qin S, Zhou HX.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6974-9. doi: 10.1073/pnas.0900291106. Epub 2009 Apr 3. Erratum in: Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12208.


Alpha-sarcin catalytic activity is not required for cytotoxicity.

Alford SC, Pearson JD, Carette A, Ingham RJ, Howard PL.

BMC Biochem. 2009 Apr 3;10:9. doi: 10.1186/1471-2091-10-9.


A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.

Li XP, Chiou JC, Remacha M, Ballesta JP, Tumer NE.

Biochemistry. 2009 May 12;48(18):3853-63. doi: 10.1021/bi802371h.


Fundamental aspects of protein-protein association kinetics.

Schreiber G, Haran G, Zhou HX.

Chem Rev. 2009 Mar 11;109(3):839-60. doi: 10.1021/cr800373w. Review. No abstract available.


The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome.

Too PH, Ma MK, Mak AN, Wong YT, Tung CK, Zhu G, Au SW, Wong KB, Shaw PC.

Nucleic Acids Res. 2009 Feb;37(2):602-10. doi: 10.1093/nar/gkn922. Epub 2008 Dec 10.

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