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Items: 1 to 20 of 56

1.

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel.

Li M, Zhang WK, Benvin NM, Zhou X, Su D, Li H, Wang S, Michailidis IE, Tong L, Li X, Yang J.

Nat Struct Mol Biol. 2017 Mar;24(3):205-213. doi: 10.1038/nsmb.3362. Epub 2017 Jan 23.

PMID:
28112729
2.

Inhibition of Transient Receptor Potential Channel Mucolipin-1 (TRPML1) by Lysosomal Adenosine Involved in Severe Combined Immunodeficiency Diseases.

Zhong XZ, Zou Y, Sun X, Dong G, Cao Q, Pandey A, Rainey JK, Zhu X, Dong XP.

J Biol Chem. 2017 Feb 24;292(8):3445-3455. doi: 10.1074/jbc.M116.743963. Epub 2017 Jan 13.

PMID:
28087698
3.

Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View.

Staudt C, Puissant E, Boonen M.

Int J Mol Sci. 2016 Dec 28;18(1). pii: E47. doi: 10.3390/ijms18010047. Review.

4.

Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation.

Zheng W, Yang J, Beauchamp E, Cai R, Hussein S, Hofmann L, Li Q, Flockerzi V, Berthiaume LG, Tang J, Chen XZ.

J Biol Chem. 2016 Dec 2;291(49):25678-25691. Epub 2016 Oct 17.

PMID:
27754867
5.

Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx.

Kilpatrick BS, Yates E, Grimm C, Schapira AH, Patel S.

J Cell Sci. 2016 Oct 15;129(20):3859-3867. Epub 2016 Aug 30.

6.

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.

Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H.

Nat Commun. 2016 Jun 30;7:12109. doi: 10.1038/ncomms12109.

7.

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.

Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL.

PLoS One. 2016 Jun 28;11(6):e0158269. doi: 10.1371/journal.pone.0158269. eCollection 2016 Jun 28.

8.

Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.

Schwartz V, Friedrich K, Polleichtner G, Gründer S.

Sci Rep. 2015 Dec 15;5:18242. doi: 10.1038/srep18242.

9.

Novel Role of TRPML2 in the Regulation of the Innate Immune Response.

Sun L, Hua Y, Vergarajauregui S, Diab HI, Puertollano R.

J Immunol. 2015 Nov 15;195(10):4922-32. doi: 10.4049/jimmunol.1500163. Epub 2015 Oct 2.

10.

Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV.

Grishchuk Y, Peña KA, Coblentz J, King VE, Humphrey DM, Wang SL, Kiselyov KI, Slaugenhaupt SA.

Dis Model Mech. 2015 Dec;8(12):1591-601. doi: 10.1242/dmm.021154. Epub 2015 Sep 17.

11.

The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.

Cuajungco MP, Silva J, Habibi A, Valadez JA.

Pflugers Arch. 2016 Feb;468(2):177-92. doi: 10.1007/s00424-015-1732-2. Epub 2015 Sep 4. Review.

12.

The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase.

Onyenwoke RU, Sexton JZ, Yan F, Díaz MC, Forsberg LJ, Major MB, Brenman JE.

Biochem J. 2015 Sep 15;470(3):331-42. doi: 10.1042/BJ20150219. Epub 2015 Jul 20.

13.

Lysosomal physiology.

Xu H, Ren D.

Annu Rev Physiol. 2015;77:57-80. doi: 10.1146/annurev-physiol-021014-071649. Review.

14.

The role of TRPMLs in endolysosomal trafficking and function.

Venkatachalam K, Wong CO, Zhu MX.

Cell Calcium. 2015 Jul;58(1):48-56. doi: 10.1016/j.ceca.2014.10.008. Epub 2014 Oct 28. Review.

15.

Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1.

Feng X, Xiong J, Lu Y, Xia X, Zhu MX.

Cell Calcium. 2014 Dec;56(6):446-56. doi: 10.1016/j.ceca.2014.09.004. Epub 2014 Sep 19.

16.

Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.

Cuajungco MP, Basilio LC, Silva J, Hart T, Tringali J, Chen CC, Biel M, Grimm C.

Traffic. 2014 Nov;15(11):1247-65. doi: 10.1111/tra.12205. Epub 2014 Sep 2.

17.

Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis.

Martina JA, Diab HI, Li H, Puertollano R.

Cell Mol Life Sci. 2014 Jul;71(13):2483-97. doi: 10.1007/s00018-014-1565-8. Epub 2014 Jan 30. Review.

18.

The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.

Martina JA, Diab HI, Lishu L, Jeong-A L, Patange S, Raben N, Puertollano R.

Sci Signal. 2014 Jan 21;7(309):ra9. doi: 10.1126/scisignal.2004754.

19.

Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation.

Liu B, Fang M, Hu Y, Huang B, Li N, Chang C, Huang R, Xu X, Yang Z, Chen Z, Liu W.

Autophagy. 2014 Mar;10(3):416-30. doi: 10.4161/auto.27286. Epub 2013 Dec 23.

20.

Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo.

Mattila PE, Raghavan V, Rbaibi Y, Baty CJ, Weisz OA.

Am J Physiol Cell Physiol. 2014 Mar 1;306(5):C441-9. doi: 10.1152/ajpcell.00236.2013. Epub 2013 Oct 23.

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