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Items: 1 to 20 of 21


The GDNF Family: A Role in Cancer?

Fielder GC, Yang TW, Razdan M, Li Y, Lu J, Perry JK, Lobie PE, Liu DX.

Neoplasia. 2018 Jan;20(1):99-117. doi: 10.1016/j.neo.2017.10.010. Epub 2017 Dec 12. Review.


Growth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice.

Ren YA, Liu Z, Mullany LK, Fan CM, Richards JS.

Biol Reprod. 2016 Feb;94(2):44. doi: 10.1095/biolreprod.115.133058. Epub 2016 Jan 6.


Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels.

Sacilotto N, Castillo J, Riffo-Campos ÁL, Flores JM, Hibbitt O, Wade-Martins R, López C, Rodrigo MI, Franco L, López-Rodas G.

PLoS One. 2015 Jul 10;10(7):e0132477. doi: 10.1371/journal.pone.0132477. eCollection 2015.


Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1.

Rosti K, Goldman A, Kajander T.

BMC Biochem. 2015 Feb 28;16:8. doi: 10.1186/s12858-015-0037-6.


WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.

Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA.

Development. 2015 Apr 1;142(7):1254-66. doi: 10.1242/dev.119735.


Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection.

Cabrera JR, Viejo-Borbolla A, Martinez-Martín N, Blanco S, Wandosell F, Alcamí A.

PLoS Pathog. 2015 Jan 22;11(1):e1004571. doi: 10.1371/journal.ppat.1004571. eCollection 2015 Jan.


Gas1 is a receptor for sonic hedgehog to repel enteric axons.

Jin S, Martinelli DC, Zheng X, Tessier-Lavigne M, Fan CM.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E73-80. doi: 10.1073/pnas.1418629112. Epub 2014 Dec 22.


Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.

Zhang L, He S, Guo S, Xie W, Xin R, Yu H, Yang F, Qiu J, Zhang D, Zhou S, Zhang K.

J Diabetes Complications. 2014 May-Jun;28(3):259-64. doi: 10.1016/j.jdiacomp.2014.01.002. Epub 2014 Jan 11.


Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling.

Biau S, Jin S, Fan CM.

Biol Open. 2013 Feb 15;2(2):144-55. doi: 10.1242/bio.20123186. Epub 2012 Nov 20.


Evidence for retrogene origins of the prion gene family.

Ehsani S, Tao R, Pocanschi CL, Ren H, Harrison PM, Schmitt-Ulms G.

PLoS One. 2011;6(10):e26800. doi: 10.1371/journal.pone.0026800. Epub 2011 Oct 27.


Gas1 interferes with AβPP trafficking by facilitating the accumulation of immature AβPP in endoplasmic reticulum-associated raft subdomains.

Chapuis J, Vingtdeux V, Capiralla H, Davies P, Marambaud P.

J Alzheimers Dis. 2012;28(1):127-35. doi: 10.3233/JAD-2011-110434.


Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH.

Pineda-Alvarez DE, Roessler E, Hu P, Srivastava K, Solomon BD, Siple CE, Fan CM, Muenke M.

Hum Genet. 2012 Feb;131(2):301-10. doi: 10.1007/s00439-011-1078-6. Epub 2011 Aug 13.


Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.

Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP.

Dev Cell. 2011 Jun 14;20(6):775-87. doi: 10.1016/j.devcel.2011.04.018.


Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein.

Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P.

Hum Mol Genet. 2011 May 15;20(10):2026-36. doi: 10.1093/hmg/ddr085. Epub 2011 Feb 28.


A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene.

Gobeil S, Zhu X, Doillon CJ, Green MR.

Genes Dev. 2008 Nov 1;22(21):2932-40. doi: 10.1101/gad.1714608.


The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding.

Parkash V, Leppänen VM, Virtanen H, Jurvansuu JM, Bespalov MM, Sidorova YA, Runeberg-Roos P, Saarma M, Goldman A.

J Biol Chem. 2008 Dec 12;283(50):35164-72. doi: 10.1074/jbc.M802543200. Epub 2008 Oct 8.


The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution.

Matus DQ, Magie CR, Pang K, Martindale MQ, Thomsen GH.

Dev Biol. 2008 Jan 15;313(2):501-18. Epub 2007 Sep 26.


Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog.

Seppala M, Depew MJ, Martinelli DC, Fan CM, Sharpe PT, Cobourne MT.

J Clin Invest. 2007 Jun;117(6):1575-84. Epub 2007 May 24.


Gas1 extends the range of Hedgehog action by facilitating its signaling.

Martinelli DC, Fan CM.

Genes Dev. 2007 May 15;21(10):1231-43.


Leishmania major abrogates gamma interferon-induced gene expression in human macrophages from a global perspective.

Dogra N, Warburton C, McMaster WR.

Infect Immun. 2007 Jul;75(7):3506-15. Epub 2007 Apr 30.

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