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The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study.

Tan P, Tiong IS, Fleming S, Pomilio G, Cummings N, Droogleever M, McManus J, Schwarer A, Catalano J, Patil S, Avery S, Spencer A, Wei A.

Oncotarget. 2016 Nov 29;8(32):52269-52280. doi: 10.18632/oncotarget.13699. eCollection 2017 Aug 8.


Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells.

Roch A, Giger S, Girotra M, Campos V, Vannini N, Naveiras O, Gobaa S, Lutolf MP.

Nat Commun. 2017 Aug 9;8(1):221. doi: 10.1038/s41467-017-00291-3.


Emerging roles of transit-amplifying cells in tissue regeneration and cancer.

Zhang B, Hsu YC.

Wiley Interdiscip Rev Dev Biol. 2017 Sep;6(5). doi: 10.1002/wdev.282. Epub 2017 Jul 3. Review.


Specific Depletion of Leukemic Stem Cells: Can MicroRNAs Make the Difference?

Martiáñez Canales T, de Leeuw DC, Vermue E, Ossenkoppele GJ, Smit L.

Cancers (Basel). 2017 Jun 30;9(7). pii: E74. doi: 10.3390/cancers9070074. Review.


PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells.

Zagni C, Almeida LO, Balan T, Martins MT, Rosselli-Murai LK, Papagerakis P, Castilho RM, Squarize CH.

Stem Cell Reports. 2017 Jul 11;9(1):304-314. doi: 10.1016/j.stemcr.2017.05.006. Epub 2017 Jun 8.


PTEN, Longevity and Age-Related Diseases.

Tait IS, Li Y, Lu J.

Biomedicines. 2013 Dec 13;1(1):17-48. doi: 10.3390/biomedicines1010017. Review.


Wnt Signaling in Normal and Malignant Stem Cells.

Bhavanasi D, Klein PS.

Curr Stem Cell Rep. 2016 Dec;2(4):379-387. doi: 10.1007/s40778-016-0068-y. Epub 2016 Oct 13.


Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.

Nguyen-McCarty M, Klein PS.

PLoS One. 2017 May 9;12(5):e0177054. doi: 10.1371/journal.pone.0177054. eCollection 2017.


An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.

Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD.

Cell Stem Cell. 2017 Jul 6;21(1):91-106.e6. doi: 10.1016/j.stem.2017.03.023. Epub 2017 Apr 27.


The evolution of lifespan and age-dependent cancer risk.

Rozhok AI, DeGregori J.

Trends Cancer. 2016 Oct;2(10):552-560. doi: 10.1016/j.trecan.2016.09.004.


Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia.

Ghosh J, Kapur R.

Exp Hematol. 2017 Jun;50:13-21. doi: 10.1016/j.exphem.2017.02.004. Epub 2017 Mar 22. Review.


Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.

Kalaitzidis D, Lee D, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM, Scadden DT.

J Clin Invest. 2017 Apr 3;127(4):1405-1413. doi: 10.1172/JCI89452. Epub 2017 Mar 20.


Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.

Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR.

Cell Rep. 2017 Feb 28;18(9):2088-2095. doi: 10.1016/j.celrep.2017.02.022.


Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis.

Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HR.

J Immunol. 2017 Apr 1;198(7):2854-2864. doi: 10.4049/jimmunol.1602006. Epub 2017 Feb 24.


Biology and relevance of human acute myeloid leukemia stem cells.

Thomas D, Majeti R.

Blood. 2017 Mar 23;129(12):1577-1585. doi: 10.1182/blood-2016-10-696054. Epub 2017 Feb 3. Review.


Targeting acute myeloid leukemia stem cell signaling by natural products.

Siveen KS, Uddin S, Mohammad RM.

Mol Cancer. 2017 Jan 30;16(1):13. doi: 10.1186/s12943-016-0571-x. Review.


Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells.

Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo V, Ishizawa J, Hail N Jr, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M.

Cancer Res. 2017 Mar 15;77(6):1453-1464. doi: 10.1158/0008-5472.CAN-16-1645. Epub 2017 Jan 20.


Pten is necessary for the quiescence and maintenance of adult muscle stem cells.

Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff TL, Gavin TP, Kuang S.

Nat Commun. 2017 Jan 17;8:14328. doi: 10.1038/ncomms14328.


Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells.

Yuan ZX, Mo J, Zhao G, Shu G, Fu HL, Zhao W.

Front Pharmacol. 2016 Nov 10;7:423. eCollection 2016. Review.


Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives.

Ong PS, Wang LZ, Dai X, Tseng SH, Loo SJ, Sethi G.

Front Pharmacol. 2016 Oct 25;7:395. eCollection 2016. Review.

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