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Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid.

Wei D, Huang X, Qiao Y, Rao J, Wang L, Liao F, Zhan CG.

ACS Catal. 2017 Jul 7;7(7):4623-4636. doi: 10.1021/acscatal.7b00901. Epub 2017 Jun 15.


A Trivalent Enzymatic System for Uricolytic Therapy of HPRT Deficiency and Lesch-Nyhan Disease.

Ronda L, Marchetti M, Piano R, Liuzzi A, Corsini R, Percudani R, Bettati S.

Pharm Res. 2017 Jul;34(7):1477-1490. doi: 10.1007/s11095-017-2167-6. Epub 2017 May 15.


Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions.

Blais EM, Rawls KD, Dougherty BV, Li ZI, Kolling GL, Ye P, Wallqvist A, Papin JA.

Nat Commun. 2017 Feb 8;8:14250. doi: 10.1038/ncomms14250.


A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.

Nyborg AC, Ward C, Zacco A, Chacko B, Grinberg L, Geoghegan JC, Bean R, Wendeler M, Bartnik F, O'Connor E, Gruia F, Iyer V, Feng H, Roy V, Berge M, Miner JN, Wilson DM, Zhou D, Nicholson S, Wilker C, Wu CY, Wilson S, Jermutus L, Wu H, Owen DA, Osbourn J, Coats S, Baca M.

PLoS One. 2016 Dec 21;11(12):e0167935. doi: 10.1371/journal.pone.0167935. eCollection 2016.


Catalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in Hominoids.

Marchetti M, Liuzzi A, Fermi B, Corsini R, Folli C, Speranzini V, Gandolfi F, Bettati S, Ronda L, Cendron L, Berni R, Zanotti G, Percudani R.

Sci Rep. 2016 Dec 6;6:38302. doi: 10.1038/srep38302.


Critical appraisal of the role of pegloticase in the management of gout.

Ea HK, Richette P.

Open Access Rheumatol. 2012 Jun 26;4:63-70. eCollection 2012. Review.


Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed Mutagenesis.

Xie G, Yang W, Chen J, Li M, Jiang N, Zhao B, Chen S, Wang M, Chen J.

Int J Mol Sci. 2016 May 20;17(5). pii: E764. doi: 10.3390/ijms17050764.


The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme.

Doniselli N, Monzeglio E, Dal Palù A, Merli A, Percudani R.

Sci Rep. 2015 Sep 8;5:13798. doi: 10.1038/srep13798.


Cracking the nodule worm code advances knowledge of parasite biology and biotechnology to tackle major diseases of livestock.

Tyagi R, Joachim A, Ruttkowski B, Rosa BA, Martin JC, Hallsworth-Pepin K, Zhang X, Ozersky P, Wilson RK, Ranganathan S, Sternberg PW, Gasser RB, Mitreva M.

Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):980-91. doi: 10.1016/j.biotechadv.2015.05.004. Epub 2015 May 27. Review.


Genetic characterization of caffeine degradation by bacteria and its potential applications.

Summers RM, Mohanty SK, Gopishetty S, Subramanian M.

Microb Biotechnol. 2015 May;8(3):369-78. doi: 10.1111/1751-7915.12262. Epub 2015 Feb 12. Review.


Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.

Bui S, von Stetten D, Jambrina PG, Prangé T, Colloc'h N, de Sanctis D, Royant A, Rosta E, Steiner RA.

Angew Chem Int Ed Engl. 2014 Dec 8;53(50):13710-4. doi: 10.1002/anie.201405485. Epub 2014 Oct 14.


Assessing the metabolic impact of nitrogen availability using a compartmentalized maize leaf genome-scale model.

Simons M, Saha R, Amiour N, Kumar A, Guillard L, Clément G, Miquel M, Li Z, Mouille G, Lea PJ, Hirel B, Maranas CD.

Plant Physiol. 2014 Nov;166(3):1659-74. doi: 10.1104/pp.114.245787. Epub 2014 Sep 23.


Geometric consequences of electron delocalization for adenine tautomers in aqueous solution.

Raczyńska ED, Makowski M.

J Mol Model. 2014 Jun;20(6):2234. doi: 10.1007/s00894-014-2234-4. Epub 2014 May 15.


Evolutionary history and metabolic insights of ancient mammalian uricases.

Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3763-8. doi: 10.1073/pnas.1320393111. Epub 2014 Feb 18.


The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus.

Schwarz EM, Korhonen PK, Campbell BE, Young ND, Jex AR, Jabbar A, Hall RS, Mondal A, Howe AC, Pell J, Hofmann A, Boag PR, Zhu XQ, Gregory T, Loukas A, Williams BA, Antoshechkin I, Brown C, Sternberg PW, Gasser RB.

Genome Biol. 2013 Aug 28;14(8):R89. doi: 10.1186/gb-2013-14-8-r89.


Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study.

Seymour CW, Yende S, Scott MJ, Pribis J, Mohney RP, Bell LN, Chen YF, Zuckerbraun BS, Bigbee WL, Yealy DM, Weissfeld L, Kellum JA, Angus DC.

Intensive Care Med. 2013 Aug;39(8):1423-34. doi: 10.1007/s00134-013-2935-7. Epub 2013 May 15.


Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans.

Lee IR, Yang L, Sebetso G, Allen R, Doan TH, Blundell R, Lui EY, Morrow CA, Fraser JA.

PLoS One. 2013 May 7;8(5):e64292. doi: 10.1371/journal.pone.0064292. Print 2013.


Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway.

Lee IR, Lui EY, Chow EW, Arras SD, Morrow CA, Fraser JA.

Genetics. 2013 Jun;194(2):421-33. doi: 10.1534/genetics.113.150326. Epub 2013 Apr 5.


Uric acid spherulites in the reflector layer of firefly light organ.

Goh KS, Sheu HS, Hua TE, Kang MH, Li CW.

PLoS One. 2013;8(2):e56406. doi: 10.1371/journal.pone.0056406. Epub 2013 Feb 18.

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