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Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma.

Gao W, Li W, Xiao T, Liu XS, Kaelin WG Jr.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1027-1032. doi: 10.1073/pnas.1619726114. Epub 2017 Jan 12.


Protein Kinase Cδ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity.

Zhang D, Pan J, Xiang X, Liu Y, Dong G, Livingston MJ, Chen JK, Yin XM, Dong Z.

J Am Soc Nephrol. 2017 Apr;28(4):1131-1144. doi: 10.1681/ASN.2016030337. Epub 2016 Oct 31.


Complex role of HIF in cancer: the known, the unknown, and the unexpected.

Tiburcio PD, Choi H, Huang LE.

Hypoxia (Auckl). 2014 Jun 18;2:59-70. eCollection 2014. Review.


Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection.

Sung SJ, Li L, Huang L, Lawler J, Ye H, Rosin DL, Vincent IS, Le TH, Yu J, Görldt N, Schrader J, Okusa MD.

J Am Soc Nephrol. 2017 Mar;28(3):888-902. doi: 10.1681/ASN.2016020229. Epub 2016 Sep 14.


Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis.

Schönenberger D, Rajski M, Harlander S, Frew IJ.

Oncotarget. 2016 Sep 20;7(38):60971-60985. doi: 10.18632/oncotarget.11275.


VHLdb: A database of von Hippel-Lindau protein interactors and mutations.

Tabaro F, Minervini G, Sundus F, Quaglia F, Leonardi E, Piovesan D, Tosatto SC.

Sci Rep. 2016 Aug 11;6:31128. doi: 10.1038/srep31128.


Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.

Johansson E, Rönö B, Johansson M, Lindgren D, Möller C, Axelson H, Smith EM.

Sci Rep. 2016 Aug 5;6:30739. doi: 10.1038/srep30739.


Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma.

Noonan HR, Metelo AM, Kamei CN, Peterson RT, Drummond IA, Iliopoulos O.

Dis Model Mech. 2016 Aug 1;9(8):873-84. doi: 10.1242/dmm.024380.


Novel drugs that target the metabolic reprogramming in renal cell cancer.

van der Mijn JC, Panka DJ, Geissler AK, Verheul HM, Mier JW.

Cancer Metab. 2016 Jul 13;4:14. doi: 10.1186/s40170-016-0154-8. eCollection 2016. Review.


CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma.

Schokrpur S, Hu J, Moughon DL, Liu P, Lin LC, Hermann K, Mangul S, Guan W, Pellegrini M, Xu H, Wu L.

Sci Rep. 2016 Jun 30;6:29032. doi: 10.1038/srep29032.


Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M.

Zhu F, Liu W, Li T, Wan J, Tian J, Zhou Z, Li H, Liu Y, Hou FF, Nie J.

Oncotarget. 2016 May 3;7(18):25604-19. doi: 10.18632/oncotarget.8238.


Proximal tubule-specific glutamine synthetase deletion alters basal and acidosis-stimulated ammonia metabolism.

Lee HW, Osis G, Handlogten ME, Lamers WH, Chaudhry FA, Verlander JW, Weiner ID.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1229-42. doi: 10.1152/ajprenal.00547.2015. Epub 2016 Mar 23.


BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21.

Lee H, Dai F, Zhuang L, Xiao ZD, Kim J, Zhang Y, Ma L, You MJ, Wang Z, Gan B.

Oncotarget. 2016 Apr 12;7(15):19134-46. doi: 10.18632/oncotarget.8102.


Autophagy Limits Endotoxemic Acute Kidney Injury and Alters Renal Tubular Epithelial Cell Cytokine Expression.

Leventhal JS, Ni J, Osmond M, Lee K, Gusella GL, Salem F, Ross MJ.

PLoS One. 2016 Mar 18;11(3):e0150001. doi: 10.1371/journal.pone.0150001. eCollection 2016.


MicroRNA-489 Induction by Hypoxia-Inducible Factor-1 Protects against Ischemic Kidney Injury.

Wei Q, Liu Y, Liu P, Hao J, Liang M, Mi QS, Chen JK, Dong Z.

J Am Soc Nephrol. 2016 Sep;27(9):2784-96. doi: 10.1681/ASN.2015080870. Epub 2016 Mar 14.


Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin.

Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O'Connor PM, Haase VH.

J Clin Invest. 2016 Apr 1;126(4):1425-37. doi: 10.1172/JCI74997. Epub 2016 Feb 29.


Autophagy is activated to protect against endotoxic acute kidney injury.

Mei S, Livingston M, Hao J, Li L, Mei C, Dong Z.

Sci Rep. 2016 Feb 26;6:22171. doi: 10.1038/srep22171.


Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.

Espana-Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson DA, Adams DJ, Matakidou A.

PLoS One. 2016 Feb 11;11(2):e0148055. doi: 10.1371/journal.pone.0148055. eCollection 2016.


Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells.

Venkatareddy M, Verma R, Kalinowski A, Patel SR, Shisheva A, Garg P.

J Am Soc Nephrol. 2016 Sep;27(9):2702-19. doi: 10.1681/ASN.2015050555. Epub 2016 Jan 29.


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